Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580. (Q40947866)

25 September 2017

title

Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580. (English)

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25 September 2017

P A Eyers

1

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25 September 2017

P van den IJssel

2

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25 September 2017

R A Quinlan

3

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25 September 2017

M Goedert

4

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25 September 2017

P Cohen

5

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25 September 2017

language of work or name

English

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publication date

1 May 1999

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25 September 2017

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25 September 2017

volume

451

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25 September 2017

issue

2

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25 September 2017

page(s)

191-196

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The search for physiological substrates of MAP and SAP kinases in mammalian cells

25 September 2017

cites work

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

21 January 2018

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Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

21 January 2018

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Raf-1 is activated by the p38 mitogen-activated protein kinase inhibitor, SB203580.

21 January 2018

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The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

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A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

21 January 2018

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Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

21 January 2018

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Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket

21 January 2018

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A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase

21 January 2018

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Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

21 January 2018

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Regulation of System A amino acid transport in L6 rat skeletal muscle cells by insulin, chemical and hyperthermic stress

21 January 2018

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The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2

21 January 2018

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Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

21 January 2018

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A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

21 January 2018

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Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

21 January 2018

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Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors

21 January 2018

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p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient

21 January 2018

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[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

21 January 2018

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Direct Inhibition of Cyclooxygenase-1 and -2 by the Kinase Inhibitors SB 203580 and PD 98059

21 January 2018

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Effect of SB 203580 on the activity of c-Raf in vitro and in vivo

7 January 2021

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10.1016/S0014-5793(99)00552-9

7 January 2021

Identifiers

DOI

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25 September 2017

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