The PKC inhibitor AEB071 may be a therapeutic option for psoriasis. (Q41189960)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18688284%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

The PKC inhibitor AEB071 may be a therapeutic option for psoriasis (English)

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11 January 2020

10

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11 January 2020

Christopher Griffiths

18

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11 January 2020

19

Georg Stingl

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11 January 2020

8

Tamara Kopp

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11 January 2020

1

Hans Skvara

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11 January 2020

5

Josef G Meingassner

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11 January 2020

author name string

Markus Dawid

2

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11 January 2020

Elise Kleyn

3

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11 January 2020

Barbara Wolff

4

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11 January 2020

Hilary Knight

6

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11 January 2020

Thomas Dumortier

7

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11 January 2020

Nasanin Fallahi

9

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11 January 2020

Christoph Burkhart

11

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11 January 2020

Olivier Grenet

12

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11 January 2020

Juergen Wagner

13

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11 January 2020

Youssef Hijazi

14

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11 January 2020

Randall E Morris

15

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11 January 2020

Claire McGeown

16

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11 January 2020

Christiane Rordorf

17

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11 January 2020

Thomas Jung

20

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11 January 2020

language of work or name

English

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publication date

1 September 2008

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Journal of Clinical Investigation

11 January 2020

published in

1 reference

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11 January 2020

volume

118

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11 January 2020

issue

9

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11 January 2020

page(s)

3151-3159

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PKC inhibition and diabetic microvascular complications

11 January 2020

cites work

1 reference

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28 September 2017

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Protein kinase C family: on the crossroads of cell signaling in skin and tumor epithelium

28 September 2017

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Pathogenesis and clinical features of psoriasis

28 September 2017

1 reference

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Pathogenesis and therapy of psoriasis

28 September 2017

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Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

28 September 2017

1 reference

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The evaluation of psoriasis therapy with biologics leads to a revision of the current view of the pathogenesis of this disorder

28 September 2017

1 reference

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Selective function of PKC-theta in T cells

28 September 2017

1 reference

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CXCR2 ligands and G-CSF mediate PKCalpha-induced intraepidermal inflammation

28 September 2017

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Preclinical and clinical development of novel agents that target the protein kinase C family

28 September 2017

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Infliximab for the treatment of psoriasis

28 September 2017

1 reference

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PKCtheta: A potential therapeutic target for T-cell-mediated diseases.

28 September 2017

1 reference

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Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice

28 September 2017

1 reference

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The IL-12 family member p40 chain as a master switch and novel therapeutic target in psoriasis

28 September 2017

1 reference

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Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model

28 September 2017

1 reference

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Protein kinase C and beyond

28 September 2017

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Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities

28 September 2017

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Protein kinase C family functions in B-cell activation

28 September 2017

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Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha

28 September 2017

1 reference

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Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris

28 September 2017

1 reference

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Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways

28 September 2017

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Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

28 September 2017

1 reference

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Vitamin D analogs: mechanism of action and therapeutic applications

28 September 2017

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Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial

28 September 2017

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Novel retinoids with receptor selectivity and functional selectivity

28 September 2017

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CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris

28 September 2017

1 reference

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Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.

28 September 2017

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Selective modulation of protein kinase C-theta during T-cell activation

28 September 2017

1 reference

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Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis

28 September 2017

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Severe Psoriasis – Oral Therapy with a New Retinoid

28 September 2017

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Protein kinase C epsilon, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3.

28 September 2017

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T cell expressed PKCtheta demonstrates cell-type selective function

14 June 2018

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Remission of psoriatic lesions with muromonab-CD3 (orthoclone OKT3) treatment

14 June 2018

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The tumour necrosis factor-alpha inhibitor adalimumab rapidly reverses the decrease in epidermal Langerhans cell density in psoriatic plaques.

14 June 2018

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Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo

19 August 2018

1 reference

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Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis

19 August 2018

1 reference

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Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes.

19 August 2018

1 reference

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Immunopathologic features of allergic contact dermatitis in humans: participation of plasmacytoid dendritic cells in the pathogenesis of the disease?

19 August 2018

1 reference

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Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial

4 November 2018

1 reference

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Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

4 November 2018

1 reference

12 December 2020

Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis

1 reference

12 December 2020

A Phase I Study Evaluating the Safety, Pharmacokinetics, and Clinical Response of a Human IL-12 p40 Antibody in Subjects with Plaque Psoriasis

1 reference

12 December 2020

Defective IgG2a/2b class switching in PKC alpha-/- mice

1 reference

12 December 2020

Successful in vivo blockade of CD25 (high-affinity interleukin 2 receptor) on T cells by administration of humanized anti-Tac antibody to patients with psoriasis

1 reference

12 December 2020

Protein kinase Cδ controls self-antigen-induced B-cell tolerance

1 reference

12 December 2020

Identification of Cellular Pathways of "Type 1," Th17 T Cells, and TNF- and Inducible Nitric Oxide Synthase-Producing Dendritic Cells in Autoimmune Inflammation through Pharmacogenomic Study of Cyclosporine A in Psoriasis

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI35636

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18688284%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18688284%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

PubMed publication ID

18688284

1 reference