Genetic variation in the cholesterol transporter NPC1L1, ischaemic vascular disease, and gallstone disease (Q41115755)

26 September 2017

Genetic variation in the cholesterol transporter NPC1L1, ischaemic vascular disease, and gallstone disease (English)

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26 September 2017

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Børge G. Nordestgaard

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4

object named as

Børge G Nordestgaard

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Anne Tybjærg-Hansen

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5

object named as

Anne Tybjærg-Hansen

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26 September 2017

3

Ruth Frikke-Schmidt

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26 September 2017

1

Bo Kobberø Lauridsen

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26 September 2017

2

Stefan Stender

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26 September 2017

4 April 2015

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26 September 2017

European Heart Journal

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26 September 2017

36

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26 September 2017

25

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26 September 2017

1601-1608

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Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials

26 September 2017

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https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes: the SANDS (Stop Atherosclerosis in Native Diabetics Study) trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Simvastatin with or without ezetimibe in familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Extended-release niacin or ezetimibe and carotid intima-media thickness.

21 January 2018

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https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

21 January 2018

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https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

The ezetimibe controversy: implications for clinical practice

21 January 2018

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https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Cholesterol gallstone disease.

21 January 2018

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https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Loss-of-function mutations in APOC3 and risk of ischemic vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Genetic inhibition of CETP, ischemic vascular disease and mortality, and possible adverse effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Discovery and refinement of loci associated with lipid levels

21 January 2018

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https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

An NPC1L1 gene promoter variant is associated with autosomal dominant hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

The g.-762T>C polymorphism of the NPC1L1 gene is common in Chinese and contributes to a higher promoter activity and higher serum cholesterol levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Modulation of human Niemann-Pick C1-like 1 gene expression by sterol: Role of sterol regulatory element binding protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Remnant cholesterol as a causal risk factor for ischemic heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

The ABCG5/8 cholesterol transporter and myocardial infarction versus gallstone disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

New pathophysiological concepts underlying pathogenesis of pigment gallstones

21 January 2018

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https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Extreme bilirubin levels as a causal risk factor for symptomatic gallstone disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Inactivating mutations in NPC1L1 and protection from coronary heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Statin use and risk of gallstone disease followed by cholecystectomy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Statin use and the risk of cholecystectomy in women

21 January 2018

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https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Liver-specific induction of Abcg5 and Abcg8 stimulates reverse cholesterol transport in response to ezetimibe treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Ezetimibe prevents cholesterol gallstone formation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEURHEARTJ%2FEHV108

21 January 2018

Identifiers

DOI

10.1093/EURHEARTJ/EHV108

1 reference

26 September 2017

1 reference

PubMed ID

25841872