The immunologic insult in type 1 diabetes (Q40878852)

24 September 2017

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title

The immunologic insult in type 1 diabetes (English)

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24 September 2017

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M C Honeyman

1

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PubMed ID

8438209

24 September 2017

L C Harrison

series ordinal

2

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24 September 2017

1 January 1993

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Seminars in Immunopathology

24 September 2017

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24 September 2017

14

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24 September 2017

3

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24 September 2017

253-274

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https://scigraph.springernature.com/pub.10.1007/bf00195977

24 September 2017

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cites work

Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies

1 reference

12 December 2020

T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice

1 reference

12 December 2020

Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation

1 reference

12 December 2020

T cell receptor V gene usage of islet beta cell-reactive T cells is not restricted in non-obese diabetic mice

1 reference

12 December 2020

Reduced risk of IDDM among breast-fed children. The Colorado IDDM Registry

1 reference

12 December 2020

The Spontaneously Diabetic Wistar Rat: Metabolic and Morphologic Studies

1 reference

12 December 2020

Characterization of pancreatic islet cell infiltrates in NOD mice: effect of cell transfer and transgene expression

1 reference

12 December 2020

Association between HLA-DR2 and Production of Tumour Necrosis Factor alpha and Interleukin 1 by Mononuclear Cells Activated by Lipopolysaccharide

1 reference

12 December 2020

Abnormalities of CD4+ T lymphocyte proliferative responses from patients with recently diagnosed insulin-dependent diabetes mellitus

1 reference

12 December 2020

Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus

1 reference

12 December 2020

Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes

1 reference

12 December 2020

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

1 reference

12 December 2020

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

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12 December 2020

Human TH1 and TH2 subsets: doubt no more

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12 December 2020

Abnormalities within CD4 and CD8 T lymphocyte subsets in type 1 (insulin-dependent) diabetes

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12 December 2020

Interferon-gamma enhances the expression of the major histocompatibility class I antigens on mouse pancreatic beta cells

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12 December 2020

Pathologic anatomy of the pancreas in juvenile diabetes mellitus

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12 December 2020

Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats

1 reference

12 December 2020

Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain

1 reference

12 December 2020

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

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12 December 2020

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice

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12 December 2020

Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin-2 in islet beta cells

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12 December 2020

Islet-infiltrating T cell clones from non-obese diabetic mice that promote or prevent accelerated onset diabetes

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12 December 2020

Evidence for the effects of a superantigen in rheumatoid arthritis

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12 December 2020

Linkage of Faulty Major Histocompatibility Complex Class I to Autoimmune Diabetes

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12 December 2020

Lack of association of T cell receptor beta-chain constant region polymorphism with insulin-dependent diabetes mellitus in Finland

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12 December 2020

Mechanisms of pancreatic beta-cell destruction in type I diabetes

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12 December 2020

Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice. Evidence for thymic T cell anergy that correlates with the onset of insulitis

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12 December 2020

Molecular pathology of type 1 diabetes.

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12 December 2020

Interleukin-1 induced impairment in pancreatic islet oxidative metabolism of glucose is potentiated by tumor necrosis factor

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12 December 2020

Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection

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12 December 2020

Effects of radical scavengers on the development of experimental diabetes

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12 December 2020

Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages

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12 December 2020

CD8+ T cell homing to the pancreas in the nonobese diabetic mouse is CD4+ T cell-dependent

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12 December 2020

Interleukin-1 induces rapid and transient expression of the c-fos proto-oncogene in isolated pancreatic islets and in purified beta-cells

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12 December 2020

Selective activation of T cells in newly diagnosed insulin-dependent diabetic patients: evidence for heterogeneity of T cell receptor usage

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12 December 2020

T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells

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12 December 2020

Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomes

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12 December 2020

Characterization of pancreatic T lymphocytes associated with beta cell destruction in the non-obese diabetic (NOD) mouse

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12 December 2020

Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus

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12 December 2020

Prevention of cyclophosphamide-induced diabetes by anti-V beta 8 T-lymphocyte-receptor monoclonal antibody therapy in NOD/Wehi mice

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12 December 2020

Macrophage cytotoxicity towards isolated rat islet cells: neither lysis nor its protection by nicotinamide are Beta-cell specific

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12 December 2020

Do CD4-positive cytotoxic T cells damage islet beta cells in type 1 diabetes?

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12 December 2020

T-cell receptor genes and insulin-dependent diabetes mellitus (IDDM): no evidence for linkage from affected sib pairs

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12 December 2020

Breeding of a non-obese, diabetic strain of mice

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12 December 2020

Mechanisms of streptozotocin- and alloxan-induced damage in rat B cells

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12 December 2020

The effect of HLA and insulin-dependent diabetes mellitus on the secretion levels of tumour necrosis factors alpha and beta and gamma interferon

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12 December 2020

Studies of concanavalin A in nonobese diabetic mice. II. Lymphocyte tracking and phenotype responses

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12 December 2020

Identification and cloning of a granule autoantigen (carboxypeptidase-H) associated with type I diabetes

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12 December 2020

Initial role of macrophage in the development of anti-beta-cell cellular autoimmunity in multiple low-dose streptozotocin-induced diabetes in mice

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12 December 2020

Dietary prevention of diabetes in the non-obese diabetic mouse

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12 December 2020

An explanation for the protective effect of the MHC class II I–E molecule in murine diabetes

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12 December 2020

Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide

1 reference

12 December 2020

T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes

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12 December 2020

Evidence for initial involvement of macrophage in development of insulitis in NOD mice

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12 December 2020

The staphylococcal enterotoxins and their relatives.

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12 December 2020

Interferon-gamma regulates an antigen specific for endothelial cells involved in lymphocyte traffic

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12 December 2020

Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes.

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12 December 2020

Aberrant expression of class II major histocompatibility complex molecules by B cells and hyperexpression of class I major histocompatibility complex molecules by insulin containing islets in type 1 (insulin-dependent) diabetes mellitus

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12 December 2020

The order of islet microvascular cellular perfusion is B----A----D in the perfused rat pancreas

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12 December 2020

IFN-gamma induces islet cell MHC antigens and enhances autoimmune, streptozotocin-induced diabetes in the mouse

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12 December 2020

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice

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12 December 2020

Administration of silica prevents diabetes in BB-rats

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12 December 2020

Thymus transplantation and disease prevention in the diabetes-prone Bio-Breeding rat.

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12 December 2020

Studies on autoimmunity for initiation of beta-cell destruction. V. Decrease of macrophage-dependent T lymphocytes and natural killer cytotoxicity in silica-treated BB rats.

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12 December 2020

Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat.

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12 December 2020

Islet-reactive T cells are a marker of preclinical insulin-dependent diabetes

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12 December 2020

Perspectives on the role of viruses in insulin-dependent diabetes

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12 December 2020

Heterogeneity in lymphokine profiles of CD4+ and CD8+ T cells and clones activated in vivo and in vitro

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12 December 2020

Glucagon, catecholamine and pancreatic polypeptide secretion in type I diabetic recipients of pancreas allografts.

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12 December 2020

Cytokine-mediated beta-cell destruction--the molecular effector mechanism causing IDDM?

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12 December 2020

Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite.

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12 December 2020

Evidence for IL-6 production by and effects on the pancreatic beta-cell

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12 December 2020

Reovirus infection enhances expression of class I MHC proteins on human beta-cell and rat RINm5F cell

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12 December 2020

Coffee consumption as trigger for insulin dependent diabetes mellitus in childhood

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12 December 2020

Interaction of immunoglobulin allotypes (Gm and Km), HLA, and sex in insulin-dependent (type 1) diabetes

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12 December 2020

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases

1 reference

12 December 2020

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1 reference

12 December 2020

A tumour necrosis factor beta gene polymorphism in relation to monokine secretion and insulin-dependent diabetes mellitus

1 reference

12 December 2020

Studies on the thymus in nonobese diabetic mouse. I. Changes in the microenvironmental compartments

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12 December 2020

T-Lymphocyte Lines Specific for Glutamic Acid Decarboxylase (GAD) the 64K β-Cell Antigen of IDDM

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12 December 2020

Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.

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12 December 2020

Insulin-secreting beta-cells possess specific receptors for interleukin-1 beta

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12 December 2020

Cytolytic mechanisms of activated macrophages. Tumor necrosis factor and L-arginine-dependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages

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12 December 2020

Prevention of diabetes in NOD mice by injection of autoreactive T-lymphocytes

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12 December 2020

IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans

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12 December 2020

Major histocompatibility complex molecules and the beta cell: inferences from transgenic models.

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12 December 2020

MHC molecules and beta-cell destruction. Immune and nonimmune mechanisms

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12 December 2020

High and Low Diabetes Incidence Nonobese Diabetic (NOD) Mice: Origins and Characterisation

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12 December 2020

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

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12 December 2020

Distinct pathways of CD4 and CD8 cells induce rapid target DNA fragmentation

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12 December 2020

The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice

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12 December 2020

Prevention of lymphocytic thyroiditis and insulitis in diabetes-prone BB rats by the depletion of macrophages

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12 December 2020

Prevention of diabetes in BB/Wor rats treated with monoclonal antibodies to interferon-gamma

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12 December 2020

Prevention of diabetes in non-obese diabetic I-Ak transgenic mice

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12 December 2020

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

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12 December 2020

The bimodal effect of interleukin 1 on rat pancreatic beta-cells--stimulation followed by inhibition--depends upon dose, duration of exposure, and ambient glucose concentration

1 reference

12 December 2020

Interferon-gamma and the sexual dimorphism of autoimmunity

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12 December 2020

Involvement of O2 radicals in 'autoimmune' diabetes

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12 December 2020

Mechanisms of lysis by cytotoxic T lymphocyte clones. Lytic activity and gene expression in cloned antigen-specific CD4+ and CD8+ T lymphocytes

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12 December 2020

Islet cell antigens in insulin-dependent diabetes: Pandora's box revisited

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12 December 2020

Interleukin 1 is potent modulator of insulin secretion from isolated rat islets of Langerhans

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12 December 2020

Self-nonself discrimination by T cells

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12 December 2020

Overexpression of class I major histocompatibility complex accompanies insulitis in the non-obese diabetic mouse and is prevented by anti-interferon-gamma antibody

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12 December 2020

Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma

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12 December 2020

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

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12 December 2020

Role of macrophages in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice

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12 December 2020

8 T cell defined HLA epitopes and T cell receptor polymorphism in insulin dependent diabetes mellitus

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12 December 2020

Defective inducer T-cell function before the onset of insulin-dependent diabetes mellitus

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12 December 2020

Regulation of MHC protein expression in pancreatic beta-cells by interferon-gamma and tumor necrosis factor-alpha

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12 December 2020

Nasopharyngeal carcinoma (NPC).

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12 December 2020

Genetic dissection of T cell receptor V beta gene requirements for spontaneous murine diabetes

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12 December 2020

Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens.

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12 December 2020

Mechanisms of nicotinamide and thymidine protection from alloxan and streptozocin toxicity

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12 December 2020

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

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12 December 2020

T-lymphocyte clone specific for pancreatic islet antigen

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12 December 2020

Prevention of recurrent autoimmune diabetes in BB rats by anti-asialo-GM1 antibody

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12 December 2020

Functional diversity of T lymphocytes due to secretion of different cytokine patterns

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12 December 2020

Multiple low dose streptozotocin induces systemic MHC expression in mice by triggering T cells to release IFN-gamma.

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12 December 2020

In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis

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12 December 2020

Progression from insulitis to beta-cell destruction in NOD mouse requires L3T4+ T-lymphocytes

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12 December 2020

Immunopathology of diabetes in the RT6-depleted diabetes-resistant BB/Wor rat.

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12 December 2020

Preventive effect of a new immunosuppressant FK-506 on insulitis and diabetes in non-obese diabetic mice

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12 December 2020

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion

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12 December 2020

Complement C4 and heat shock protein 70 (HSP70) genotypes and type I diabetes mellitus

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12 December 2020

Quantitative estimation of the pancreatic islet tissue in diabetic subjects

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12 December 2020

A trans-acting major histocompatibility complex-linked gene whose alleles determine gain and loss changes in the antigenic structure of a classical class I molecule

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12 December 2020

The transfer of autoimmune diabetes in NOD mice can be inhibited or accelerated by distinct cell populations present in normal splenocytes taken from young males

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12 December 2020

Relation between breast-feeding and incidence rates of insulin-dependent diabetes mellitus. A hypothesis

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12 December 2020

Evidence for a food additive as a cause of ketosis-prone diabetes

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12 December 2020

Immunogenetic and biological aspects of in vitro lymphocyte allotransformation (MLR) in the mouse

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12 December 2020

Reactivity to human islets and fetal pig proislets by peripheral blood mononuclear cells from subjects with preclinical and clinical insulin-dependent diabetes

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12 December 2020

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma

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12 December 2020

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible

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12 December 2020

Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1

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12 December 2020

Identifiers

DOI

10.1007/BF00195977

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24 September 2017

1 reference

PubMed ID

8438209