Role of tyrosine kinases in lymphocyte activation: targets for drug intervention (Q41143249)

27 September 2017

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title

Role of tyrosine kinases in lymphocyte activation: targets for drug intervention (English)

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27 September 2017

J H Hanke

1

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27 September 2017

B A Pollok

series ordinal

2

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27 September 2017

P S Changelian

series ordinal

3

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27 September 2017

publication date

1 September 1995

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27 September 2017

published in

Inflammation Research

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27 September 2017

volume

44

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27 September 2017

issue

9

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27 September 2017

page(s)

357-371

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https://scigraph.springernature.com/pub.10.1007/bf01797862

27 September 2017

exact match

0 references

1 reference

https://api.crossref.org/works/10.1007%2FBF01797862

The role of the CD28 receptor during T cell responses to antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01797862

Signalling through CD28 T-cell activation pathway involves an inositol phospholipid-specific phospholipase C activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01797862

Structure and function of the B cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01797862

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01797862

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01797862

Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01797862

Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01797862

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01797862

The v-Src SH3 domain binds phosphatidylinositol 3'-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01797862

Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01797862

Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01797862

Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01797862

Tyrphostins. II. Heterocyclic and .alpha.-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases

21 January 2018

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12 December 2020

Constitutive activation of Src family kinases in mouse embryos that lack Csk.

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12 December 2020

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

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12 December 2020

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA.

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12 December 2020

Profound block in thymocyte development in mice lacking p56lck

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12 December 2020

Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation

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12 December 2020

Cytokines and growth factors signal through tyrosine phosphorylation of a family of related transcription factors

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12 December 2020

Cytokine signaling through nonreceptor protein tyrosine kinases

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12 December 2020

Functional and physical interaction of protein-tyrosine kinases Fyn and Csk in the T-cell signaling system

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12 December 2020

Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha

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12 December 2020

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

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12 December 2020

Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis

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12 December 2020

Synergistic interaction between complement receptor type 2 and membrane IgM on B lymphocytes

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12 December 2020

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

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12 December 2020

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

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12 December 2020

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.

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12 December 2020

Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase

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12 December 2020

Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family

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12 December 2020

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors

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12 December 2020

cyl encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src)

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12 December 2020

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

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12 December 2020

Genistein, a specific inhibitor of tyrosine-specific protein kinases

1 reference

12 December 2020

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

1 reference

12 December 2020

The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110

1 reference

12 December 2020

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

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12 December 2020

itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2

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12 December 2020

Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon.

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12 December 2020

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

1 reference

12 December 2020

The GTPase dynamin binds to and is activated by a subset of SH3 domains

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12 December 2020

Sequence requirements for induction of cytolysis by the T cell antigen/Fc receptor zeta chain

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12 December 2020

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

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12 December 2020

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

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12 December 2020

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

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12 December 2020

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

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12 December 2020

The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways

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12 December 2020

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor

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12 December 2020

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

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12 December 2020

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

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12 December 2020

Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta

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12 December 2020

Signal transduction by receptors with tyrosine kinase activity

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12 December 2020

Tyrosine kinase inhibition: an approach to drug development

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12 December 2020

CD28-B7 interactions in T-cell activation.

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12 December 2020

Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.

1 reference

12 December 2020

Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

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12 December 2020

The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity

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12 December 2020

B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia

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12 December 2020

A dominant-negative transgene defines a role for p56lck in thymopoiesis

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12 December 2020

Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway

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12 December 2020

Oncogenes and signal transduction

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12 December 2020

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

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12 December 2020

Two-step TCR zeta/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases

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12 December 2020

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn

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12 December 2020

Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg

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12 December 2020

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

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12 December 2020

Common subunits of cytokine receptors and the functional redundancy of cytokines

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12 December 2020

Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

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12 December 2020

Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII

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12 December 2020

Heterodimerization of the IL-2 receptor beta- and gamma-chain cytoplasmic domains is required for signalling

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12 December 2020

Inhibition of protein tyrosine phosphorylation prevents T-cell-mediated cytotoxicity

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12 December 2020

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor

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12 December 2020

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

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12 December 2020

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

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12 December 2020

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

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12 December 2020

Identification of an alternative CTLA-4 ligand costimulatory for T cell activation

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12 December 2020

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12 December 2020

A novel protein-tyrosine kinase, tec, is preferentially expressed in liver

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12 December 2020

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

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12 December 2020

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

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12 December 2020

SH3 domains direct cellular localization of signaling molecules

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12 December 2020

Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor

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12 December 2020

BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2

1 reference

12 December 2020

Effects of herbimycin derivatives on src oncogene function in relation to antitumor activity

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12 December 2020

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein

1 reference

12 December 2020

A protein tyrosine kinase in the interferon alpha/beta signaling pathway

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12 December 2020

Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association

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12 December 2020

The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation

1 reference

12 December 2020

CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes

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12 December 2020

Molecular approaches to analysis of X-linked immunodeficiencies

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12 December 2020

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway

1 reference

12 December 2020

p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation

1 reference

12 December 2020

Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction

1 reference

12 December 2020

The B-cell antigen receptor: structure and function of primary, secondary, tertiary and quaternary components

1 reference

12 December 2020

Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily

1 reference

12 December 2020

The hematopoietin receptor superfamily

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12 December 2020

CSK: a protein-tyrosine kinase involved in regulation of src family kinases

1 reference

12 December 2020

Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain

1 reference

12 December 2020

The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface

1 reference

12 December 2020

F2(Pmp)2-TAM zeta 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling

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12 December 2020

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

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12 December 2020

Peptide inhibitors of src SH3-SH2-phosphoprotein interactions

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12 December 2020

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C

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12 December 2020

The when and how of Src regulation

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12 December 2020

SH3--an abundant protein domain in search of a function

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12 December 2020

The IL-2/IL-2 receptor system: a current overview

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12 December 2020

Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk

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12 December 2020

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

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12 December 2020

Tyrosine phosphorylation of CD19 in pre-B and mature B cells

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12 December 2020

Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes

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12 December 2020

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

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12 December 2020

Peripheral T cells in mice lacking p56lck do not express significant antiviral effector functions

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12 December 2020

Signal transduction by the B cell antigen receptor and its coreceptors

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12 December 2020

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

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12 December 2020

T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

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12 December 2020

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion

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12 December 2020

'Bubble boy' paradox resolved

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12 December 2020

Molecular cloning and expression of chicken C-terminal Src kinase: lack of stable association with c-Src protein

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12 December 2020

T cell activation by clustered tyrosine kinases

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12 December 2020

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

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12 December 2020

The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

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12 December 2020

Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7

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12 December 2020

Ligation of CD28 receptor by B7 induces formation of D-3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation

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12 December 2020

Dissection of T cell antigen receptor signaling using protein tyrosine kinase inhibitors

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12 December 2020

The lymphocyte-specific tyrosine protein kinase p56lck

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12 December 2020

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

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12 December 2020

SH2 domains recognize specific phosphopeptide sequences

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12 December 2020

Regulation of basal tyrosine phosphorylation of the B cell antigen receptor complex by the protein tyrosine phosphatase, CD45

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12 December 2020

Expression of a novel form of the fyn proto-oncogene in hematopoietic cells

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12 December 2020

Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4

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12 December 2020

An interleukin-4-induced transcription factor: IL-4 Stat

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12 December 2020

Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19

1 reference

12 December 2020

A protein tyrosine kinase involved in regulation of pp60c-src function

1 reference

12 December 2020

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

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12 December 2020

ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

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12 December 2020

Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding

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12 December 2020

The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP

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12 December 2020

Signals for activation of CD8-dependent adhesion and costimulation in CTLs

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12 December 2020

Evidence that genistein, a protein-tyrosine kinase inhibitor, inhibits CD28 monoclonal-antibody-stimulated human T cell proliferation

1 reference

12 December 2020

Mutations in the SH3 domain of the src oncogene which decrease association of phosphatidylinositol 3'-kinase activity with pp60v-src and alter cellular morphology

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12 December 2020

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes

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12 December 2020

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

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12 December 2020

B70 antigen is a second ligand for CTLA-4 and CD28.

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12 December 2020

A hereditary immunodeficiency characterized by CD8+ T lymphocyte deficiency and impaired lymphocyte activation

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12 December 2020

CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line

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12 December 2020

JAK2, a third member of the JAK family of protein tyrosine kinases

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12 December 2020

The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules

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12 December 2020

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells

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12 December 2020

SH2 and SH3 domains: from structure to function

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12 December 2020

Signaling by the cytokine receptor superfamily: JAKs and STATs.

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12 December 2020

Specialized protein tyrosine kinase proto-oncogenes in hematopoietic cells

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12 December 2020

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

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12 December 2020

A specific inhibitor of the epidermal growth factor receptor tyrosine kinase

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12 December 2020

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling

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12 December 2020

Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo.

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12 December 2020

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules.

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12 December 2020

CD28-induced T cell activation. Evidence for a protein-tyrosine kinase signal transduction pathway

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12 December 2020

Point mutations define a mIgM transmembrane region motif that determines intersubunit signal transduction in the antigen receptor

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12 December 2020

Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation

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12 December 2020

Role of Bruton's tyrosine kinase in immunodeficiency

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12 December 2020

Identification and characterization of a novel tyrosine kinase from megakaryocytes

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12 December 2020

Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase

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12 December 2020

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12 December 2020

Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck

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12 December 2020

Signaling mechanisms through cytokine receptors that share signal transducing receptor components

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12 December 2020

Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts

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12 December 2020

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

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12 December 2020

Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells

1 reference

12 December 2020

MHC class II molecules deliver costimulatory signals in human T cells through a functional linkage with IL-2-receptors

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12 December 2020

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

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12 December 2020

Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells

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12 December 2020

Signalling through SH2 and SH3 domains

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12 December 2020

The conserved box 1 motif of cytokine receptors is required for association with JAK kinases

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12 December 2020

Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases

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12 December 2020

Activation of tyrosine kinase p60fyn following T cell antigen receptor cross-linking

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12 December 2020

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

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12 December 2020

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo

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12 December 2020

Antigen receptors on B lymphocytes

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12 December 2020

Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain

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12 December 2020

Allergy-associated I epsilon and Ec epsilon receptor II (CD23b) genes activated via binding of an interleukin-4-induced transcription factor to a novel responsive element

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12 December 2020

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

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12 December 2020

Role of the CD28 receptor in T-cell activation

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12 December 2020

A tyrosine-phosphorylated 70-kDa protein binds a photoaffinity analogue of ATP and associates with both the zeta chain and CD3 components of the activated T cell antigen receptor

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12 December 2020

The CD19 complex of B lymphocytes. Activation of phospholipase C by a protein tyrosine kinase-dependent pathway that can be enhanced by the membrane IgM complex

1 reference

12 December 2020

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness

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12 December 2020

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).

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12 December 2020

Identifiers

DOI

10.1007/BF01797862

1 reference

27 September 2017

1 reference