Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists (Q41154685)

27 September 2017

Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists (English)

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27 September 2017

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Turski L

1

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27 September 2017

Bressler K

2

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27 September 2017

Rettig KJ

3

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27 September 2017

Löschmann PA

4

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27 September 2017

Wachtel H

5

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27 September 2017

language of work or name

English

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publication date

1 January 1991

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27 September 2017

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27 September 2017

349

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27 September 2017

6308

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27 September 2017

414-418

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https://scigraph.springernature.com/pub.10.1038/349414a0

27 September 2017

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A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

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1-methyl-4-phenylpyridine is neurotoxic to the nigrostriatal dopamine pathway.

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Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+

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Magnesium gates glutamate-activated channels in mouse central neurones

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Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

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Synaptic activity mediates death of hypoxic neurons

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The biodisposition of MPP+ in mouse brain

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Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects.

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Uptake of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and the N-methyl-4-phenylpyridinium ion (MPP+) into fetal mouse brain through the placenta

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Uptake of a novel anticonvulsant compound, 2-amino-7-phosphono-[4,5-3H]heptanoic acid, into mouse brain

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Determination of the pharmacokinetics of 2-amino-7-phosphonoheptanoate in rat plasma and cerebrospinal fluid

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The histological effects of intracerebral injection or infusion of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and MPP+ (1-methyl-4-phenylpyridinium) in rat and mouse.

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Neurotoxic damage to the nigrostriatal system in rats following intranigral administration of MPDP+ and MPP+

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Ultrastructural alterations induced by 1-methyl-4-phenylpyridinium (MPP+) in canine substantia nigra and rat mesencephalon in vitro

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Alzheimer's disease, Parkinson's disease, and motoneurone disease: abiotrophic interaction between ageing and environment?

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Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin

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NEUROLOGICAL DISEASE IN BOXERS

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Beta-N-methylamino-L-alanine neurotoxicity: requirement for bicarbonate as a cofactor

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The role of excitatory amino acids and NMDA receptors in traumatic brain injury

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Anti-parkinsonian agents are phencyclidine agonists and N-methyl-aspartate antagonists

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Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

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The effect of deprenyl (selegiline) on the natural history of Parkinson's disease

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Two methods for selective silver impregnation of degenerating axons and their synaptic endings in the central nervous system.

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Identifiers

DOI

10.1038/349414A0

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Dimensions Publication ID

27 September 2017

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