Cell type specific and inducible promoters for vectors in gene therapy as an approach for cell targeting (Q41139949)

27 September 2017

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title

Cell type specific and inducible promoters for vectors in gene therapy as an approach for cell targeting (English)

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27 September 2017

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W Walther

1

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PubMed ID

8841950

27 September 2017

U Stein

series ordinal

2

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27 September 2017

1 July 1996

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Journal of Molecular Medicine

27 September 2017

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27 September 2017

74

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27 September 2017

7

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27 September 2017

379-392

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Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression

27 September 2017

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Gene therapy for cancer using tumour-specific prodrug activation

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Hepatic gene transfer in animals using retroviruses containing the promoter from the gene for phosphoenolpyruvate carboxykinase

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Regulation of the phosphoenolpyruvate carboxykinase/human factor IX gene introduced into the livers of adult rats by receptor-mediated gene transfer.

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Molecular cloning and characterization of the promoter region of the calcineurin A alpha gene

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Factors controlling the expression of mouse mammary tumour virus

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Direct retroviral-mediated transfer of a dystrophin minigene into mdx mouse muscle in vivo

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Position-independent, high-level expression of the human beta-globin gene in transgenic mice

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Evaluation of Relative Promoter Strength in Primary Hepatocytes Using Optimized Lipofection

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Cells induced to express a human immunodeficiency virus type 1 envelope gene mutant inhibit the spread of wild-type virus

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

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Selective killing of CD4+ cells harboring a human immunodeficiency virus-inducible suicide gene prevents viral spread in an infected cell population

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Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor

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Isolation of an X-ray-responsive element in the promoter region of tissue-type plasminogen activator: potential uses of X-ray-responsive elements for gene therapy.

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Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy

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Targeting retroviral integration

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Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes

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Human immunodeficiency virus vectors for inducible expression of foreign genes

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Point mutations in the mdr1 promoter of human osteosarcomas are associated with in vitro responsiveness to multidrug resistance relevant drugs

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Carcinoembryonic antigen gene family: molecular biology and clinical perspectives

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Human cystic fibrosis transmembrane conductance regulator directed to respiratory epithelial cells of transgenic mice

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Expression of a whey acidic protein transgene during mammary development. Evidence for different mechanisms of regulation during pregnancy and lactation.

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Hormonal control of interacting promoters introduced into cells by retroviruses

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Generation of a transgenic model for retrovirus-mediated gene therapy for hepatocellular carcinoma is thwarted by the lack of transgene expression

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Retroviral-mediated transfer of genomic globin genes leads to regulated production of RNA and protein

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Functional identification of the transcriptional regulatory elements within the promoter region of the human ventricular myosin alkali light chain gene

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T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years.

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Direct gene transfer into mouse muscle in vivo

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Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter

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Surfactant protein A-directed toxin gene kills lung cancer cells in vitro

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The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression

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Expression of the diphtheria toxin A-chain coding sequence under the control of promoters and enhancers from immunoglobulin genes as a means of directing toxicity to B-lymphoid cells.

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Cis-active elements controlling lung cell-specific expression of human pulmonary surfactant protein B gene

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Use of the stress-inducible grp78/BiP promoter in targeting high level gene expression in fibrosarcoma in vivo.

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Spatial and temporal control of gene therapy using ionizing radiation

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Strategy for achieving selective killing of carcinomas

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Selective induction of toxicity to human cells expressing human immunodeficiency virus type 1 Tat by a conditionally cytotoxic adenovirus vector

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The development and testing of retroviral vectors expressing trans-dominant mutants of HIV-1 proteins to confer anti-HIV-1 resistance

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The immunopathogenesis of human immunodeficiency virus infection

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Transcriptional regulation of multigene loci: multilevel control

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Pseudotyped retroviral vectors for studies of human gene therapy

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Tissue-specific targeting of retroviral vectors through ligand-receptor interactions

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High-level beta-globin expression after retroviral transfer of locus activation region-containing human beta-globin gene derivatives into murine erythroleukemia cells

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Cystic fibrosis: molecular biology and therapeutic implications

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Targeting of retroviral vectors for gene therapy

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Identification and sequence analysis of the promoter for the leukocyte integrin beta-subunit (CD18): a retinoic acid-inducible gene

1 reference

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The 5'-flanking region of the synapsin I gene. A G+C-rich, TATA- and CAAT-less, phylogenetically conserved sequence with cell type-specific promoter function

1 reference

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Hormonal regulation of chimeric genes containing the phosphoenolpyruvate carboxykinase promoter regulatory region in hepatoma cells infected by murine retroviruses

1 reference

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Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter

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Inhibition of human immunodeficiency virus-1 production resulting from transduction with a retrovirus containing an HIV-regulated diphtheria toxin A chain gene

1 reference

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Transcriptional Regulatory Sequences of Carcinoembryonic Antigen: Identification and Use with Cytosine Deaminase for Tumor-Specific Gene Therapy

1 reference

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Identification of the promoter of the myelomonocytic leukocyte integrin CD11b

1 reference

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The direct activation of human multidrug resistance gene (MDR1) by anticancer agents

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Tissue-specific expression and dietary regulation of a chimeric phosphoenolpyruvate carboxykinase/bovine growth hormone gene in transgenic mice

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Regulated high-level human beta-globin gene expression in erythroid cells following recombinant adeno-associated virus-mediated gene transfer.

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Conditional expression of human TNF-alpha: a system for inducible cytotoxicity

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Gene therapy in peripheral blood lymphocytes and bone marrow for ADA- immunodeficient patients

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Bone marrow transplant for the haemoglobinopathies: past, present and future

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Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment

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Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.

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Gene therapy via primary myoblasts: long-term expression of factor IX protein following transplantation in vivo

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Liver-directed gene therapy: evaluation of liver specific promoter elements

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Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene.

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In vitro and in vivo targeting of gene expression to melanoma cells

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Intracellular antibodies as a new class of therapeutic molecules for gene therapy

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High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region

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Expression of the cystic fibrosis gene in adult human lung

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Skeletal muscle as a target for gene therapy

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Liver-directed gene therapy: prospects and problems

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A retroviral vector containing a muscle-specific enhancer drives gene expression only in differentiated muscle fibers

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12 December 2020

A novel transcription factor, OB2-1, is required for overexpression of the proto-oncogene c-erbB-2 in mammary tumour lines

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Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector

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Expression from leukocyte integrin promoters in retroviral vectors

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Resistance to human immunodeficiency virus type 1 (HIV-1) infection in human CD4+ lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme.

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A Rev-inducible mutant gag gene stably transferred into T lymphocytes: an approach to gene therapy against human immunodeficiency virus type 1 infection

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Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor

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A comparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes

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Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin

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12 December 2020

Identifiers

DOI

10.1007/S001090050039

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27 September 2017

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PubMed ID

8841950