Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivo (Q41078859)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8978697%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

title

Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivo (English)

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22 October 2019

author name string

D Krappmann

series ordinal

1

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22 October 2019

F G Wulczyn

series ordinal

2

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22 October 2019

C Scheidereit

series ordinal

3

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22 October 2019

language of work or name

English

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publication date

1 December 1996

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22 October 2019

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22 October 2019

volume

15

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22 October 2019

issue

23

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22 October 2019

page(s)

6716-6726

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Constitutive phosphorylation of IkappaBalpha by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IkappaBalpha

22 October 2019

cites work

1 reference

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Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability

26 September 2017

1 reference

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Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

26 September 2017

1 reference

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Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation

26 September 2017

1 reference

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Both amino- and carboxyl-terminal sequences within I kappa B alpha regulate its inducible degradation

26 September 2017

1 reference

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Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

26 September 2017

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Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of I kappa B-alpha

26 September 2017

1 reference

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Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells.

26 September 2017

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Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation

26 September 2017

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The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B

26 September 2017

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Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B

26 September 2017

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Common structural constituents confer I kappa B activity to NF-kappa B p105 and I kappa B/MAD-3.

26 September 2017

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Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.

26 September 2017

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Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family

26 September 2017

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Proteolytic degradation of MAD3 (I kappa B alpha) and enhanced processing of the NF-kappa B precursor p105 are obligatory steps in the activation of NF-kappa B.

26 September 2017

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The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors

26 September 2017

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In vivo control of NF-kappa B activation by I kappa B alpha.

26 September 2017

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Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines

26 September 2017

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NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway

26 September 2017

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Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

26 September 2017

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

26 September 2017

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Function and activation of NF-kappa B in the immune system

26 September 2017

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Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors

26 September 2017

1 reference

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A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B

26 September 2017

1 reference

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Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha

26 September 2017

1 reference

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Activation of NF-kappa B in vivo is regulated by multiple phosphorylations

26 September 2017

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Structure, regulation and function of NF-kappa B

26 September 2017

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Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

26 September 2017

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26 September 2017

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Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B

26 September 2017

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In vivo stimulation of I kappa B phosphorylation is not sufficient to activate NF-kappa B

26 September 2017

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26 September 2017

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Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B

26 September 2017

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The PEST-like sequence of I kappa B alpha is responsible for inhibition of DNA binding but not for cytoplasmic retention of c-Rel or RelA homodimers

26 September 2017

1 reference

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Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B

26 September 2017

1 reference

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Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli

26 September 2017

1 reference

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Overexpression of RelA in transgenic mouse thymocytes: specific increase in levels of the inhibitor protein I kappa B alpha

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452495

Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452495

Inducible degradation of I kappa B alpha in vitro and in vivo requires the acidic C-terminal domain of the protein

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452495

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

26 September 2017

1 reference

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Cactus protein degradation mediates Drosophila dorsal-ventral signaling

26 September 2017

1 reference

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Constitutive phosphorylation of I kappa B alpha by casein kinase II

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452495

A role for phosphorylation and degradation in the control of NF-κB activity

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452495

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

26 September 2017

1 reference

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Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice

26 September 2017

1 reference

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Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

26 September 2017

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N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity

26 September 2017

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Mechanistic aspects of NF-kappa B regulation: the emerging role of phosphorylation and proteolysis

26 September 2017

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Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

26 September 2017

1 reference

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Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452495

Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism

26 September 2017

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Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis

26 September 2017

1 reference

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Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

26 September 2017

1 reference

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Direct association of pp40/I kappa B beta with rel/NF-kappa B transcription factors: role of ankyrin repeats in the inhibition of DNA binding activity

26 September 2017

1 reference

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Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation

26 September 2017

1 reference

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Inactivation of NF-kappa B inhibitor I kappa B alpha: ubiquitin-dependent proteolysis and its degradation product

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452495

The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms

26 September 2017

1 reference

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Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo

14 June 2018

1 reference

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The ankyrin repeats but not the PEST-like sequences are required for signal-dependent degradation of IkappaBalpha

19 August 2018

1 reference

12 December 2020

I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B

1 reference

12 December 2020

High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells

1 reference

12 December 2020

Ubiquitinylation is not an absolute requirement for degradation of c-Jun protein by the 26 S proteasome

1 reference

12 December 2020

10.1002/J.1460-2075.1996.TB01061.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8978697%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8978697%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

PubMed publication ID

8978697

1 reference