Pediatric drug development: a perspective from the Cancer Therapy Evaluation Program (CTEP) of the National Cancer Institute (NCI). (Q41175743)

27 September 2017

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title

Pediatric drug development: a perspective from the Cancer Therapy Evaluation Program (CTEP) of the National Cancer Institute (NCI). (English)

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27 September 2017

M Smith

1

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27 September 2017

P T Ho

series ordinal

2

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27 September 2017

publication date

1 January 1996

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Investigational New Drugs

27 September 2017

published in

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27 September 2017

volume

14

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27 September 2017

issue

1

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27 September 2017

page(s)

11-22

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Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate

27 September 2017

cites work

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12 December 2020

Studies on the differentiation inducers of myeloid leukemic cells. III. Spicamycin, a new inducer of differentiation of HL-60 human promyelocytic leukemia cells

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12 December 2020

Inhibition of microtubules and cell cycle arrest by a new 1-deaza-7,8-dihydropteridine antitumor drug, CI 980, and by its chiral isomer, NSC 613863.

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12 December 2020

Phase I evaluation of all-trans-retinoic acid in adults with solid tumors

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12 December 2020

Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase I Committee

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12 December 2020

Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation

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12 December 2020

Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts

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12 December 2020

Relation of preclinical toxicology to findings in early clinical trials

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12 December 2020

Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide

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12 December 2020

Biotherapy for xenografted human central nervous system leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin

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12 December 2020

Establishment of a human t(4;11) leukemia in severe combined immunodeficient mice and successful treatment using anti-CD19 (B43)-pokeweed antiviral protein immunotoxin

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12 December 2020

Saturable pharmacokinetics and paclitaxel pharmacodynamics in children with solid tumors

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12 December 2020

Phase II testing of melphalan in children with newly diagnosed rhabdomyosarcoma: a model for anticancer drug development

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12 December 2020

Potent and specific inhibitors of protein kinase C of microbial origin

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12 December 2020

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

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12 December 2020

Development and characterization of pediatric osteosarcoma xenografts

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12 December 2020

Induction of differentiation in neuro-2A cells by the monoterpene perillyl alcohol

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12 December 2020

Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhi

1 reference

12 December 2020

Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity

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12 December 2020

Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors

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12 December 2020

Effects of CPT-11 (a unique DNA topoisomerase I inhibitor) on a highly malignant xeno-transplanted neuroblastoma

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12 December 2020

The conduct of phase I-II clinical trials in children with cancer

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12 December 2020

A comparison of two phase I trial designs.

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12 December 2020

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

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12 December 2020

Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents

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12 December 2020

Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihydro-3-[(N-methylanilino)methyl]-pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928).

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12 December 2020

Pharmacologically guided phase I clinical trials based upon preclinical drug development

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12 December 2020

Variability in the oral bioavailability of all-trans-retinoic acid

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12 December 2020

A phase I trial of bryostatin 1 in patients with advanced malignancy using a 24 hour intravenous infusion.

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12 December 2020

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids

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12 December 2020

Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene

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12 December 2020

A phase I study of intravenous bryostatin 1 in patients with advanced cancer

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12 December 2020

Phase I trial of paclitaxel in children with refractory solid tumors: a Pediatric Oncology Group Study.

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12 December 2020

Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue

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12 December 2020

Tretinoin toxicity in children with acute promyelocytic leukaemia

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12 December 2020

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

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12 December 2020

Scheduling of vincristine: drug accumulation and response of xenografts of childhood rhabdomyosarcoma determined by frequency of administration

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12 December 2020

Phenylacetate synergizes with retinoic acid in inducing the differentiation of human neuroblastoma cells

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12 December 2020

Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275

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12 December 2020

Tributyrin: a prodrug of butyric acid for potential clinical application in differentiation therapy.

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12 December 2020

Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation

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12 December 2020

Paclitaxel (Taxol) and docetaxel (Taxotere): not simply two of a kind

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12 December 2020

Antitumor activity of a spicamycin derivative, KRN5500, and its active metabolite in tumor cells

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12 December 2020

Tolerance to antineoplastic agents in children and adults

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12 December 2020

Protein kinase C and lipid signaling for sustained cellular responses

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12 December 2020

Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells

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12 December 2020

Receptor protein-tyrosine kinases and their signal transduction pathways

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12 December 2020

Effective immunochemotherapy of CALLA+C mu+ human pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19) pokeweed antiviral protein immunotoxin plus cyclophosphamide

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12 December 2020

Experimental chemotherapy of human medulloblastoma with classical alkylators

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12 December 2020

Mechanism of action of taxol

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12 December 2020

Phase I and pharmacokinetic evaluation of all-trans-retinoic acid in pediatric patients with cancer

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12 December 2020

Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases

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12 December 2020

Production and biological activity of rebeccamycin, a novel antitumor agent.

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12 December 2020

Role of the cyclin-dependent kinase inhibitors in the development of cancer.

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12 December 2020

Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts

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12 December 2020

Physiologic changes during growth and development

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12 December 2020

Childhood rhabdomyosarcoma xenografts: responses to DNA-interacting agents and agents used in current clinical therapy.

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12 December 2020

Identifiers

DOI

10.1007/BF00173678

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Dimensions Publication ID

27 September 2017

1049611123

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