Genetically engineered cells stably expressing cytochrome P450 and their application to mutagen assays (Q41022840)

25 September 2017

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title

Genetically engineered cells stably expressing cytochrome P450 and their application to mutagen assays (English)

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25 September 2017

Sawada M

1

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25 September 2017

Kamataki T

series ordinal

2

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25 September 2017

language of work or name

English

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publication date

1 August 1998

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25 September 2017

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25 September 2017

volume

411

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25 September 2017

issue

1

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25 September 2017

page(s)

19-43

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Establishment of transgenic mice carrying human fetus-specific CYP3A7.

25 September 2017

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Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2

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Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster cells (V79) and metabolic activation of aflatoxin B1.

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7 January 2021

Transfection of a human cytochrome P-450 gene into the human lymphoblastoid cell line, AHH-1, and use of the recombinant cell line in gene mutation assays

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7 January 2021

Genetic toxicology using human cell lines expressing human P-450.

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7 January 2021

Development of a human lymphoblastoid cell line constitutively expressing human CYP1A1 cDNA: substrate specificity with model substrates and promutagens

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7 January 2021

Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells

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7 January 2021

Regio- and stereo-selective metabolism of phenanthrene by twelve cDNA-expressed human, rodent, and rabbit cytochromes P-450.

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7 January 2021

The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7,8-dihydrodiol

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7 January 2021

Expression of human cytochrome P450 1A1 in DNA repair deficient and proficient human fibroblasts stably transformed with an inducible expression vector

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7 January 2021

Cytotoxicity and genotoxicity of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol in CYP1A1-expressing human fibroblasts quantitatively correlate with CYP1A1 expression level.

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7 January 2021

Differential mutagenicity and cytotoxicity of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol and (+/-)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide in genetically engineered human fibroblasts.

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7 January 2021

Inhibition of cytochromes P4501A by nitric oxide

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7 January 2021

Stable expression of monkey cytochrome P-450IA1 cDNA in Chinese hamster CHL cells and its application for detection of mutagenicity of aflatoxin B1

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https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Stable expression of guinea pig NADPH-cytochrome P450 reductase and monkey P4501A1 cDNAs in Chinese hamster cells: establishment of cell lines highly sensitive to aflatoxin B [corrected]

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https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

High susceptibility to aflatoxin B1 and benzo[a]pyrene of BALB3T3 A31-1-1 cells expressing monkey CYP1A1.

1 reference

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7 January 2021

Applications of stable V79-derived cell lines expressing rat cytochromes P4501A1, 1A2, and 2B1

1 reference

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7 January 2021

The use of genetically engineered V79 Chinese hamster cultures expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus assays.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

A comparative study of the use of primary Chinese hamster liver cultures and genetically engineered immortal V79 Chinese hamster cell lines expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus assays.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Effects of benzo[a]pyrene and (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene on mitosis in Chinese hamster V79 cells with stable expression of rat cytochrome P4501A1 or 1A2.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Induction of micronuclei in V79 Chinese hamster cells by hydroquinone and econazole nitrate

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Clastogenicity of anthraquinones in V79 and in three derived cell lines expressing P450 enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

The cytotoxicity of mitomycin C and adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Development and validation of alternative metabolic systems for mutagenicity testing in short-term assays

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Expression of mouse cytochrome P450IA1 cDNA in repair-deficient and repair-proficient CHO cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Stable expression of human cytochrome P450IA2 cDNA in a human lymphoblastoid cell line: role of the enzyme in the metabolic activation of aflatoxin B1.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin B1 and comparison to CYP1A2 and CYP2A3.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Cytochrome P450-dependent metabolism of acetaminophen in four human transgenic lymphoblastoid cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Paracetamol-induced spindle disturbances in V79 cells with and without expression of human CYP1A2.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Activation of promutagens in a human bronchial epithelial cell line stably expressing human cytochrome P450 1A2.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation of 17β-estradiol and 2-aminofluorene in V79 Chinese hamster cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Metabolism of phenacetin in V79 Chinese hamster cell cultures expressing rat liver cytochrome P4501A2 compared to isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

The detection of promutagen activation by extracts of cells expressing cytochrome P450IA2 cDNA: preincubation dramatically increases revertant yield in the Ames test.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Cytochrome P4501A2 constitutively expressed from transduced DNA mediates metabolic activation and DNA-adduct formation of aromatic amine carcinogens in NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Introduction of cytochrome P450IA2 metabolic capability into cell lines genetically matched for DNA repair proficiency/deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Metabolic activation and cytogenetic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in Chinese hamster ovary cells expressing murine cytochrome P450 IA2

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Identification of aprt gene mutations induced in repair-deficient and P450-expressing CHO cells by the food-related mutagen/carcinogen, PhIP.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Genetically modified Chinese hamster ovary (CHO) cells for studying the genotoxicity of heterocyclic amines from cooked foods

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Development of a human cell line by selection and drug-metabolizing gene transfection with increased capacity to activate promutagens

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Human cytochrome P450IIA3: cDNA sequence, role of the enzyme in the metabolic activation of promutagens, comparison to nitrosamine activation by human cytochrome P450IIE1.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

N-nitrosodiethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced morphological transformation of C3H/10T1/2CL8 cells expressing human cytochrome P450 2A6

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Human CYP2A6 activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): mutational specificity in the gpt gene of AS52 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Study of coumarin metabolism by Chinese hamster lung fibroblasts expressing a human cytochrome P450 using H-nmr

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Genetically engineered V79 Chinese hamster cells metabolically activate the cytostatic drugs cyclophosphamide and ifosfamide

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Substrates of human hepatic cytochrome P450 3A4.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Transfection of a rat cytochrome P450b cDNA into C3H10T1/2CL8 mouse embryo fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Human cell lines, derived from AHH-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Characterization of a human cell line expressing high levels of cDNA-derived CYP2D6.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Oxidation of 1,2-epoxy-3-butene to 1,2:3,4-diepoxybutane by cDNA-expressed human cytochromes P450 2E1 and 3A4 and human, mouse and rat liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Mammalian PC-12 cell genetically engineered for human cytochrome P450 2E1 expression

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Ethanol increases content and activity of human cytochrome P4502E1 in a transduced HepG2 cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Stable expression of human CYP2E1 in Chinese hamster cells: high sensitivity to N,N-dimethylnitrosamine in cytotoxicity testing

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Rabbit P450 2E1 expressed in CHO-K1 cells has a short half-life

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

A NIH/3T3 cell line stably expressing human cytochrome P450-3A4 used in combination with a lacZ' shuttle vector to study mutagenicity

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Tiamulin inhibits human CYP3A4 activity in an NIH/3T3 cell line stably expressing CYP3A4 cDNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Genetically engineered mammalian cells and applications

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Stable expression of human cytochrome P450 3A4 in conjunction with human NADPH-cytochrome P450 oxidoreductase in V79 Chinese hamster cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Stable expression of human cytochrome P450 3A4 in V79 cells and its application for metabolic profiling of ergot derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Stable expression of cytochrome P450IIIA7 cDNA in human breast cancer cell line MCF-7 and its application to cytotoxicity testing.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Simultaneous expression of human CYP3A7 and N-acetyltransferase in Chinese hamster CHL cells results in high cytotoxicity for carcinogenic heterocyclic amines.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Mouse cytochrome P450 (Cyp3a11): predominant expression in liver and capacity to activate aflatoxin B1.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1).

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

4-Ipomeanol and 2-aminoanthracene cytotoxicity in C3H/10T1/2 cells expressing rabbit cytochrome P450 4B1.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Expression of xenobiotic-metabolizing enzymes in propagatable cell cultures and induction of micronuclei by 13 compounds

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Molecular cloning of monkey P450 1A1 cDNA and expression in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Monoclonal antibody-directed radioimmunoassay detects cytochrome P-450 in human placenta and lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Primary structure of a cytochrome P-450: coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 cDNA from rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Tissue-specific expression of rat mRNAs homologous to cytochromes P-450b and P-450e

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

A Constitutive Member of the Rat Cytochrome P450IIB Subfamily: Full-Length Coding Sequence of the P450IIB3 cDNA

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Androgen hydroxylation catalysed by a cell line (SD1) that stably expresses rat hepatic cytochrome P-450 PB-4 (IIB1)

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Purification and properties of cytochrome P-450 generally acting as a catalyst on benzo[a]pyrene hydroxylation from liver microsomes of untreated rats

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Genomic organization of human fetal specific P-450IIIA7 (cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5' flanking region

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Fetus-specific expression of a form of cytochrome P-450 in human livers

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Mutagenic activation of aflatoxin B1 by P-450 HFLa in human fetal livers.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Stable expression of rat cytochrome P450 11 beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) in MA-10 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Effect of androstenedione on growth of untransfected and aromatase-transfected MCF-7 cells in culture.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Structure-function studies of human aromatase by site-directed mutagenesis: kinetic properties of mutants Pro-308----Phe, Tyr-361----Phe, Tyr-361----Leu, and Phe-406----Arg

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

A comparison of chromosome aberration induction by 25 compounds tested by two Chinese hamster cell (CHL and CHO) systems in culture

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Reaction of N-hydroxylamine and N-acetoxy derivatives of 2-amino-3-methylimidazolo[4,5-f]quinoline with DNA. Synthesis and identification of N-(deoxyguanosin-8-yl)-IQ

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Acetyltransferase in humans: development and tissue distribution

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Micronucleus assays using cytochalasin-blocked MCL-5 cells, a proprietary human cell line expressing five human cytochromes P-450 and microsomal epoxide hydrolase

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

A genetically engineered V79 cell line SD1 expressing rat CYP2B1 exhibits chromosomal instability at the integration site of the transfected DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

Kinetics and inhibition by fluvoxamine of phenacetin O-deethylation in V79 cells expressing human CYP1A2.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2898%2900005-2

7 January 2021

10.1016/S1383-5742(98)00005-2

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DOI

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25 September 2017

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