The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface. (Q40934272)

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scientific article published on August 1999

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English	The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.	scientific article published on August 1999

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scholarly article

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11 December 2019

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface (English)

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11 December 2019

transmembrane protein

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multiple drug resistance

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based on heuristic

inferred from title

1

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11 December 2019

author name string

D M Clarke

2

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11 December 2019

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publication date

1 August 1999

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11 December 2019

Journal of Biological Chemistry

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11 December 2019

274

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11 December 2019

35

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11 December 2019

24759-24765

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11 December 2019

The P-glycoprotein efflux pump: how does it transport drugs?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.35.24759

21 January 2018

Molecular analysis of the multidrug transporter, P-glycoprotein

1 reference

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21 January 2018

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

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21 January 2018

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

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21 January 2018

Diagnosis and reversal of multidrug resistance in paediatric cancers

1 reference

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21 January 2018

Pharmacological considerations in the modulation of multidrug resistance

1 reference

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21 January 2018

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

1 reference

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21 January 2018

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

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21 January 2018

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.35.24759

21 January 2018

Membrane topology of a cysteine-less mutant of human P-glycoprotein

1 reference

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21 January 2018

Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

1 reference

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21 January 2018

Cloning, overexpression, purification, and characterization of the carboxyl-terminal nucleotide binding domain of P-glycoprotein.

1 reference

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21 January 2018

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

1 reference

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21 January 2018

P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

1 reference

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21 January 2018

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

1 reference

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21 January 2018

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

1 reference

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21 January 2018

Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1.

1 reference

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21 January 2018

A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps

1 reference

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21 January 2018

Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site.

1 reference

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21 January 2018

Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

1 reference

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21 January 2018

Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

1 reference

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21 January 2018

P-glycoprotein. Associations between domains and between domains and molecular chaperones

1 reference

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21 January 2018

Functional expression of mouse mdr1 in Escherichia coli

1 reference

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21 January 2018

Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.35.24759

21 January 2018

Mutational analysis of human P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.35.24759

21 January 2018

Characterization of the human multidrug resistance protein containing mutations in the ATP-binding cassette signature region

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.35.24759

21 January 2018

Mutations in the nucleotide-binding sites of P-glycoprotein that affect substrate specificity modulate substrate-induced adenosine triphosphatase activity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.35.24759

21 January 2018

Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.35.24759

21 January 2018

Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.35.24759

21 January 2018

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.35.24759

21 January 2018

Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.35.24759

21 January 2018

Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.35.24759

21 January 2018

Mutational Analysis of the Predicted First Transmembrane Segment of Each Homologous Half of Human P-glycoprotein Suggests That They Are Symmetrically Arranged in the Membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.35.24759

21 January 2018

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.35.24759

21 January 2018

Identifiers

10.1074/JBC.274.35.24759

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10455147%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10455147%20AND%20SRC:MED&resulttype=core&format=json

11 December 2019

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