Clinical pharmacokinetics and metabolism of chloroquine. Focus on recent advancements (Q41192707)

28 September 2017

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title

Clinical pharmacokinetics and metabolism of chloroquine. Focus on recent advancements (English)

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28 September 2017

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J Ducharme

1

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PubMed ID

8896943

28 September 2017

R Farinotti

series ordinal

2

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28 September 2017

1 October 1996

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Clinical Pharmacokinetics

28 September 2017

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28 September 2017

31

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28 September 2017

4

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28 September 2017

257-274

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https://scigraph.springernature.com/pub.10.2165/00003088-199631040-00003

28 September 2017

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The mode of action of chloroquine. Non-weak base properties of 4-aminoquinolines and antimalarial effects on strains of Plasmodium

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Drug interaction of chloroquine with ciclosporin

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Determination of chloroquine and its desethyl metabolite in plasma, red blood cells and urine by liquid chromatography

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12 December 2020

Stereoselectivity in the disposition of chloroquine and desethylchloroquine in rabbits

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The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects

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The effect of streptozotocin-induced diabetes on the in vivo acetylation capacity and the in vitro blood N-acetyltransferase activity of the adult male Sprague-Dawley rat

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Plasmodium falciparum: modulation by calcium antagonists of resistance to chloroquine, desethylchloroquine, quinine, and quinidine in vitro

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The drug interaction potential of ranitidine: an update

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Beyond chloroquine: implications of drug resistance for evaluating malaria therapy efficacy and treatment policy in Africa

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Protein binding of chloroquine enantiomers and desethylchloroquine

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Chloroquine excretion following malaria prophylaxis

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12 December 2020

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

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12 December 2020

Inhibition of metoprolol metabolism by chloroquine and other antimalarial drugs

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12 December 2020

CHLOROQUINE IN NAIL CLIPPINGS

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12 December 2020

Kinetics of the uptake and elimination of chloroquine in children with malaria

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12 December 2020

Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine

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12 December 2020

Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily

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12 December 2020

In vitro activity of chloroquine, the two enantiomers of chloroquine, desethylchloroquine and pyronaridine against Plasmodium falciparum.

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12 December 2020

Possible chloroquine-induced modification of N-acetylation of isoniazid and sulphadimidine in the rat.

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12 December 2020

Chloroquine elimination in humans: effect of low-dose cimetidine

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12 December 2020

The prevention of antimalarial drug resistance

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12 December 2020

On the question of dose-dependent chloroquine elimination of a single oral dose

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12 December 2020

Reversal of chloroquine resistance in Plasmodium falciparum by verapamil

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12 December 2020

Quinine disposition during malaria and during induced fever

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12 December 2020

Disposition of the enantiomers of hydroxychloroquine in patients with rheumatoid arthritis following multiple doses of the racemate

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12 December 2020

Parenteral chloroquine for treating falciparum malaria

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12 December 2020

On the question of interindividual variations in chloroquine concentrations

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12 December 2020

Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19

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The potential role of lysosomes in tissue distribution of weak bases

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Metoprolol and debrisoquin metabolism in Nigerians: lack of evidence for polymorphic oxidation

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Histamine N-methyl transferase: inhibition by drugs

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Studies on the mechanism of drug-binding to melanin

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Clathrin-coated vesicles: Isolation, dissociation and factor-dependent reassociation of clathrin baskets

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12 December 2020

The distribution of chloroquine in man after fatal poisoning

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12 December 2020

The metabolism of chloroquine in man during and after repeated oral dosage

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12 December 2020

Identification of distinct accumulation sites of 4-aminoquinoline in chloroquine sensitive and resistant Plasmodium berghei strains.

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12 December 2020

Placental and milk transfer of chloroquine in humans.

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12 December 2020

Excretion of chloroquine, dapsone and pyrimethamine in human milk

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12 December 2020

Drug metabolism by rat and human hepatic microsomes in response to interaction with H2-receptor antagonists

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12 December 2020

Distribution of the enantiomers of hydroxychloroquine and its metabolites in ocular tissues of the rabbit after oral administration of racemic-hydroxychloroquine

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12 December 2020

Enantioselective analysis of chloroquine and desethylchloroquine after oral administration of racemic chloroquine

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12 December 2020

Enhancement of drug susceptibility in Plasmodium falciparum in vitro and Plasmodium berghei in vivo by mixed-function oxidase inhibitors

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12 December 2020

Distribution of chloroquine and desethylchloroquine in blood, plasma and erythrocytes of healthy subjects and malaria patients. Assay using HPLC

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12 December 2020

Characterization of chloroquine plasma protein binding in man.

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12 December 2020

Apparent dose-dependence of chloroquine pharmacokinetics due to limited assay sensitivity and short sampling times

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12 December 2020

Antimalarial activity of the optical isomers of chloroquine diphosphate

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12 December 2020

Chloroquine transfer to milk. A case

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12 December 2020

Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications

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12 December 2020

Excretion of drugs in human milk

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12 December 2020

The pharmacokinetics of three multiple dose regimens of chloroquine: implications for malaria chemoprophylaxis

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12 December 2020

Disposition of sulfamethazine and N-acetylsulfamethazine in the rat

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12 December 2020

Single dose disposition of chloroquine in kwashiorkor and normal children--evidence for decreased absorption in kwashiorkor

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12 December 2020

A predictive model for substrates of cytochrome P450-debrisoquine (2D6)

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12 December 2020

Differential inhibition of individual human liver cytochromes P-450 by cimetidine

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12 December 2020

Plasma chloroquine and desethylchloroquine concentrations in children during and after chloroquine treatment for malaria

1 reference

12 December 2020

The effects of cyclosporine on the pharmacokinetics of doxorubicin in patients with small cell lung cancer.

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12 December 2020

Enantioselective disposition of hydroxychloroquine after a single oral dose of the racemate to healthy subjects

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12 December 2020

PITFALLS IN THE MEASUREMENT OF CHLOROQUINE CONCENTRATIONS

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12 December 2020

The Binding of Chloroquine to Normal and Kwashiorkor Serum *

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12 December 2020

Distribution of chloroquine and its metabolite desethyl-chloroquine in human blood cells and its implication for the quantitative determination of these compounds in serum and plasma

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12 December 2020

Multiple-drug resistance in human cancer

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12 December 2020

Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine

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12 December 2020

Effects of chloroquine and primaquine on rat liver cytosolic N-acetyltransferase activity

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12 December 2020

Tissue and blood concentrations of chloroquine following chronic administration in the rat

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12 December 2020

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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12 December 2020

Chloroquine treatment of severe malaria in children. Pharmacokinetics, toxicity, and new dosage recommendations

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12 December 2020

Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes

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12 December 2020

Pharmacologic actions of 4-aminoquinoline compounds

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12 December 2020

Alteration of cytochrome P-450 by prolonged administration of imipramine and/or lithium to rats

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12 December 2020

Antimalarials increase vesicle pH in Plasmodium falciparum

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12 December 2020

The urinary excretion of chloroquine in different ethnic groups

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12 December 2020

Comparison of the pharmacokinetics of chloroquine after single intravenous and intramuscular administration in healthy Africans

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12 December 2020

Safety of chloroquine in chemosuppression of malaria during pregnancy

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12 December 2020

Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect

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12 December 2020

Steady state disposition of chloroquine in patients with rheumatoid disease

1 reference

12 December 2020

Chloroquine levels in blood during chronic treatment of patients with rheumatoid arthritis

1 reference

12 December 2020

Kinetics and thermodynamics of chloroquine and hydroxychloroquine transport across the human erythrocyte membrane

1 reference

12 December 2020

Chloroquine serum concentration and side effects: Evidence for dose-dependent kinetics

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12 December 2020

Chloroquine kinetics in the undernourished

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12 December 2020

Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.

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12 December 2020

Quinine pharmacokinetics and toxicity in cerebral and uncomplicated Falciparum malaria

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12 December 2020

Antimalarials in rheumatology: efficacy and safety

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12 December 2020

Tissue distribution of subcutaneously administered chloroquine in the rat

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12 December 2020

Inhibitory effects of antiparasitic drugs on cytochrome P450 2D6.

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12 December 2020

The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450

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12 December 2020

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

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12 December 2020

Chloroquine enantiomers. Activity against P. vinckei and binding on DNA (author's transl)

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12 December 2020

In vitro assessment of the antimalarial activity of chloroquine and its major metabolites

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12 December 2020

Significant reduction in chloroquine bioavailability following coadministration with the Sudanese beverages Aradaib, Karkadi and Lemon

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12 December 2020

An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systems

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12 December 2020

Uptake of chloroquine and hydroxychloroquine by human blood leucocytes in vitro: relation to cellular concentrations during antirheumatic therapy

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12 December 2020

Further support for changes in chloroquine disposition and metabolism between a low and a high dose

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12 December 2020

Susceptibility of human malaria parasites to chloroquine is pH dependent

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12 December 2020

Characteristics of chloroquine binding to glass and plastic

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12 December 2020

Stereoselective inhibition by chloroquine of histamine N-methyltransferase in the human liver and brain

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12 December 2020

Complete heart block in chronic chloroquine poisoning

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12 December 2020

Whole-blood single-dose kinetics of chloroquine and desethylchloroquine in Africans

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12 December 2020

Stereoselective pharmacokinetic properties of chloroquine and de-ethyl-chloroquine in humans.

1 reference

12 December 2020

Suppression of the chloroquine resistance of Plasmodium berghei by treatment of infected mice with a microsomal monooxygenase inhibitor

1 reference

12 December 2020

Sensitive method for the determination of chloroquine and its metabolite desethyl-chloroquine in human plasma and urine by high-performance liquid chromatography

1 reference

12 December 2020

Quercetin, an in vitro inhibitor of CYP3A, does not contribute to the interaction between nifedipine and grapefruit juice

1 reference

12 December 2020

Lack of effect of chloroquine on the debrisoquine (CYP2D6 and S-mephenytoin (CYP2C19) hydroxylation phenotypes

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12 December 2020

Disposition of chloroquine in man after single intravenous and oral doses

1 reference

12 December 2020

The quinine-haemin interaction and its relationship to antimalarial activity

1 reference

12 December 2020

Studies of the metabolism of some compounds of the 4-amino-7-chloroquinoline series.

1 reference

12 December 2020

Plasma protein binding of the enantiomers of hydroxychloroquine and metabolites

1 reference

12 December 2020

Effect of food on bioavailability of chloroquine

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12 December 2020

Improved fluorimetrie assay of chloroquine in biological samples

1 reference

12 December 2020

Pharmacokinetics of chloroquine and some of its metabolites in healthy volunteers: a single dose study

1 reference

12 December 2020

A study of the debrisoquine hydroxylation polymorphism in a Nigerian population

1 reference

12 December 2020

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1 reference

12 December 2020

Hematologic disposition of hydroxychloroquine enantiomers

1 reference

12 December 2020

Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-demethylation and 4-hydroxylation

1 reference

12 December 2020

Recent developments in the understanding of the pharmacokinetics and mechanism of action of chloroquine

1 reference

12 December 2020

Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target

1 reference

12 December 2020

Inhibition and induction of cytochrome P450 isozymes after repetitive administration of imipramine in rats.

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12 December 2020

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12 December 2020

Pharmacokinetics of chloroquine in Thais: plasma and red-cell concentrations following an intravenous infusion to healthy subjects and patients with Plasmodium vivax malaria

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12 December 2020

The pharmacokinetics of chloroquine in healthy Thai subjects and patients with Plasmodium vivax malaria.

1 reference

12 December 2020

Effect of ranitidine on chloroquine disposition

1 reference

12 December 2020

Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs.

1 reference

12 December 2020

Clinical pharmacokinetics of antimalarial drugs

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12 December 2020

Placental transfer of chloroquine in pregnant rabbits

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12 December 2020

Excretion of chloroquine and desethylchloroquine in human milk

1 reference

12 December 2020

Pregnancy outcome following first trimester exposure to chloroquine

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12 December 2020

Alpha 1-acid glycoprotein (orosomucoid) and plasma protein binding of quinine in falciparum malaria

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12 December 2020

Effects of chloroquine and didesethylchloroquine on rabbit myocardium and mitochondria

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12 December 2020

In vitro study of the transplacental passage of chloroquine sulfate

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12 December 2020

10.2165/00003088-199631040-00003

Identifiers

DOI

1 reference

PubMed ID

8896943

Dimensions Publication ID

28 September 2017

0 references

1 reference

PubMed ID

8896943