Ceramide induces cell death in the human prostatic carcinoma cell lines PC3 and DU145 but does not seem to be involved in Fas-mediated apoptosis. (Q40877017)

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English	Ceramide induces cell death in the human prostatic carcinoma cell lines PC3 and DU145 but does not seem to be involved in Fas-mediated apoptosis.	scientific article

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7 November 2019

Ceramide induces cell death in the human prostatic carcinoma cell lines PC3 and DU145 but does not seem to be involved in Fas-mediated apoptosis (English)

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Europe PubMed Central

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7 November 2019

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7 November 2019

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O W Rokhlin

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7 November 2019

M B Cohen

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1 May 2000

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7 November 2019

Laboratory Investigation

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7 November 2019

80

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7 November 2019

671-676

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7 November 2019

https://scigraph.springernature.com/pub.10.1038/labinvest.3780070

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Death receptors: signaling and modulation

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Functions of ceramide in coordinating cellular responses to stress

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Ceramide in apoptosis--does it really matter?

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Role for ceramide in cell cycle arrest.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Killing of T lymphocytes by synthetic ceramide is by a nonapoptotic mechanism and is abrogated following mitogenic activation

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

The Fas death factor

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Requirement of AP-1 for Ceramide-induced Apoptosis in Human Leukemia HL-60 Cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Evidence against an early signalling role for ceramide in Fas-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

On the complexities of ceramide changes in cells undergoing apoptosis: lack of evidence for a second messenger function in apoptotic induction

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Fas-induced apoptosis of T cells occurs independently of ceramide generation

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

FLICE Induced Apoptosis in a Cell-free System

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

21 January 2018

Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

7 January 2021

based on heuristic

inferred from DOI database lookup

Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

7 January 2021

based on heuristic

inferred from DOI database lookup

Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

7 January 2021

based on heuristic

inferred from DOI database lookup

Programmed cell death induced by ceramide

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

7 January 2021

based on heuristic

inferred from DOI database lookup

TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

7 January 2021

based on heuristic

inferred from DOI database lookup

CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP32 inhibition

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of programmed cell death in human retinoblastoma Y79 cells by C2-ceramide

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

7 January 2021

based on heuristic

inferred from DOI database lookup

Ceramide activates the stress-activated protein kinases

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780070

7 January 2021

based on heuristic

inferred from DOI database lookup

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