Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function (Q41020720)

25 September 2017

Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1401063

22 September 2022

3

Hellerström C

1 reference

25 September 2017

D. L. Eizirik

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1401063

22 September 2022

G. S. Korbutt

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1401063

22 September 2022

language of work or name

English

0 references

publication date

1 October 1992

1 reference

PMCID

443168

full work available at URL

25 September 2017

https://europepmc.org/articles/PMC443168

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1401063

https://europepmc.org/articles/PMC443168?pdf=render

22 September 2022

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1401063

Journal of Clinical Investigation

22 September 2022

published in

1 reference

25 September 2017

90

1 reference

25 September 2017

4

1 reference

25 September 2017

1263-1268

1 reference

The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Hyperglycemia-induced B cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

The functional state of the beta cells in the pathogenesis of insulin-dependent diabetes mellitus

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Isolated mouse pancreatic islets in culture: Effects of serum and different culture media on the insulin production of the islets

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Insulin independence after islet transplantation into type I diabetic patient

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

The desensitization of normal B-cells to glucose in vitro is transient and not related to high glucose levels

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Determination of total serum insulin (IRI) in insulin-treated diabetic patients.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Effects of glucose on the ultrastructure and insulin biosynthesis of isolated mouse pancreatic islets maintained in tissue culture

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Severe diabetes induced in subtotally depancreatized dogs by sustained hyperglycemia.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Culture of mouse pancreatic islets in different glucose concentrations modifies B cell sensitivity to streptozotocin

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Effects of high glucose on insulin secretion by isolated rat islets and purified beta-cells and possible role of glycosylation

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Viable purified islets of Langerhans from collagenase-perfused human pancreas

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

In vitro exhaustion of pancreatic beta-cells

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Perturbation of pancreatic islet function in glucose-infused rats

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Coupling of beta-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Chronic in vivo hyperglycemia impairs phosphoinositide hydrolysis and insulin release in isolated perifused rat islets

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Prolonged exposure of pancreatic islets isolated from "pre-diabetic" non-obese diabetic mice to a high glucose concentration does not impair beta-cell function

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Normoglycaemia after transplantation of freshly isolated and cryopreserved pancreatic islets in type 1 (insulin-dependent) diabetes mellitus.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Monolayer Culture of Adult Rat Pancreatic Islets on Extracellular Matrix: Modulation of B-Cell Function by Chronic Exposure to High Glucose*

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Sustained insulin-induced remissions of juvenile diabetes by means of an external artificial pancreas

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Effects of high glucose concentrations on the insulin biosynthesis of rat pancreatic islets maintained for extended periods in tissue culture.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Characteristics of desensitization of insulin secretion in fully in vitro systems.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

Viability tests of cryopreserved endocrine pancreatic cells

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443168

The third phase of in vitro insulin secretion. Evidence for glucose insensitivity

4 November 2018

1 reference

12 December 2020

The transient effect of strict glycaemic control on B cell function in newly diagnosed Type 1 (insulin-dependent) diabetic patients

1 reference

12 December 2020

Impact of uncoupling glucose stimulus from secretion on B-cell release and biosynthesis

1 reference

12 December 2020

Abnormal sensitivity to glucose of human islets cultured in a high glucose medium: partial reversibility after an additional culture in a normal glucose medium

1 reference

12 December 2020

Compensatory capabilities of islets of BB/Wor rats exposed to sustained hyperglycemia

1 reference

12 December 2020

Sustained exposure of toxically damaged mouse pancreatic islets to high glucose does not increase beta-cell dysfunction

1 reference

12 December 2020

High-glucose stimulation of 64,000-Mr islet cell autoantigen expression

1 reference

12 December 2020

Can desensitization of the B-cell to D-glucose be simulated in cultured pancreatic islets?

1 reference

12 December 2020

An improved fluorometric assay for DNA

1 reference

12 December 2020

Long-term exposure of isolated pancreatic islets to mannoheptulose: evidence for insulin degradation in the beta cell

1 reference

12 December 2020

Lesions of the Pancreatic Islets Produced in Cats by Administration of Glucose

1 reference

12 December 2020

Long-term effects of a high glucose concentration in vitro on the oxidative metabolism and insulin production of isolated rat pancreatic islets

1 reference

12 December 2020

In vitro restoration of insulin production in islets from adult rats treated neonatally with streptozotocin

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI115989

1 reference

25 September 2017

1 reference

25 September 2017

1 reference

PMCID

443168