Nucleoside analogues previously found to be inactive against HIV may be activated by simple chemical phosphorylation (Q41079192)

26 September 2017

title

Nucleoside analogues previously found to be inactive against HIV may be activated by simple chemical phosphorylation (English)

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26 September 2017

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McGuigan C

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Kinchington D

2

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Wang MF

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Nicholls SR

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Nickson C

5

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Galpin S

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Jeffries DJ

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O'Connor TJ

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language of work or name

English

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publication date

1 May 1993

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26 September 2017

volume

322

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issue

3

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page(s)

249-252

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Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

26 September 2017

cites work

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Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

21 January 2018

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Synthesis and anti-HIV activity of some haloalkyl phosphoramidate derivatives of 3'-azido-3'-deoxythymidine (AZT): potent activity of the trichloroethyl methoxyalaninyl compound

21 January 2018

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Aryl phosphate derivatives of AZT retain activity against HIV1 in cell lines which are resistant to the action of AZT

21 January 2018

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Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells

21 January 2018

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Lipophilic glycosyl phosphotriester derivatives of AZT: synthesis, NMR transmembrane transport study, and antiviral activity

21 January 2018

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3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents

21 January 2018

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HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy

21 January 2018

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Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects

21 January 2018

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Specificity of esterases and structure of prodrug esters. II. Hydrolytic regeneration behavior of 5-fluoro-2'-deoxyuridine (FUdR) from 3',5'-diesters of FUdR with rat tissue homogenates and plasma in relation to their antitumor activity

21 January 2018

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Comparison of antigen capture assays against HIV-1 in evaluating antiviral compounds

21 January 2018

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Species- or isozyme-specific enzyme inhibitors. 5. Differential effects of thymidine substituents on affinity for rat thymidine kinase isozymes

21 January 2018

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10.1016/0014-5793(93)81580-S

21 January 2018

Identifiers

DOI

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26 September 2017

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