Review of theoretical passive drug absorption models: historical background, recent developments and limitations (Q41279377)

29 September 2017

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title

Review of theoretical passive drug absorption models: historical background, recent developments and limitations (English)

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29 September 2017

G Camenisch

1

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29 September 2017

G Folkers

series ordinal

2

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29 September 2017

H van de Waterbeemd

series ordinal

3

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29 September 2017

publication date

1 November 1996

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Pharmaceutica acta Helvetiae

29 September 2017

published in

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29 September 2017

volume

71

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29 September 2017

issue

5

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29 September 2017

page(s)

309-327

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The Factors that Influence Skin Penetration of Solutes*

29 September 2017

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The influence of alkyl substitution in acids on their performance in the buccal absorption test

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Acidification in the rat proximal jejunum

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A new method for estimating dermal absorption from chemical exposure: 2. Effect of molecular weight and octanol-water partitioning.

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The Partition of Organic Compounds Between Higher Alcohols and Water

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Drug Absorption IV: Influence of pH on Absorption Kinetics of Weakly Acidic Drugs

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DRUG PARTITIONING. II. IN VITRO MODEL FOR DRUG ABSORPTION

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Methods for Quantifying the transport of drugs across brain barrier systems

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Correlation and Prediction of Mass Transport across Membranes I: Influence of Alkyl Chain Length on Flux-Determining Properties of Barrier and Diffusant

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Mass transport Phenomena and Models: Theoretical Concepts

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Hydrogen-bonding parameter and its significance in quantitative structure--activity studies

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A Novel Method for Measuring Membrane-Water Partition Coefficients of Hydrophobic Organic Chemicals: Comparison with 1-Octanol–Water Partitioning

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Rate-limiting barriers to intestinal drug absorption: a review

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Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa

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Theoretical Model Studies of Drug Absorption and Transport in the GI Tract III

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7 January 2021

Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers

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7 January 2021

Absorption and Excretion of Drugs. XXV. On the Mechanism of Rectal Absorption of Sulfonamides

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7 January 2021

Absorption and Excretion of Drugs. XXX. Absorption of Barbituric Acid Derivatives from Rat Stomach

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7 January 2021

Absorption and Excretion of Drugs. XXXII. Absorption of Barbituric Acid Derivatives from Rat Small Intestine

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Absorption and Excretion of Drugs. XXXIII. The Correlation between the Absorption of Barbituric Acid Derivatives from the Rat Small Intestine and Their Binding to the Mucosa

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7 January 2021

ABSORPTION AND EXCRETION OF DRUGS. XIX. SOME PHARMACOKINETIC ASPECTS OF ABSORPTION AND EXCRETION OF SULFONAMIDES. (1). ABSORPTION FROM RAT STOMACH

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ABSORPTION AND EXCRETION OF DRUGS. XX. SOME PHARMACOKINETIC ASPECTS OF ABSORPTION AND EXCRETION OF SULFONAMIDES. (2). ABSORPTION FROM RAT SMALL INTESTINE

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7 January 2021

Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation?

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7 January 2021

Calculating log Poct from structures

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7 January 2021

Partition coefficients and their uses

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7 January 2021

Factors affecting gastrointestinal absorption of drugs

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7 January 2021

QSAR analysis of skin permeability of various drugs in man as compared to in vivo and in vitro studies in rodents

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7 January 2021

A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry

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7 January 2021

Theoretical model-based equations for the linear free energy relationships of the biological activity of ionizable substances. 1. Equilibrium-controlled potency

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Transport mechanism of ceftibuten, a dianionic cephem, in rat renal brush-border membrane

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7 January 2021

Theorie der Reaktionsgeschwindigkeit in heterogenen Systemen

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7 January 2021

Transport of steroid hormones through the rat blood-brain barrier. Primary role of albumin-bound hormone

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7 January 2021

Intestinal absorption-partition relationships: A tentative functional nonlinear model

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7 January 2021

Predicting skin permeability

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7 January 2021

The influence of molecular volume and hydrogen-bonding on peptide transport across epithelial membranes

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7 January 2021

A predictive algorithm for skin permeability: the effects of molecular size and hydrogen bond activity

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7 January 2021

Use of distribution coefficients in quantitative structure-activity relations

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7 January 2021

Analysis of Permeability Data for the Case of Parallel Diffusion Pathways

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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Selection of a Reference Partitioning System for Drug Design Work

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7 January 2021

Diffusional model for transport rate studies across membranes

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7 January 2021

In vitro model for transport of solutes in three-phase system. I. Theoretical principles

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

The relationship between permeant size and permeability in lipid bilayer membranes

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7 January 2021

Transport of alkyl Homologs Across Synthetic and Biological Membranes: A new Model for Chain Length-Activity Relationships

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7 January 2021

Effects of alkyl chain length on biological activity: alkyl p-aminobenzoate-induced narcosis in goldfish.

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7 January 2021

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

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7 January 2021

10.1016/S0031-6865(96)00031-3

Identifiers

DOI

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29 September 2017

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