Loss of the exon encoding the juxtamembrane domain is essential for the oncogenic activation of TPR-MET. (Q40937368)

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10 December 2019

title

Loss of the exon encoding the juxtamembrane domain is essential for the oncogenic activation of TPR-MET (English)

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10 December 2019

5

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10 December 2019

Daniela Gramaglia

2

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10 December 2019

Alberto Bardelli

4

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10 December 2019

author name string

Vigna E

1

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10 December 2019

Longati P

3

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10 December 2019

language of work or name

English

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publication date

1 July 1999

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10 December 2019

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10 December 2019

volume

18

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10 December 2019

issue

29

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10 December 2019

page(s)

4275-4281

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1202791

10 December 2019

exact match

0 references

cites work

Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis.

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Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

21 January 2018

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Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

21 January 2018

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Molecular cloning of a new transforming gene from a chemically transformed human cell line.

21 January 2018

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Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.

21 January 2018

1 reference

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A point mutation in the MET oncogene abrogates metastasis without affecting transformation.

21 January 2018

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Tyrosine kinase receptor indistinguishable from the c-met protein

21 January 2018

1 reference

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Alternatively spliced juxtamembrane domain of a tyrosine kinase receptor is a multifunctional regulatory site. Deletion alters cellular tyrosine phosphorylation pattern and facilitates binding of phosphatidylinositol-3-OH kinase to the hepatocyte gr

21 January 2018

1 reference

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Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors

21 January 2018

1 reference

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The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation

21 January 2018

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Mechanism of met oncogene activation

21 January 2018

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Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors

21 January 2018

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A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

21 January 2018

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Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility

21 January 2018

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Subcellular localization of a protein-tyrosine phosphatase: evidence for association with chromatin

21 January 2018

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Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase

21 January 2018

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Constitutive activation of the RON gene promotes invasive growth but not transformation

21 January 2018

1 reference

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The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions

21 January 2018

1 reference

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TPR-MET oncogenic rearrangement: detection by polymerase chain reaction amplification of the transcript and expression in human tumor cell lines

21 January 2018

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Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors

21 January 2018

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Protein tyrosine phosphatase PTP-S binds to the juxtamembrane region of the hepatocyte growth factor receptor Met.

21 January 2018

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Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells.

21 January 2018

1 reference

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Two Splice Variants of a Tyrosine Phosphatase Differ in Substrate Specificity, DNA Binding, and Subcellular Location

21 January 2018

1 reference

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"Invasive-growth" signaling by the Met/HGF receptor: the hereditary renal carcinoma connection.

21 January 2018

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1202791

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10435641%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 December 2019

0 references

1 reference