Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic osteosarcoma ROS17/2.8 cells and primary rat calvaria cells (Q40995245)

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scientific article published on November 1998

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English	Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic osteosarcoma ROS17/2.8 cells and primary rat calvaria cells	scientific article published on November 1998

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 September 2017

Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic osteosarcoma ROS17/2.8 cells and primary rat calvaria cells (English)

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Europe PubMed Central

PubMed publication ID

25 September 2017

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author name string

Li J

1

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25 September 2017

Tsuji K

2

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25 September 2017

Komori T

3

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25 September 2017

Miyazono K

4

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Europe PubMed Central

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25 September 2017

Wrana JL

5

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Europe PubMed Central

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25 September 2017

Ito Y

6

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25 September 2017

Nifuji A

7

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25 September 2017

Noda M

8

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25 September 2017

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publication date

1 November 1998

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25 September 2017

Journal of Biological Chemistry

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25 September 2017

273

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25 September 2017

47

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25 September 2017

31009-31015

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Europe PubMed Central

PubMed publication ID

25 September 2017

Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor

1 reference

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Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor

1 reference

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Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors

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MADR1, a MAD-related protein that functions in BMP2 signaling pathways

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MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

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Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily

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A human Mad protein acting as a BMP-regulated transcriptional activator

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TGFbeta signaling: receptors, transducers, and Mad proteins.

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TGF-beta signalling through the Smad pathway

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MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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Mad-related genes in the human

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Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4.

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Purification and characterization of two cartilage-inducing factors from bovine demineralized bone

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Increased bone formation in osteocalcin-deficient mice.

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Constitutive transcription of the osteocalcin gene in osteosarcoma cells is reflected by altered protein-DNA interactions at promoter regulatory elements

1 reference

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TGF beta alters growth and differentiation related gene expression in proliferating osteoblasts in vitro, preventing development of the mature bone phenotype.

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PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene

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Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

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Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

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Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene

1 reference

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21 January 2018

A PEBP2 alpha/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element

1 reference

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21 January 2018

An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene

1 reference

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1,25-dihydroxyvitamin D3 inhibits Osteocalcin expression in mouse through an indirect mechanism.

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

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21 January 2018

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

1 reference

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21 January 2018

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

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21 January 2018

Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

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21 January 2018

Characterization of the rat osteocalcin gene: stimulation of promoter activity by 1,25-dihydroxyvitamin D3

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Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein

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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

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21 January 2018

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

1 reference

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21 January 2018

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

1 reference

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21 January 2018

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

1 reference

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Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4

1 reference

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Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

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Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

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The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

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Differentiation dependent expression and distinct subcellular localization of the protooncogene product, PEBP2beta/CBFbeta, in muscle development

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The protooncogene product, PEBP2beta/CBFbeta, is mainly located in the cytoplasm and has an affinity with cytoskeletal structures

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Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts

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Smad6 inhibits signalling by the TGF-beta superfamily

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The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling

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Transcriptional regulation of osteocalcin production by transforming growth factor-beta in rat osteoblast-like cells

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Osteocalcin: Isolation, characterization, and detection

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Functional dissection of the alpha and beta subunits of transcription factor PEBP2 and the redox susceptibility of its DNA binding activity

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Identifiers

10.1074/JBC.273.47.31009

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

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