DNA gyrase as a drug target (Q40902870)

24 September 2017

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title

DNA gyrase as a drug target (English)

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24 September 2017

1

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24 September 2017

1 March 1997

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24 September 2017

Trends in Microbiology

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24 September 2017

5

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24 September 2017

3

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24 September 2017

102-109

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

24 September 2017

1 reference

7 January 2021

Structure and mechanism of DNA topoisomerases.

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

DNA topoisomerases: essential enzymes and lethal targets

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Topoisomerase poisons: harnessing the dark side of enzyme mechanism.

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

DNA gyrase: structure and function.

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

The mechanisms of DNA topoisomerases

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Crystal structure of an N-terminal fragment of the DNA gyrase B protein.

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

The interaction between coumarin drugs and DNA gyrase

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

The Interaction of Coumarin Antibiotics with Fragments of the DNA Gyrase B Protein†

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

The 24 kDa N-terminal sub-domain of the DNA gyrase B protein binds coumarin drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase.

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

The molecular basis of quinolone action

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Structure-activity and structure-side-effect relationships for the quinolone antibacterials

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Quinolone antibacterials. An update of their pharmacology and therapeutic use.

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Quinolone-resistant mutations of the gyrA gene of Escherichia coli.

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

New topoisomerase essential for chromosome segregation in E. coli.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Detection of mutations in parC in quinolone-resistant clinical isolates of Escherichia coli.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug--DNA binding model

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

DNA cleavage is not required for the binding of quinolone drugs to the DNA gyrase-DNA complex

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

On the mechanism of action of quinolone drugs

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Using SAR and QSAR analysis to model the activity and structure of the quinolone-DNA complex

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

The complex of DNA gyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase.

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Characterization of the interaction between topoisomerase II and DNA by transcriptional footprinting

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Cyclothialidine and its congeners: a new class of DNA gyrase inhibitors

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Mechanism of inhibition of DNA gyrase by cyclothialidine, a novel DNA gyrase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin.

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Characterization of the binding site for cyclothialidine on the B subunit of DNA gyrase

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase.

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

In vitro inhibition of bacterial DNA gyrase by cinodine, a glycocinnamoylspermidine antibiotic

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Clerocidin, a terpenoid antibiotic, inhibits bacterial DNA gyrase

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

The F plasmid CcdB protein induces efficient ATP-dependent DNA cleavage by gyrase.

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes

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https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Control of segregation of chromosomal DNA by sex factor F in Escherichia coli. Mutants of DNA gyrase subunit A suppress letD (ccdB) product growth inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

Structure and mechanism of DNA topoisomerase II

1 reference

https://api.crossref.org/works/10.1016%2FS0966-842X%2896%2910085-8

7 January 2021

10.1016/S0966-842X(96)10085-8

Identifiers

DOI

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24 September 2017

1 reference

PubMed ID

9080608