solute carrier family 6 member 4 (Q410142)

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mammalian protein found in Homo sapiens

• SLC6A4
• Na+/Cl- dependent serotonin transporter
• 5HTT
• solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
• sodium-dependent serotonin transporter
• 5-hydroxytryptamine (serotonin) transporter
• serotonin transporter 1
• 5HT transporter
• solute carrier family 6 (neurotransmitter transporter), member 4
• serotonin transporter
• SERT

edit

Language	Label	Description	Also known as
English	solute carrier family 6 member 4	mammalian protein found in Homo sapiens	SLC6A4 Na+/Cl- dependent serotonin transporter 5HTT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 sodium-dependent serotonin transporter 5-hydroxytryptamine (serotonin) transporter serotonin transporter 1 5HT transporter solute carrier family 6 (neurotransmitter transporter), member 4 serotonin transporter SERT

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P31645

part of

Sodium:neurotransmitter symporter

2 references

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P31645

Transporter Classification Database ID

2.A.22.1.1

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

Sodium:neurotransmitter symporter superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P31645

Sodium:neurotransmitter symporter, serotonin, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

SLC6A4.png
1,920 × 975; 682 KB

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P31645

encoded by

SLC6A4

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P31645

molecular function

cocaine binding

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

nitric-oxide synthase binding

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

protein homodimerization activity

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

myosin binding

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

syntaxin-1 binding

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

metal ion binding

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

neurotransmitter:sodium symporter activity

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

actin filament binding

determination method

ISS

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

monoamine transmembrane transporter activity

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

protein binding

determination method

IPI

4 references

retrieved

9 May 2019

stated in

Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IPI

retrieved

9 May 2019

stated in

Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IPI

retrieved

9 May 2019

stated in

Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IPI

retrieved

9 May 2019

stated in

The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IPI

symporter activity

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

serotonin:sodium symporter activity

determination method

IDA

IEA

IMP

TAS

5 references

retrieved

16 July 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

TAS

retrieved

16 July 2018

stated in

Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IMP

retrieved

16 July 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

16 July 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

16 July 2018

stated in

Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IDA

dopamine:sodium symporter activity

determination method

IBA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IBA

serotonin:sodium symporter activity

determination method

IBA

IDA

IEA

IMP

TAS

6 references

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

TAS

retrieved

1 January 2018

stated in

Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IMP

retrieved

1 January 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

1 January 2018

stated in

Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IBA

serotonin binding

determination method

IBA

1 reference

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IBA

serotonin:sodium symporter activity

determination method

IBA

IDA

IEA

TAS

5 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

TAS

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

9 May 2019

stated in

Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IBA

cell component

integral component of membrane

determination method

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

cytosol

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

endosome

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

membrane

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

integral component of plasma membrane

determination method

IBA

IC

IEA

3 references

retrieved

16 July 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

16 July 2018

stated in

Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IC

retrieved

16 July 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IBA

membrane raft

determination method

IDA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

9 May 2019

stated in

Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

neuron projection

determination method

IBA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IBA

endosome membrane

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

endomembrane system

determination method

IDA

IEA

4 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

9 May 2019

stated in

Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

9 May 2019

stated in

Plasma serotonin levels and the platelet serotonin transporter

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

presynapse

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IEA

plasma membrane

determination method

IDA

IEA

TAS

7 references

retrieved

16 July 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

TAS

retrieved

16 July 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

16 July 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

16 July 2018

stated in

Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

16 July 2018

stated in

Plasma serotonin levels and the platelet serotonin transporter

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

16 July 2018

stated in

Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

16 July 2018

stated in

Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IDA

integral component of postsynaptic membrane

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

integral component of presynaptic membrane

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

serotonergic synapse

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

plasma membrane

determination method

IBA

IDA

IEA

TAS

7 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

TAS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

9 May 2019

stated in

Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

9 May 2019

stated in

Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

9 May 2019

stated in

Plasma serotonin levels and the platelet serotonin transporter

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IBA

integral component of plasma membrane

determination method

IC

IEA

2 references

retrieved

1 January 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

1 January 2018

stated in

Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IC

integral component of plasma membrane

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

focal adhesion

determination method

IEA

ISS

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

synapse

determination method

IEA

ISS

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

biological process

cellular response to organic substance

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

cellular response to retinoic acid

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

response to estradiol

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

cellular response to cGMP

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

response to hypoxia

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

negative regulation of neuron differentiation

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

ejaculation

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

response to nutrient

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

vasoconstriction

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

negative regulation of cerebellar granule cell precursor proliferation

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

memory

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

monoamine transport

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

response to organic substance

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

brain development

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

positive regulation of gene expression

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

positive regulation of cell cycle

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

serotonin transport

determination method

IDA

IEA

2 references

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

1 January 2018

stated in

Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

protein complex oligomerization

determination method

ISS

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

circadian rhythm

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

transmembrane transport

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

social behavior

determination method

ISS

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

serotonin uptake

determination method

IDA

IEA

IMP

7 references

retrieved

16 July 2018

stated in

Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IMP

retrieved

16 July 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

16 July 2018

stated in

Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

16 July 2018

stated in

Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

16 July 2018

stated in

Plasma serotonin levels and the platelet serotonin transporter

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

16 July 2018

stated in

Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

16 July 2018

stated in

Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IDA

neurotransmitter transport

determination method

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

negative regulation of organ growth

determination method

ISS

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

protein homooligomerization

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

response to toxic substance

determination method

IDA

1 reference

retrieved

9 May 2019

stated in

Differential expression of intestinal membrane transporters in cholera patients

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

negative regulation of synaptic transmission, dopaminergic

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

brain morphogenesis

determination method

ISS

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

ISS

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

positive regulation of serotonin secretion

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

neurotransmitter biosynthetic process

determination method

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

TAS

dopamine uptake involved in synaptic transmission

determination method

IBA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645

determination method

IBA

regulation of thalamus size

determination method

IMP

1 reference

retrieved

9 May 2019

stated in

Major depression, 5HTTLPR genotype, suicide and antidepressant influences on thalamic volume

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IMP

serotonin uptake

determination method

IBA

IDA

IEA

IMP

7 references

retrieved

9 May 2019

stated in

Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IMP

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

retrieved

9 May 2019

stated in

Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

9 May 2019

stated in

Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

9 May 2019

stated in

Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

9 May 2019

stated in

Plasma serotonin levels and the platelet serotonin transporter

GOA

curator

UniProt

UniProt protein ID

P31645

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IBA

serotonin transport

determination method

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645

determination method

IEA

physically interacts with

amitriptyline

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

200

language of work or name

English

retrieved

17 August 2016

amoxapine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

201

language of work or name

English

retrieved

17 August 2016

atomoxetine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7118

language of work or name

English

retrieved

17 August 2016

(RS)-citalopram

has use

enzyme inhibitor

2 references

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7547

language of work or name

English

retrieved

17 August 2016

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

4621

language of work or name

English

retrieved

17 August 2016

clomipramine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2398

language of work or name

English

retrieved

17 August 2016

dapoxetine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7901

language of work or name

English

retrieved

17 August 2016

desipramine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2399

language of work or name

English

retrieved

17 August 2016

desvenlafaxine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7158

language of work or name

English

retrieved

17 August 2016

(S)-duloxetine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

202

language of work or name

English

retrieved

17 August 2016

escitalopram

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7177

language of work or name

English

retrieved

17 August 2016

fluoxetine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

203

language of work or name

English

retrieved

17 August 2016

fluvoxamine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7189

language of work or name

English

retrieved

17 August 2016

imipramine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

357

language of work or name

English

retrieved

17 August 2016

levomilnacipran

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7435

language of work or name

English

retrieved

17 August 2016

lofepramine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7551

language of work or name

English

retrieved

17 August 2016

nefazodone

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7247

language of work or name

English

retrieved

17 August 2016

nortriptyline

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2404

language of work or name

English

retrieved

17 August 2016

paroxetine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

4790

language of work or name

English

retrieved

17 August 2016

phenelzine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7266

language of work or name

English

retrieved

17 August 2016

protriptyline

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7285

language of work or name

English

retrieved

17 August 2016

sertraline

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

4798

language of work or name

English

retrieved

17 August 2016

(RS)-sibutramine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2586

language of work or name

English

retrieved

17 August 2016

trimipramine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7317

language of work or name

English

retrieved

17 August 2016

venlafaxine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7321

language of work or name

English

retrieved

17 August 2016

vilazodone

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7427

language of work or name

English

retrieved

17 August 2016

vortioxetine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7351

language of work or name

English

retrieved

17 August 2016

ziprasidone

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

59

language of work or name

English

retrieved

17 August 2016

zotepine

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

103

language of work or name

English

retrieved

17 August 2016

Gene Atlas image

PBB GE SLC6A4 207519 at fs.png
732 × 530; 12 KB

0 references

facilitates flow of

serotonin

0 references

exact match

http://purl.uniprot.org/uniprot/P31645

1 reference

stated in

Identifiers.org

has part(s)

Sodium:neurotransmitter symporter, serotonin, N-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P31645

Commons category

Serotonin transporters

0 references

Identifiers

RefSeq protein ID

NP_001036

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

6532

UniProt protein ID

P31645

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P31645

Ensembl protein ID

ENSP00000261707

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000261707

ENSP00000385822

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000385822

ENSP00000378298

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000378298

ENSP00000463172

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000463172

ENSP00000498537

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000498537

Freebase ID

/m/02fm_d

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

2778897192

0 references

2909985787

0 references

OpenAlex ID

C2778897192

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

5I6X

1 reference

stated in

UniProt

UniProt protein ID

P31645

retrieved

9 August 2016

language of work or name

English

5I73

1 reference

stated in

UniProt

UniProt protein ID

P31645

retrieved

9 August 2016

language of work or name

English

5I75

1 reference

stated in

UniProt

UniProt protein ID

P31645

retrieved

9 August 2016

language of work or name

English

5I6Z

1 reference

stated in

UniProt

UniProt protein ID

P31645

retrieved

9 August 2016

language of work or name

English

5I71

1 reference

stated in

UniProt

UniProt protein ID

P31645

retrieved

9 August 2016

language of work or name

English

5I74

1 reference

stated in

UniProt

UniProt protein ID

P31645

retrieved

9 August 2016

language of work or name

English

Transporter Classification Database ID

2.A.22.1.1

2 references

stated in

Transporter Classification database

retrieved

13 March 2020

stated in

Transporter Classification database

retrieved

29 April 2020

 

Sitelinks

Wikipedia(16 entries)

edit

• arwiki ناقل السيروتونين
• bswiki SLC6A4
• dewiki Serotonintransporter
• enwiki Serotonin transporter
• frwiki Transporteur de la sérotonine
• idwiki Pengangkut serotonin
• jawiki セロトニントランスポーター遺伝子
• lawiki Transportator serotonini
• ptwiki Transportador de serotonina
• ruwiki Транспортёр серотонина
• shwiki Serotoninski transporter
• srwiki Serotoninski transporter
• svwiki Serotonintransportprotein
• trwiki Serotonin taşıyıcısı
• ukwiki Серотоніновий транспортер
• zhwiki 血清素轉運體

Wikibooks(0 entries)

edit

Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q410142&oldid=2071784984"