The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice (Q41245074)

28 September 2017

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title

The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice (English)

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28 September 2017

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C D Funk

1

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28 September 2017

1 November 1996

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Biochimica et Biophysica Acta

28 September 2017

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28 September 2017

1304

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28 September 2017

65-84

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28 September 2017

1

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28 September 2017

Crystalline lipoxidase.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

The three-dimensional structure of an arachidonic acid 15-lipoxygenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Molecular cloning and primary structure of human 15-lipoxygenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Mammalian lipoxygenases: molecular structures and functions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Two immunologically and catalytically distinct arachidonate 12-lipoxygenases of bovine platelets and leukocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Demonstration of a 12-lipoxygenase activity in bovine polymorphonuclear leukocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Genomic and cDNA cloning of a novel mouse lipoxygenase gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Functional expression and cellular localization of a mouse epidermal lipoxygenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Identification of 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE) as a major metabolite of arachidonic acid in human lung

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Generation of the arachidonic acid metabolite 8-HETE by extracts of mouse skin treated with phorbol ester in vivo; identification by 1H-n.m.r. and GC-MS spectroscopy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

The structure and function of lipoxygenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Lipoxygenases: structural principles and spectroscopy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Arachidonate 15-lipoxygenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

12-lipoxygenases and 12(S)-HETE: role in cancer metastasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Prostaglandin H synthase and lipoxygenase gene families in the epithelial cell barrier

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

"Enzymatic" lipid peroxidation: reactions of mammalian lipoxygenases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Regio- and stereochemistry of the dioxygenation reaction catalyzed by (S)-type lipoxygenases or by the cyclooxygenase activity of prostaglandin H synthases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Molecular cloning and expression of human arachidonate 12-lipoxygenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Arachidonate 12-lipoxygenase of rat pineal glands: catalytic properties and primary structure deduced from its cDNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Molecular cloning of a 12-lipoxygenase cDNA from rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Cloning and characterization of a murine macrophage lipoxygenase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

The complete sequence of the rabbit erythroid cell-specific 15-lipoxygenase mRNA: comparison of the predicted amino acid sequence of the erythrocyte lipoxygenase with other lipoxygenases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

The promoter structure and complete sequence of the gene encoding the rabbit erythroid cell-specific 15-lipoxygenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

The transcriptional regulation of human arachidonate 12-lipoxygenase gene by NF kappa B/Rel

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Tissue-specific regulation of the rabbit 15-lipoxygenase gene in erythroid cells by a transcriptional silencer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Cloning of the guinea pig 5-lipoxygenase gene and nucleotide sequence of its promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Regulation of 5-lipoxygenase and 5-lipoxygenase-activating protein expression in HL-60 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Deficiency of platelet lipoxygenase activity in myeloproliferative disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Decreased messenger RNA of arachidonate 12-lipoxygenase in platelets of patients with myeloproliferative disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Localization of arachidonate 12-lipoxygenase in canine brain tissues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Arachidonate 12-lipoxygenase is localized in neurons, glial cells, and endothelial cells of the canine brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Ribozyme-mediated inhibition of expression of leukocyte-type 12-lipoxygenase in porcine aortic vascular smooth muscle cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Interactions of 5-lipoxygenase with membranes: studies on the association of soluble enzyme with membranes and alterations in enzyme activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

5-lipoxygenase-activating protein is an arachidonate binding protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Tyrosine kinase activity modulates catalysis and translocation of cellular 5-lipoxygenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Fibronectin-induced cell spreading and down-regulation of 12-lipoxygenase expression in megakaryocytic DAMI cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Activity and protein distribution of 12-lipoxygenase in HEL cells: induction of membrane-association by phorbol ester TPA, modulation of activity by glutathione and 13-HPODE, and Ca(2+)-dependent translocation to membranes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

12-Lipoxygenase in Lewis lung carcinoma cells: molecular identity, intracellular distribution of activity and protein, and Ca(2+)-dependent translocation from cytosol to membranes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Calcium promotes membrane association of reticulocyte 15-lipoxygenase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Altering genes in animals by gene targeting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Targeted gene disruption by homologous recombination. Toward an understanding of specific blood cell functions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Scoring a technical knockout in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Altered inflammatory responses in leukotriene-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Stimulation of human myelopoiesis by leukotriene B4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Leukotriene B4 in the immune system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Augmentation of human natural cytotoxic cell activity by leukotriene B4 mediated by enhanced effector-target cell binding and increased lytic efficiency.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Pulmonary responses to bronchoconstrictor agonists in the mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Sorting out the cytokines of asthma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Nonimmunological production of leukotrienes induced by platelet-activating factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

The Lipoxygenase of Reticulocytes. Purification, Characterization and Biological Dynamics of the Lipoxygenase; Its Identity with the Respiratory Inhibitors of the Reticulocyte

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

A possible role for 15-lipoxygenase in atherogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Enhanced levels of lipoperoxides in low density lipoprotein incubated with murine fibroblast expressing high levels of human 15-lipoxygenase

7 January 2021

1 reference

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Specific action of the lipoxygenase pathway in mediating angiotensin II-induced aldosterone synthesis in isolated adrenal glomerulosa cells

7 January 2021

1 reference

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Subcellular localization of 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid binding sites in Lewis lung carcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

The RXR heterodimers and orphan receptors

7 January 2021

1 reference

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Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

7 January 2021

1 reference

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Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

Molecular biology in the eicosanoid field

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2896%2900107-5

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0005-2760(96)00107-5

1 reference

28 September 2017

1 reference

PubMed ID

8944751