Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase (Q41174456)

27 September 2017

title

Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase (English)

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27 September 2017

R Rottapel

7

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author name string

N Beslu

1

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27 September 2017

J LaRose

2

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27 September 2017

N Casteran

3

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27 September 2017

D Birnbaum

4

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27 September 2017

E Lecocq

5

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27 September 2017

P Dubreuil

6

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27 September 2017

language of work or name

English

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publication date

1 August 1996

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Journal of Biological Chemistry

27 September 2017

published in

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27 September 2017

volume

271

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27 September 2017

issue

33

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27 September 2017

page(s)

20075-20081

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Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors

27 September 2017

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The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors

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Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

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Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells

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Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation

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Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

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A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine

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Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor

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GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit

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Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

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PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

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Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

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Association of p21ras with phosphatidylinositol 3-kinase

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

21 January 2018

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Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

21 January 2018

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Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

21 January 2018

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SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors

21 January 2018

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The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice.

21 January 2018

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Phosphatidylinositol kinase activity associates with viral p60src protein

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Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation

21 January 2018

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Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells

21 January 2018

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Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction

21 January 2018

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The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

21 January 2018

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Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase

21 January 2018

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A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor

21 January 2018

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Tyrosine 569 in the c-Fms juxtamembrane domain is essential for kinase activity and macrophage colony-stimulating factor-dependent internalization

21 January 2018

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

21 January 2018

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Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

21 January 2018

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Multiple Cytokines Stimulate the Binding of a Common 145-Kilodalton Protein to Shc at the Grb2 Recognition Site of Shc

21 January 2018

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Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells

21 January 2018

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An alternative to SH2 domains for binding tyrosine-phosphorylated proteins

21 January 2018

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Src homology region 2 domains direct protein-protein interactions in signal transduction

21 January 2018

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Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1

21 January 2018

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Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains

21 January 2018

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A protein that is highly related to GTPase-activating protein-associated p62 complexes with phospholipase C gamma

21 January 2018

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P62 association with RNA is regulated by tyrosine phosphorylation.

21 January 2018

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A target for Src in mitosis.

21 January 2018

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An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis

21 January 2018

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GTPase-activating protein interactions with the viral and cellular Src kinases

21 January 2018

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Binding of GAP to activated PDGF receptors

21 January 2018

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PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

21 January 2018

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Oncogenes and signal transduction

21 January 2018

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Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling

21 January 2018

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A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits

21 January 2018

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Signal transduction by receptors with tyrosine kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.33.20075

Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking

21 January 2018

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Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.

21 January 2018

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Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.271.33.20075

SH2 domains recognize specific phosphopeptide sequences

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.271.33.20075

Modification of the 85-kilodalton subunit of phosphatidylinositol-3 kinase in platelet-derived growth factor-stimulated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.33.20075

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.271.33.20075

Regulation of chemotaxis by the platelet-derived growth factor receptor-beta

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.271.33.20075

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.271.33.20075

The v-Src SH3 domain binds phosphatidylinositol 3'-kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.271.33.20075

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells

21 January 2018

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Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity

21 January 2018

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A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole

21 January 2018

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

21 January 2018

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p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity

21 January 2018

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The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

21 January 2018

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Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7

21 January 2018

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A safe packaging line for gene transfer: separating viral genes on two different plasmids

21 January 2018

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24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1128/JVI.62.4.1120-1124.1988

Identifiers

DOI

10.1074/JBC.271.33.20075

1 reference

27 September 2017

1 reference