Ribozymes: structure, function, and potential therapy for dominant genetic disorders (Q41337500)

29 September 2017

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title

Ribozymes: structure, function, and potential therapy for dominant genetic disorders (English)

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29 September 2017

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Grassi G

1

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29 September 2017

Marini JC

series ordinal

2

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29 September 2017

language of work or name

English

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publication date

1 December 1996

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29 September 2017

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29 September 2017

volume

28

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29 September 2017

issue

6

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29 September 2017

page(s)

499-510

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RNA enzymes as tools for gene ablation

29 September 2017

cites work

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Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena

21 January 2018

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The chemistry of self-splicing RNA and RNA enzymes

21 January 2018

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Model substrates for an RNA enzyme

21 January 2018

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Simple RNA enzymes with new and highly specific endoribonuclease activities

21 January 2018

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Human hepatitis delta virus RNA subfragments contain an autocleavage activity

21 January 2018

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RNA catalytic properties of the minimum (-)sTRSV sequence

21 January 2018

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Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites

21 January 2018

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Autolytic processing of dimeric plant virus satellite RNA

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853899608999114

A site-specific self-cleavage reaction performed by a novel RNA in Neurospora mitochondria

21 January 2018

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Self-splicing of group I introns

21 January 2018

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Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis

21 January 2018

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Self-splicing introns in prokaryotes: migrant fossils?

21 January 2018

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Compilation of self-cleaving sequences from plant virus satellite RNAs and other sources

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853899608999114

Comparative analysis of cleavage rates after systematic permutation of the NUX consensus target motif for hammerhead ribozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Role of divalent metal ions in the hammerhead RNA cleavage reaction

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853899608999114

Sequence requirements of the hammerhead RNA self-cleavage reaction

21 January 2018

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21 January 2018

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Inhibition of HIV-1 replication by ribozymes that show poor activity in vitro.

21 January 2018

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The influence of imperfectly paired helices I and III on the catalytic activity of hammerhead ribozymes

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853899608999114

Substrate sequence effects on "hammerhead" RNA catalytic efficiency

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853899608999114

A kinetic and thermodynamic framework for the hammerhead ribozyme reaction

21 January 2018

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Satellite tobacco ringspot virus RNA: biological activity of DNA clones and their in vitro transcripts

21 January 2018

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A comprehensive set of sequence analysis programs for the VAX

21 January 2018

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Improved free-energy parameters for predictions of RNA duplex stability

21 January 2018

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Characterization of RNA hairpin loop stability

21 January 2018

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'Hairpin' catalytic RNA model: evidence for helices and sequence requirement for substrate RNA.

21 January 2018

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The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Novel reactions of RNAase P with a tRNA-like structure in turnip yellow mosaic virus RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

A pseudoknot-like structure required for efficient self-cleavage of hepatitis delta virus RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Efficient trans cleavage and a common structural motif for the ribozymes of the human hepatitis delta agent

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Assessment of disparate structural features in three models of the hepatitis delta virus ribozyme

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853899608999114

Comparison of fungal mitochondrial introns reveals extensive homologies in RNA secondary structure

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853899608999114

Conserved sequences and structures of group I introns: building an active site for RNA catalysis--a review

21 January 2018

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The Tetrahymena ribozyme acts like an RNA restriction endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Sequence requirements for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA.

21 January 2018

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Enzymatic activity of the conserved core of a group I self-splicing intron

21 January 2018

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Miniribozymes, small derivatives of the sunY intron, are catalytically active

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853899608999114

External Guide Sequences for an RNA Enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme

21 January 2018

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https://api.crossref.org/works/10.3109%2F07853899608999114

Directed Evolution of Nucleic Acids by Independent Replication and Selection

21 January 2018

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21 January 2018

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Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication

21 January 2018

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In vitro selection of active hairpin ribozymes by sequential RNA-catalyzed cleavage and ligation reactions.

21 January 2018

1 reference

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Selection of a ribozyme that functions as a superior template in a self-copying reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Selection of guide sequences that direct efficient cleavage of mRNA by human ribonuclease P.

21 January 2018

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Evolution in vitro of an RNA enzyme with altered metal dependence

21 January 2018

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Inhibition of replication of HIV-1 by retroviral vectors expressing tat-antisense and anti-tat ribozyme RNA.

21 January 2018

1 reference

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Preformed ribozyme destroys tumour necrosis factor mRNA in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Incorporation of the catalytic domain of a hammerhead ribozyme into antisense RNA enhances its inhibitory effect on the replication of human immunodeficiency virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Inhibition of HIV-1 in human T-lymphocytes by retrovirally transduced anti-tat and rev hammerhead ribozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Resistance to human immunodeficiency virus type 1 infection conferred by transduction of human peripheral blood lymphocytes with ribozyme, antisense, or polymeric trans-activation response element constructs.

21 January 2018

1 reference

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Human gene therapy comes of age.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

The basic science of gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Ribozymes as anti-HIV-1 therapeutic agents: principles, applications, and problems

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Generating loss-of-function phenotypes of the fushi tarazu gene with a targeted ribozyme in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Localized RNAs and their functions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Ribozymes as potential anti-HIV-1 therapeutic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication--potential effectiveness against most presently sequenced HIV-1 isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Mutations in the human gene for fibrillin-1 (FBN1) in the Marfan syndrome and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Human type I procollagen genes are located on different chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Classification of osteogenesis imperfecta by dental characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Genetic heterogeneity in osteogenesis imperfecta

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Antisense oligodeoxynucleotides selectively suppress expression of the mutant alpha 2(I) collagen allele in type IV osteogenesis imperfecta fibroblasts. A molecular approach to therapeutics of dominant negative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Genomic organization of the sequence coding for fibrillin, the defective gene product in Marfan syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Quantitative differences in biosynthesis and extracellular deposition of fibrillin in cultured fibroblasts distinguish five groups of Marfan syndrome patients and suggest distinct pathogenetic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Fibrillin abnormalities and prognosis in Marfan syndrome and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Three-Dimensional Structures of Acidic and Basic Fibroblast Growth Factors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Nature of the interaction of heparin with acidic fibroblast growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

FGFR2 mutations in Pfeiffer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Osteogenesis imperfecta type II delineation of the phenotype with reference to genetic heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

A small catalytic oligoribonucleotide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

Making ends meet: a model for RNA splicing in fungal mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07853899608999114

10.3109/07853899608999114

21 January 2018

Identifiers

DOI

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29 September 2017

1 reference