The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine (Ethyol). (Q41283946)

29 September 2017

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title

The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine (Ethyol). (English)

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29 September 2017

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Capizzi RL

1

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29 September 2017

1 January 1996

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European Journal of Cancer

29 September 2017

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29 September 2017

32A Suppl 4

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29 September 2017

S5-16

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High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma.

29 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Autologous bone marrow transplantation in patients with acute nonlymphocytic leukemia, using ex vivo marrow treatment with 4-hydroperoxycyclophosphamide

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7 January 2021

Intensive chemotherapy with cyclophosphamide, carmustine, and etoposide followed by autologous bone marrow transplantation for relapsed Hodgkin's disease

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7 January 2021

Cysteine Protection against X Irradiation

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7 January 2021

Treatment of tumours with the combination of WR-2721 and cis-dichlorodiammineplatinum (II) or cyclophosphamide

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

A more general role for WR-2721 in cancer therapy

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Human pharmacokinetics of WR-2721

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Pharmacokinetics of WR-2721.

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7 January 2021

A method for the combined measurement of ethiofos and WR-1065 in plasma: application to pharmacokinetic experiments with ethiofos and its metabolites

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7 January 2021

Protection against radiation-induced mutagenesis at the hprt locus by spermine and N,N"-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamine (WR-33278)

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7 January 2021

Mode of Action of Some Substances Which Protect against the Lethal Effects of X-Rays

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Localized Areas of High Alkaline Phosphatase Activity in Endothelium of Arteries

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7 January 2021

Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Hydrolysis of WR2721 by mouse liver cell fractions

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethyldithiocarbamate

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7 January 2021

Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Enhancement of topoisomerase I-mediated unwinding of supercoiled DNA by the radioprotector WR-33278

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Carboplatin combined with amifostine, a bone marrow protectant, in the treatment of non-small-cell lung cancer: a randomised phase II study

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Amifostine: potential for clinically useful cytoprotection

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

The modification of melphalan toxicity in tumor bearing mice by S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR2721)

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Effects of the modulating agent WR2721 on myelotoxicity and antitumour activity in carboplatin-treated mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Postirradiation treatment with granulocyte colony-stimulating factor and preirradiation WR-2721 administration synergize to enhance hemopoietic reconstitution and increase survival

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

The reversal of cisplatin-protein interactions by the modulating agent WR2721 and its metabolites WR1065 and WR33278

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Reduction of tetrachloro(dl-trans)1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) toxicity by the administration of diethyldithiocarbamate (DDTC), S-2(3-aminopropylamino)ethylphosphorothioic acid (WR-2721), or sodium selenite in the Fischer 344 rat

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Cisplatin nephrotoxicity. A review

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Radiation and the small intestine. Future perspectives for preventive therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

The Effect of S-2-(3-Aminopropylamino)Ethylphosphorothioic Acid (WR-2721) on Intestinal Crypt Survival I. 4 MeV X-Rays

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Intracolonic WR 2721 protection of the rat colon from acute radiation injury

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Cisplatin neuropathy. Risk factors, prognosis, and protection by WR-2721.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Prophylaxis of kanamycin-induced ototoxicity by a radioprotectant

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7 January 2021

Oxygen-dependent protection of radiation lung damage in mice by WR 2721

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Cardioprotection of rat heart myocytes with amifostine (Ethyol) and its free thiol, WR-1065, in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Antimutagenic effects of radioprotector WR-2721 against fission-spectrum neurons and 60Co gamma-rays in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

2-[(Aminopropyl)amino] ethanethiol-mediated reductions in 60Co gamma-ray and fission-spectrum neutron-induced chromosome damage in V79 cells

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https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Concentration-dependent protection against X-ray-induced chromosome aberrations in human lymphocytes by the aminothiol WR-1065

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Radiation protectors: the unexpected benefits

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2896%2900333-4

7 January 2021

10.1016/S0959-8049(96)00333-4

Identifiers

DOI

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29 September 2017

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PubMed ID

8976816