1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors (Q41139696)

27 September 2017

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title

1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors (English)

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27 September 2017

R K Jain

1

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27 September 2017

1 July 1996

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Annals of Biomedical Engineering

27 September 2017

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27 September 2017

24

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27 September 2017

4

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27 September 2017

457-473

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https://scigraph.springernature.com/pub.10.1007/bf02648108

27 September 2017

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cites work

Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02648108

Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02648108

Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02648108

Effect of hyperthermia on microvascular permeability to macromolecules in normal and tumor tissues.

21 January 2018

1 reference

12 December 2020

Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity

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12 December 2020

Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure.

1 reference

12 December 2020

Measurement of mass transport and reaction parameters in bulk solution using photobleaching. Reaction limited binding regime

1 reference

12 December 2020

Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer

1 reference

12 December 2020

Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft

1 reference

12 December 2020

Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft

1 reference

12 December 2020

Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia

1 reference

12 December 2020

Microvascular permeability of normal and neoplastic tissues

1 reference

12 December 2020

Leukocyte rolling increases with age

1 reference

12 December 2020

Barriers to drug delivery in solid tumors

1 reference

12 December 2020

Extravascular diffusion in normal and neoplastic tissues

1 reference

12 December 2020

2H-nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma

1 reference

12 December 2020

Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation.

1 reference

12 December 2020

The implications of angiogenesis for the biology and therapy of cancer metastasis

1 reference

12 December 2020

Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies

1 reference

12 December 2020

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.

1 reference

12 December 2020

Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis

1 reference

12 December 2020

Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia

1 reference

12 December 2020

Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays

1 reference

12 December 2020

Reduction of rigidity in human activated natural killer cells by thioglycollate treatment.

1 reference

12 December 2020

Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation

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12 December 2020

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1 reference

12 December 2020

Determinants of tumor blood flow: a review

1 reference

12 December 2020

Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice

1 reference

12 December 2020

Kinetics of interleukin-2 induced changes in rigidity of human natural killer cells

1 reference

12 December 2020

Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response

1 reference

12 December 2020

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft

1 reference

12 December 2020

Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications

1 reference

12 December 2020

Fluid and protein fluxes across small and large pores in the microvasculature. Application of two-pore equations

1 reference

12 December 2020

Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response

1 reference

12 December 2020

Tissue perfusion inhomogeneity during early tumor growth in rats

1 reference

12 December 2020

Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.

1 reference

12 December 2020

Differential response of normal and tumor microcirculation to hyperthermia.

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12 December 2020

Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment

1 reference

12 December 2020

Interstitial fluid pressure in breast cancer, benign breast conditions, and breast parenchyma

1 reference

12 December 2020

Transport of molecules in the tumor interstitium: a review

1 reference

12 December 2020

Scale-invariant behavior and vascular network formation in normal and tumor tissue

1 reference

12 December 2020

Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia.

1 reference

12 December 2020

Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection

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12 December 2020

Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: implications for vascular leak syndrome

1 reference

12 December 2020

Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement

1 reference

12 December 2020

Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics

1 reference

12 December 2020

Interstitial hypertension in superficial metastatic melanomas in humans

1 reference

12 December 2020

Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data

1 reference

12 December 2020

Interstitial hypertension in head and neck tumors in patients: correlation with tumor size.

1 reference

12 December 2020

Dynamics of neovascularization in normal tissue.

1 reference

12 December 2020

Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model

1 reference

12 December 2020

Interstitial hypertension in human breast and colorectal tumors

1 reference

12 December 2020

Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia

1 reference

12 December 2020

Imaging of activated natural killer cells in mice by positron emission tomography: preferential uptake in tumors

1 reference

12 December 2020

Suppressive effect of basic fibroblast growth factor on transendothelial emigration of CD4(+) T-lymphocyte.

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12 December 2020

Microcirculatory flow changes during tissue growth

1 reference

12 December 2020

1 reference

12 December 2020

Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution

1 reference

12 December 2020

Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching

1 reference

12 December 2020

Endothelial adhesiveness for blood neutrophils is inhibited by transforming growth factor-beta

1 reference

12 December 2020

Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy

1 reference

12 December 2020

Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse

1 reference

12 December 2020

Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier

1 reference

12 December 2020

Hindered diffusion in agarose gels: test of effective medium model

1 reference

12 December 2020

Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy

1 reference

12 December 2020

Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery

1 reference

12 December 2020

Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media

1 reference

12 December 2020

Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory

1 reference

12 December 2020

Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR.

1 reference

12 December 2020

Extracellular water measurements: organ tracer kinetics of bromide and sucrose in rats and man.

1 reference

12 December 2020

Physiologically Based Pharmacokinetic Modeling: Principles and Applications

1 reference

12 December 2020

Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model

1 reference

12 December 2020

Leukocyte-endothelial adhesion and angiogenesis in tumors

1 reference

12 December 2020

Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain

1 reference

12 December 2020

Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications.

1 reference

12 December 2020

Diffusion and convection in normal and neoplastic tissues

1 reference

12 December 2020

Fluorescence ratio imaging measurement of pH gradients: calibration and application in normal and tumor tissues

1 reference

12 December 2020

Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation

1 reference

12 December 2020

Pharmacokinetics of methotrexate in solid tumors.

1 reference

12 December 2020

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure

1 reference

12 December 2020

Transforming growth factor-beta inhibits E-selectin expression on human endothelial cells

1 reference

12 December 2020

Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice

1 reference

12 December 2020

Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism

1 reference

12 December 2020

Kinetics of adhesion molecule expression and spatial organization using targeted sampling fluorometry

1 reference

12 December 2020

Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure

1 reference

12 December 2020

Tissue-isolated human tumor xenografts in athymic nude mice

1 reference

12 December 2020

Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice

1 reference

12 December 2020

Suppression of tumor growth in vivo by local and systemic 90K level increase

1 reference

12 December 2020

Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: changes during treatment

1 reference

12 December 2020

Transport of molecules across tumor vasculature

1 reference

12 December 2020

Delivery of novel therapeutic agents in tumors: physiological barriers and strategies

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12 December 2020

Low deformability of lymphokine-activated killer cells as a possible determinant of in vivo distribution.

1 reference

12 December 2020

In vitro measurement and screening of monoclonal antibody affinity using fluorescence photobleaching

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12 December 2020

Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes

1 reference

12 December 2020

Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin

1 reference

12 December 2020

Flow velocity in the superficial lymphatic network of the mouse tail

1 reference

12 December 2020

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis

1 reference

12 December 2020

Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice

1 reference

12 December 2020

Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching

1 reference

12 December 2020

Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution.

1 reference

12 December 2020

Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions

1 reference

12 December 2020

Diffusion and partitioning of proteins in charged agarose gels

1 reference

12 December 2020

A method for labeling cells for positron emission tomography (PET) studies

1 reference

12 December 2020

Measurement of capillary filtration coefficient in a solid tumor

1 reference

12 December 2020

Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice

1 reference

12 December 2020

Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.

1 reference

12 December 2020

Effect of glucose and galactose on red blood cell membrane deformability

1 reference

12 December 2020

Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.

1 reference

12 December 2020

Endothelial cell adhesiveness for human T lymphocytes is inhibited by transforming growth factor-beta 1

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF02648108

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PubMed ID

8841721

Dimensions Publication ID

27 September 2017

0 references

1 reference

PubMed ID

8841721