Tk+/- mouse model for detecting in vivo mutation in an endogenous, autosomal gene (Q40971333)

25 September 2017

title

Tk+/- mouse model for detecting in vivo mutation in an endogenous, autosomal gene (English)

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25 September 2017

Dobrovolsky VN

1

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25 September 2017

Casciano DA

series ordinal

2

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25 September 2017

Heflich RH

series ordinal

3

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25 September 2017

language of work or name

English

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publication date

1 January 1999

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25 September 2017

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25 September 2017

volume

423

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25 September 2017

issue

1-2

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25 September 2017

page(s)

125-136

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Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays.

25 September 2017

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Locus specificity in the mutability of L5178Y mouse lymphoma cells: the role of multilocus lesions

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In vitro mammalian mutagenesis as a model for genetic lesions in human cancer

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Genotoxicity of gamma-irradiation in L5178Y mouse lymphoma cells

7 January 2021

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Isolation of an APRT heterozygote from TK6 human lymphoblasts: predominance of multi-locus loss of heterozygosity among spontaneous APRT-mutants

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7 January 2021

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Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue(R) rats treated with 7, 12-dimethylbenz[a]anthracene

7 January 2021

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Relative sensitivity of the endogenous hprt gene and lacI transgene in ENU-treated Big Blue B6C3F1 mice.

7 January 2021

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The mutagenic response at the ouabain resistance locus in T cells of mice exposed to N-ethyl-N-nitrosourea parallels the response at the Hprt locus and correlates with mutation target size

7 January 2021

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A clonal marker induced by mutation in mouse intestinal epithelium

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High-frequency nonrandom mutational event at the adenine phosphoribosyltransferase (aprt) locus of sib-selected CHO variants heterozygous for aprt.

7 January 2021

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A mutational assay system using the thymidine kinase locus in mouse lymphoma cells

7 January 2021

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Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: Possibility for a rapid human cell mutation assay

7 January 2021

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Development of a novel mouse tk+/- embryonic stem cell line for use in mutagenicity studies

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Sequence analysis of tka(-)-1 and tkb(+)-1 alleles in L5178Y tk+/- mouse-lymphoma cells and spontaneous tk-/- mutants

7 January 2021

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Regulation and biological function of thymidine kinase

7 January 2021

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Adenine phosphoribosyltransferase deficiency with renal deposition of 2,8-dihydroxyadenine leading to nephrolithiasis and chronic renal failure

7 January 2021

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A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency

7 January 2021

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HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

7 January 2021

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A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice

7 January 2021

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The utilization of trifluorothymidine (TFT) to select for thymidine kinase-deficient (TK-/-) mutants from L5178Y/TK+/- mouse lymphoma cells.

7 January 2021

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Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations

7 January 2021

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The genetic toxicology of 5-bromodeoxyuridine in mammalian cells

7 January 2021

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The quantitation of TK-/- and HGPRT- mutants of L5178Y/TK+/- mouse lymphoma cells at varying times post-treatment

7 January 2021

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Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferase

7 January 2021

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Use of shuttle vectors to study the molecular processing of defined carcinogen-induced DNA damage: mutagenicity of single O4-ethylthymine adducts in HeLa cells

7 January 2021

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O4-Methyl, -ethyl, or -isopropyl substituents on thymidine in poly(dA-dT) all lead to transitions upon replication

7 January 2021

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Mutational spectrum at the Hprt locus in splenic T cells of B6C3F1 mice exposed to N-ethyl-N-nitrosourea

7 January 2021

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7 January 2021

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Molecular aspects of chemical mutagenesis in L5178Y/tk +/- mouse lymphoma cells

7 January 2021

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International Commission for Protection Against Environmental Mutagens and Carcinogens. Working paper no. 3. Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo

7 January 2021

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Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue rats.

7 January 2021

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The use of L5178Y mouse lymphoma cells to assess the mutagenic, clastogenic and aneugenic properties of chemicals.

7 January 2021

1 reference

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10.1016/S0027-5107(98)00234-6

7 January 2021

Identifiers

DOI

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25 September 2017

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