Chemical features of flavonols affecting their genotoxicity. Potential implications in their use as therapeutical agents. (Q40902202)

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3 November 2019

title

Chemical features of flavonols affecting their genotoxicity. Potential implications in their use as therapeutical agents (English)

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António Sebastião Rodrigues

3 November 2019

author

4

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3 November 2019

José Rueff

6

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3 November 2019

José Rueff

7

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3 November 2019

Jorge F. Gaspar

2

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3 November 2019

author name string

I D Silva

1

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3 November 2019

G G da Costa

3

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3 November 2019

A Laires

5

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3 November 2019

publication date

1 January 2000

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Chemico-biological Interactions

3 November 2019

published in

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3 November 2019

volume

124

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3 November 2019

issue

1

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3 November 2019

page(s)

29-51

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Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study

3 November 2019

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Flavonoids, a class of natural products of high pharmacological potency

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Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids. A structure-activity study

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Involvement of rat cytochrome 1A1 in the biotransformation of kaempferol to quercetin: relevance to the genotoxicity of kaempferol

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Flavonoid Intake and Long-term Risk of Coronary Heart Disease and Cancer in the Seven Countries Study

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Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA

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Interaction between quercetin and superoxide radicals. Reduction of the quercetin mutagenicity

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Flavonoids are scavengers of superoxide anions.

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Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation

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Inhibition of metmyoglobin/H2o2-dependent low density lipoprotein lipid peroxidation by naturally occurring phenolic acids

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Chemopreventive potential of dietary bioflavonoids against 20-methylcholanthrene-induced tumorigenesis.

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Inhibition of 7-ethoxycoumarin O-deethylase activity in rat liver microsomes by naturally occurring flavonoids: structure-activity relationships

7 January 2021

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The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor

7 January 2021

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The quality of genotoxicity testing of drugs. Experiences of a regulatory agency with new and old compounds

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Mutagenicity of plant flavonoids: Structural requirements for mutagenic activity in Salmonella typhimurium

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On the mechanisms of genotoxicity and metabolism of quercetin

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Mechanisms of myricetin mutagenicity in V79 cells: involvement of radicalar species

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DNA strand breaks and chromosomal aberrations induced by H2O2 and 60Co gamma-radiation

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Electrochemistry of flavonoids. Relationships between redox potentials, inhibition of mitochondrial respiration, and production of oxygen radicals by flavonoids

7 January 2021

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7 January 2021

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Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product

7 January 2021

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Role of oxygen radicals in the chromosomal loss and breakage induced by the quinone-forming compounds, hydroquinone and tert-butylhydroquinone

7 January 2021

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The identification of flavonoids as glycosides in human plasma

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Metabolism of galangin by rat cytochromes P450: relevance to the genotoxicity of galangin.

7 January 2021

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0009-2797(99)00139-8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10658900%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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