Nitric oxide synthase 3 (Q408853)

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mammalian protein found in Homo sapiens
  • nitric oxide synthase 3 transcript variant eNOS-delta21
  • nitric oxide synthase 3 (endothelial cell)
  • nitric oxide synthase 3 transcript variant eNOS-delta20
  • Nitric Oxide Synthase Type III
  • NOS type III
  • eNOS
  • EC-NOS
  • endothelial NOS
  • NOSIII
  • NOS3
  • constitutive NOS
  • cNOS
  • nitric oxide synthase, endothelial
  • nitric oxide synthase 3 transcript variant eNOS-delta20-21
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Language Label Description Also known as
English
Nitric oxide synthase 3
mammalian protein found in Homo sapiens
  • nitric oxide synthase 3 transcript variant eNOS-delta21
  • nitric oxide synthase 3 (endothelial cell)
  • nitric oxide synthase 3 transcript variant eNOS-delta20
  • Nitric Oxide Synthase Type III
  • NOS type III
  • eNOS
  • EC-NOS
  • endothelial NOS
  • NOSIII
  • NOS3
  • constitutive NOS
  • cNOS
  • nitric oxide synthase, endothelial
  • nitric oxide synthase 3 transcript variant eNOS-delta20-21

Statements

molecular function
protein binding
determination method
IPI
15 references
retrieved
9 May 2019
stated in
NOSIP, a novel modulator of endothelial nitric oxide synthase activity
GOA
curator
UniProt
UniProt protein ID
P29474
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
retrieved
9 May 2019
stated in
LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung
GOA
curator
UniProt
UniProt protein ID
P29474
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
retrieved
9 May 2019
stated in
Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase
GOA
curator
UniProt
UniProt protein ID
P29474
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
retrieved
9 May 2019
stated in
Endothelial cell expression of haemoglobin α regulates nitric oxide signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
retrieved
9 May 2019
stated in
Bidirectional cross-regulation between the endothelial nitric oxide synthase and β-catenin signalling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
retrieved
9 May 2019
stated in
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
retrieved
9 May 2019
stated in
NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
retrieved
9 May 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
retrieved
9 May 2019
stated in
Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
retrieved
9 May 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
retrieved
9 May 2019
stated in
Nitric oxide regulates endocytosis by S-nitrosylation of dynamin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
retrieved
9 May 2019
stated in
NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
retrieved
9 May 2019
stated in
beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
retrieved
9 May 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
retrieved
9 May 2019
stated in
Caveolae and caveolin-1 in human term villous trophoblast
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IPI
nitric-oxide synthase activity
determination method
IEA
IDA
IMP
TAS
8 references
retrieved
5 June 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
TAS
retrieved
5 June 2018
stated in
Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IMP
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P29474
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IEA
retrieved
5 June 2018
stated in
Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IDA
retrieved
5 June 2018
stated in
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IDA
retrieved
5 June 2018
stated in
Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IDA
nitric-oxide synthase activity
determination method
IBA
IDA
IEA
IMP
TAS
9 references
retrieved
10 September 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
TAS
retrieved
10 September 2018
stated in
Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IMP
retrieved
10 September 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P29474
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IEA
retrieved
10 September 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IEA
retrieved
10 September 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IEA
retrieved
10 September 2018
stated in
Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IDA
retrieved
10 September 2018
stated in
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IDA
retrieved
10 September 2018
stated in
Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IDA
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29474&geneProductId=UniProtKB:P29474
determination method
IBA
nitric-oxide synthase activity
determination method
IBA
IDA
IEA
IMP
8 references
retrieved
9 May 2019
stated in
Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P29474
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IEA
retrieved
9 May 2019
stated in
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IDA
retrieved
9 May 2019
stated in
Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IDA
retrieved
9 May 2019
stated in
Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29474
determination method
IBA
cell component
biological process

Identifiers

MeSH descriptor ID
D052250
subject named as
Nitric Oxide Synthase Type III
0 references
Microsoft Academic ID
2779698670
0 references
2910364930
0 references
 
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