Graft-versus-host disease and the Th1/Th2 paradigm (Q41062993)

26 September 2017

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title

Graft-versus-host disease and the Th1/Th2 paradigm (English)

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26 September 2017

W Krenger

1

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26 September 2017

J L Ferrara

series ordinal

2

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26 September 2017

language of work or name

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1 January 1996

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26 September 2017

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26 September 2017

15

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26 September 2017

1

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26 September 2017

50-73

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https://scigraph.springernature.com/pub.10.1007/bf02918284

26 September 2017

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cites work

Hyper IgE in stimulatory graft- versus-host disease: role of interleukin-4

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Crossref

https://api.crossref.org/works/10.1007%2FBF02918284

Graft-versus-host disease in experimental allogeneic bone marrow transplantation

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FBF02918284

Endogenous IFN-gamma during human bone marrow transplantation. Analysis of serum levels of interferon and interferon-dependent secondary messages

21 January 2018

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12 December 2020

Graft-versus-host disease induces expression of Ia antigen in rat epidermal cells and gut epithelium

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12 December 2020

Activation of mouse macrophages for tumor cell killing. I. Quantitative analysis of interactions between lymphokine and lipopolysaccharide.

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12 December 2020

Tumor necrosis factor: a pleiotropic cytokine and therapeutic target

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12 December 2020

Macrophage activation for tumor cytotoxicity: characterization of priming and trigger signals during lymphokine activation

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12 December 2020

IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity

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12 December 2020

Immunosuppression and lymphoid hypoplasia associated with chronic graft versus host disease is dependent upon IFN-gamma production

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12 December 2020

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones

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12 December 2020

High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

1 reference

12 December 2020

Interleukin-1 receptor antagonist

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12 December 2020

In vivo administration of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF, interleukin-1 (IL-1), and IL-4, alone and in combination, after allogeneic murine hematopoietic stem cell transplantation

1 reference

12 December 2020

IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease

1 reference

12 December 2020

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12 December 2020

An endotoxin-induced serum factor that causes necrosis of tumors

1 reference

12 December 2020

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles

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12 December 2020

Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens

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12 December 2020

Critical issues in bone marrow transplantation

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12 December 2020

Nitric oxide--a new endogenous immunomodulator.

1 reference

12 December 2020

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

1 reference

12 December 2020

Involvement of IFN-gamma and transforming growth factor-beta in graft-vs-host reaction-associated immunosuppression

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12 December 2020

Critical role of interleukin-2 in the development of acute graft-versus-host disease.

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12 December 2020

Th2 cells mediate IL-4-dependent local tissue inflammation

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12 December 2020

Lymphokine production by T-cell clones after human bone marrow transplantation.

1 reference

12 December 2020

Lymphocyte responses and cytokines

1 reference

12 December 2020

An IL-1 inhibitor from human monocytes. Production and characterization of biologic properties

1 reference

12 December 2020

Heterogeneity of cytokine secretion patterns and functions of helper T cells

1 reference

12 December 2020

Macrophage activation by T cells: cognate and non-cognate signals

1 reference

12 December 2020

In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftment

1 reference

12 December 2020

Regulation of murine macrophage Ia-antigen expression by products of activated spleen cells

1 reference

12 December 2020

Th1 and Th2 subsets: paradigms lost?

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12 December 2020

Anti-IL-4 antibody prevents graft-versus-host disease in mice after bone marrow transplantation. The IgE allotype is an important marker of graft-versus-host disease.

1 reference

12 December 2020

Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway

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12 December 2020

Host-specific interleukin-2-secreting donor T-cell precursors as predictors of acute graft-versus-host disease in bone marrow transplantation between HLA-identical siblings

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12 December 2020

A phase I-II study evaluating the murine anti-IL-2 receptor antibody 2A3 for treatment of acute graft-versus-host disease

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12 December 2020

Nitric oxide synthases: Roles, tolls, and controls

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12 December 2020

Cytokine dysregulation as a mechanism of graft versus host disease

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12 December 2020

Repopulation of host lymphohematopoietic systems by donor cells during graft-versus-host reaction in unirradiated adult F1 mice injected with parental lymphocytes

1 reference

12 December 2020

Effect of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graft-versus-host disease in H-2-incompatible transplanted SCID mice

1 reference

12 December 2020

IL-4 directs the development of Th2-like helper effectors

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12 December 2020

Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice

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12 December 2020

Immunomodulatory and antimicrobial efficacy of intravenous immunoglobulin in bone marrow transplantation

1 reference

12 December 2020

Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts

1 reference

12 December 2020

Antibodies to IFN-gamma prevent immunologically mediated intestinal damage in murine graft-versus-host reaction

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12 December 2020

Cyclosporine in allogeneic bone marrow transplantation

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12 December 2020

Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection

1 reference

12 December 2020

A possible novel pathway of regulation by murine T helper type-2 (Th2) cells of a Th1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages

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12 December 2020

Nitric oxide mediates intestinal pathology in graft-vs.-host disease

1 reference

12 December 2020

Role of tumor necrosis factor alpha in acute graft-versus-host disease and complications following allogeneic bone marrow transplantation

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12 December 2020

Lymphocyte-mediated cytotoxicity: two pathways and multiple effector molecules

1 reference

12 December 2020

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

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12 December 2020

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12 December 2020

Clinical and immunologic effects of prolonged infusion of low-dose recombinant interleukin-2 after autologous and T-cell-depleted allogeneic bone marrow transplantation

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12 December 2020

Influences of interleukins 2 and 4 on tumor necrosis factor production by murine mononuclear phagocytes.

1 reference

12 December 2020

Lethal graft-versus-host disease in mice directed to multiple minor histocompatibility antigens: features of CD8+ and CD4+ T cell responses

1 reference

12 December 2020

Human Th1 and Th2 cells: functional properties, mechanisms of regulation, and role in disease

1 reference

12 December 2020

Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation

1 reference

12 December 2020

Frequency analysis of lymphokine-secreting CD4+ and CD8+ T cells activated in a graft-versus-host reaction

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12 December 2020

Inhibition of nitric oxide synthesis by interleukin‐4 may involve inhibiting the activation of protein kinase C epsilon

1 reference

12 December 2020

Preferential activation of Th2 cells in chronic graft-versus-host reaction

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12 December 2020

Demonstration of direct involvement of cytokines in graft-versus-host reactions using an in vitro human skin explant model

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12 December 2020

Production of IL-1 and its receptor antagonist is regulated differently by IFN-gamma and IL-4 in human monocytes and alveolar macrophages

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12 December 2020

Macrophages as a source of tumoricidal activity (tumor-necrotizing factor).

1 reference

12 December 2020

Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis

1 reference

12 December 2020

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.

1 reference

12 December 2020

IL-2 inhibits early increases in serum gamma interferon levels associated with graft-versus-host-disease

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12 December 2020

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

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12 December 2020

Kinetics of T cell activation in acute and chronic forms of murine graft-versus-host disease

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12 December 2020

T-cell depletion of allogeneic bone marrow prevents acceleration of graft-versus-host disease induced by exogenous interleukin 2

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12 December 2020

Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia

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12 December 2020

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

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12 December 2020

Interleukin 1 increases the binding of human B and T lymphocytes to endothelial cell monolayers

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12 December 2020

Role of tumour necrosis factor-alpha in dendritic cell-mediated primary mixed leucocyte reactions

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12 December 2020

Apoptosis of murine large intestine in acute graft-versus-host disease after allogeneic bone marrow transplantation across minor histocompatibility barriers

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12 December 2020

Interleukin-2 inhibits graft-versus-host disease-promoting activity of CD4+ cells while preserving CD4- and CD8-mediated graft-versus-leukemia effects.

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12 December 2020

Lymphokine production by human T cells in disease states

1 reference

12 December 2020

Effects of interferon-gamma and tumor necrosis factor-alpha on the expression of an Ia antigen on a murine macrophage cell line

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12 December 2020

CD8+ T cells can be primed in vitro to produce IL-4

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12 December 2020

Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases

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12 December 2020

Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in mice

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12 December 2020

Inhibition of the reactive proliferation of lymphocytes by activated macrophages: the role of nitric oxide

1 reference

12 December 2020

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells

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12 December 2020

The functional role of CD8+ T helper type 2 cells

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12 December 2020

Interleukin 10 protects mice from lethal endotoxemia

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12 December 2020

Effects of tumor necrosis factor on the interferon-gamma-induced major histocompatibility complex class II antigen expression by human endothelial cells

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12 December 2020

Cytokine dysregulation and acute graft-versus-host disease

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12 December 2020

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

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12 December 2020

Interleukin-1 is a critical effector molecule during cytokine dysregulation in graft versus host disease to minor histocompatibility antigens

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12 December 2020

Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon

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12 December 2020

Regulation by interferons of the local inflammatory response to bacterial lipopolysaccharide

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12 December 2020

Lethal murine graft-versus-host disease in the absence of detectable cytotoxic T lymphocytes

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12 December 2020

Graft-versus-host disease

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12 December 2020

Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat

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12 December 2020

Treatment of corticosteroid resistant acute graft-versus-host disease by in vivo administration of anti-interleukin-2 receptor monoclonal antibody (B-B10)

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12 December 2020

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

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12 December 2020

Effects of exogenous interleukin-10 in a murine model of graft-versus-host disease to minor histocompatibility antigens

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12 December 2020

Interleukin-12 and its role in the generation of TH1 cells

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12 December 2020

Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation?

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12 December 2020

Differential cytokine expression in acute and chronic murine graft-versus-host-disease

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12 December 2020

Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase

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12 December 2020

The role of tumor necrosis factor and interferon gamma in graft-versus-host disease and related immunodeficiency

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12 December 2020

Role of immunosuppressive drugs for prevention of graft-v-host disease after human HLA matched bone marrow transplantation

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12 December 2020

The role of cytokines in graft-versus-host reactions and disease

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12 December 2020

Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantation

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12 December 2020

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin

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12 December 2020

IL-12: initiation cytokine for cell-mediated immunity

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12 December 2020

Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease

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12 December 2020

Enumeration of lymphokine mRNA-containing cells in vivo in a murine graft-versus-host reaction using the PCR.

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12 December 2020

Quantitative analysis of lymphokine expression in vivo and in vitro

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12 December 2020

Induction of the synthesis of tumor necrosis factor receptors by interferon-gamma

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12 December 2020

Graft-versus-host reactions in the beige mouse. An investigation of the role of host and donor natural killer cells in the pathogenesis of graft-versus-host disease

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12 December 2020

Shock and tissue injury induced by recombinant human cachectin

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12 December 2020

T cell depletion of HLA and haploidentical marrow reduces graft-versus-host disease but it may impair a graft-versus-leukemia effect

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12 December 2020

Interleukin (IL) 4 differentially regulates monocyte IL-1 family gene expression and synthesis in vitro and in vivo

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12 December 2020

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

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12 December 2020

Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor alpha during graft-versus-host disease

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12 December 2020

Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease

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12 December 2020

Suppression of B-cell proliferation to lipopolysaccharide is mediated through induction of the nitric oxide pathway by tumor necrosis factor-alpha in mice with acute graft-versus-host disease

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12 December 2020

Immunodeficiency in graft-versus-host disease. I. Mechanism of immune suppression

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12 December 2020

Effects of in vivo administration of interferon (IFN)-gamma, anti-IFN-gamma, or anti-interleukin-4 monoclonal antibodies in chronic autoimmune graft-versus-host disease

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12 December 2020

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production

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12 December 2020

A common precursor for CD4+ T cells producing IL-2 or IL-4

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12 December 2020

Mortality and gross pathology of secondary disease in germfree mouse radiation chimeras

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12 December 2020

Interleukin-2 toxicity

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12 December 2020

Risk factors for acute graft-versus-host disease

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12 December 2020

Management of graft-versus-host disease

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12 December 2020

Gamma interferon priming of mouse and human macrophages for induction of tumor necrosis factor production by bacterial lipopolysaccharide

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12 December 2020

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

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12 December 2020

Inhibition of nitric oxide production is associated with enhanced weight loss, decreased survival, and impaired alloengraftment in mice undergoing graft-versus-host disease after bone marrow transplantation

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12 December 2020

Role of T cell subsets in lethal graft-versus-host disease (GVHD) directed to class I versus class II H-2 differences. II. Protective effects of L3T4+ cells in anti-class II GVHD

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12 December 2020

Human TH1 and TH2 subsets: doubt no more

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12 December 2020

T lymphocyte subsets, cytokines, and effector functions

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12 December 2020

Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. Regulation of cytokines and CD8+ lymphoid engraftment

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12 December 2020

Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages

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12 December 2020

Evidence that nitric oxide production by in vivo allosensitized cells inhibits the development of allospecific CTL

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12 December 2020

Pneumopathies of the graft-versus-host reaction. Alveolitis associated with an increased level of tumor necrosis factor mRNA and chronic interstitial pneumonitis.

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12 December 2020

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets

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12 December 2020

Non-cytotoxic, IL-4, IL-5, IL-10 producing CD8+ T cells: their activation and effector functions.

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12 December 2020

Nitric oxide-induced anti-mitogenic effects in high and low responder rat strains

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12 December 2020

Amelioration of acute graft vs host disease due to minor histocompatibility antigens by in vivo administration of anti-interleukin 2 receptor antibody

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12 December 2020

IL-1 receptor antagonist and IL-1 beta production in human monocytes are regulated differently

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12 December 2020

Mitigation of secondary disease of allogeneic mouse radiation chimeras by modification of the intestinal microflora

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12 December 2020

Cytokine storm of graft-versus-host disease: a critical effector role for interleukin-1.

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12 December 2020

Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells

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12 December 2020

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease

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12 December 2020

IL-2 reduces graft-versus-host disease and preserves a graft-versus-leukemia effect by selectively inhibiting CD4+ T cell activity

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12 December 2020

Quantitative assessment of posttransplant host-specific interleukin-2-secreting T-helper cell precursors in patients with and without acute graft-versus-host disease after allogeneic HLA-identical sibling bone marrow transplantation

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12 December 2020

Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells. The contribution of vascular cell adhesion molecule-1-dependent and -independent binding mechanisms

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12 December 2020

Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma

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12 December 2020

Cytokine gene expression in mice undergoing chronic graft-versus-host disease

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12 December 2020

Interleukin-1 and interleukin-1 antagonism

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12 December 2020

Characterization of the immunosuppressive effects of nitric oxide in graft vs host disease

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12 December 2020

Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells

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12 December 2020

Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine

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12 December 2020

Molecular regulation of the IL-2 gene: rheostatic control of the immune system

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12 December 2020

Use of an anti-interleukin-2 receptor monoclonal antibody for GVHD prophylaxis in unrelated donor BMT

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12 December 2020

Evidence that IFN-gamma is responsible for natural suppressor activity in GVHD spleen and normal bone marrow

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12 December 2020

Frequency of anti-recipient alloreactive helper T-cell precursors in donor blood and graft-versus-host disease after HLA-identical sibling bone-marrow transplantation

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12 December 2020

Role of cytokines and major histocompatibility complex antigens in graft-versus-host disease: in vitro studies using T-cell lines and keratinocytes or hemopoietic targets

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12 December 2020

Acquisition of lymphokine-producing phenotype by CD4+ T cells

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12 December 2020

A study of cytokine production in acute graft-vs-host disease

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12 December 2020

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells

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12 December 2020

Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8+ T cells

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12 December 2020

Graft failure in patients receiving T cell-depleted HLA-identical allogeneic marrow transplants

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12 December 2020

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones

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12 December 2020

Identifiers

DOI

10.1007/BF02918284

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Dimensions Publication ID

26 September 2017

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