The FKBP12-rapamycin-binding domain is required for FKBP12-rapamycin-associated protein kinase activity and G1 progression (Q40975191)

25 September 2017

title

The FKBP12-rapamycin-binding domain is required for FKBP12-rapamycin-associated protein kinase activity and G1 progression (English)

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25 September 2017

Vilella-Bach M

1

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25 September 2017

Nuzzi P

series ordinal

2

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25 September 2017

Fang Y

series ordinal

3

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25 September 2017

Chen J

series ordinal

4

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25 September 2017

language of work or name

English

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publication date

1 February 1999

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Journal of Biological Chemistry

25 September 2017

number of pages

7

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based on heuristic

inferred from page(s)

published in

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25 September 2017

volume

274

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25 September 2017

issue

7

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25 September 2017

page(s)

4266-4272

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A signaling pathway to translational control

25 September 2017

cites work

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Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin

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Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

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Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

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Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

21 January 2018

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 January 2018

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Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

21 January 2018

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The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus

21 January 2018

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

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Regulation of eIF-4E BP1 phosphorylation by mTOR.

21 January 2018

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4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

21 January 2018

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21 January 2018

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21 January 2018

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Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

21 January 2018

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RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

21 January 2018

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Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

21 January 2018

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TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

21 January 2018

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Mechanism of TGFβ receptor inhibition by FKBP12

21 January 2018

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A template for the protein kinase family

21 January 2018

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TOR controls translation initiation and early G1 progression in yeast

21 January 2018

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Rapamycin dissociates p70(S6K) activation from DNA synthesis stimulated by bombesin and insulin in Swiss 3T3 cells

21 January 2018

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

21 January 2018

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TOR2 is required for organization of the actin cytoskeleton in yeast

21 January 2018

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The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.

21 January 2018

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Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway

21 January 2018

1 reference

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TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

21 January 2018

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Role of GTP hydrolysis in fission of caveolae directly from plasma membranes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.7.4266

1 reference

25 September 2017

1 reference