The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1. (Q41166090)

27 September 2017

The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1. (English)

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27 September 2017

Yenush L

1

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27 September 2017

Makati KJ

2

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27 September 2017

Smith-Hall J

3

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27 September 2017

Ishibashi O

4

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27 September 2017

Myers MG Jr

5

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27 September 2017

White MF

6

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27 September 2017

language of work or name

English

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publication date

1 September 1996

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Journal of Biological Chemistry

27 September 2017

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27 September 2017

271

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27 September 2017

39

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27 September 2017

24300-24306

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Protein modules and signalling networks

27 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Role of IRS-2 in insulin and cytokine signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

New frontiers in insulin receptor substrate signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Role of IRS-1-GRB-2 complexes in insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

7 Preparation and use of anti-phosphotyrosine antibodies to study structure and function of insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

An alternative to SH2 domains for binding tyrosine-phosphorylated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

A phosphotyrosine interaction domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

G beta gamma interactions with PH domains and Ras-MAPK signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

Signal transduction. Just another signalling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.39.24300

21 January 2018

Identifiers

DOI

10.1074/JBC.271.39.24300

1 reference

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Fatcat

https://api.fatcat.wiki/v0/release/bglzm4d2gvc5nenehdqmtxgrlq

mapped directly with Wikidata item

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https://api.fatcat.wiki/v0/release/bglzm4d2gvc5nenehdqmtxgrlq