Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors (Q40902237)

24 September 2017

Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors (English)

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24 September 2017

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Qian Y

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24 September 2017

Marugan JJ

2

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24 September 2017

Fossum RD

3

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24 September 2017

Vogt A

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24 September 2017

Sebti SM

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24 September 2017

Hamilton AD

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24 September 2017

language of work or name

English

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publication date

1 December 1999

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Bioorganic & Medicinal Chemistry

24 September 2017

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24 September 2017

7

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24 September 2017

12

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24 September 2017

3011-3024

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Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

24 September 2017

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Enzymatic modification of proteins with a geranylgeranyl isoprenoid

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

p21ras is modified by a farnesyl isoprenoid

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Signal transduction. How receptors turn Ras on.

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

1 reference

7 January 2021

All ras proteins are polyisoprenylated but only some are palmitoylated

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Farnesyl transferase inhibitors: the successes and surprises of a new class of potential cancer chemotherapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

cDNA cloning and expression of the peptide-binding β subunit of rat p21rasfarnesyltransferase, the counterpart of yeast DPR1/RAM1

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Farnesyltransferase as a target for anticancer drug design

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Ras farnesyltransferase: a new therapeutic target

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Pseudopeptide inhibitors of Ras farnesyl-protein transferase

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Selective reduction of aromatic nitro compounds with stannous chloride in non acidic and non aqueous medium

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Investigations of neurotrophic inhibitors of FK506 binding protein via Monte Carlo simulations

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https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Potent and selective non-cysteine-containing inhibitors of protein farnesyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2899%2900252-7

7 January 2021

10.1016/S0968-0896(99)00252-7

Identifiers

DOI

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24 September 2017

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