The role of HIV1 Nef in T-cell activation: Nef impairs induction of Th1 cytokines and interacts with the Src family tyrosine kinase Lck. (Q41338340)

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31 October 2019

review article

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title

The role of HIV1 Nef in T-cell activation: Nef impairs induction of Th1 cytokines and interacts with the Src family tyrosine kinase Lck (English)

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31 October 2019

1

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31 October 2019

Helene Dutartre

series ordinal

2

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31 October 2019

author name string

Benziane A

series ordinal

3

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31 October 2019

Olive D

series ordinal

4

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31 October 2019

language of work or name

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1 January 1997

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31 October 2019

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31 October 2019

volume

148

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31 October 2019

issue

1

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31 October 2019

page(s)

52-58

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Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

31 October 2019

cites work

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HIV-1 Nef protein downregulation of CD4 surface expression: relevance of the lck binding domain of CD4.

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HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

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CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.

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Role of HIV-1 Nef expression in activation pathways in CD4+ T cells

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Negative transcriptional regulation of the interferon-gamma promoter by glucocorticoids and dominant negative mutants of c-Jun

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Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects.

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Evidence for intact CD28 signaling in T cell hyporesponsiveness induced by the HIV-1nef gene

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The when and how of Src regulation

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Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys

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Signal transduction events leading to T-cell lymphokine gene expression

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Evidence for the role of human immunodeficiency virus type 1 Nef protein as a growth inhibitor to CD4+ T lymphocytes and for the blocking of the Nef function by anti-Nef antibodies

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

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Nef 27, but not the Nef 25 isoform of human immunodeficiency virus-type 1 pNL4.3 down-regulates surface CD4 and IL-2R expression in peripheral blood mononuclear cells and transformed T cells

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7 January 2021

Identification of cellular proteins that bind to the human immunodeficiency virus type 1 nef gene product in vitro: a role for myristylation

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7 January 2021

Transcriptional regulation of the IL-2 gene

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7 January 2021

Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity

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7 January 2021

Transactivation by AP-1 is a molecular target of T cell clonal anergy

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7 January 2021

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

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7 January 2021

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

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7 January 2021

Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgene

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7 January 2021

Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells

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7 January 2021

Evidence for intact costimulation via CD28 and CD27 molecules in hyporesponsive T cells from human immunodeficiency virus-infected individuals

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7 January 2021

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

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7 January 2021

The HIV-1 regulatory protein Nef has a specific function in viral expression in a murine macrophage cell line.

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7 January 2021

HIV-1 Nef protein inhibits the recruitment of AP-1 DNA-binding activity in human T-cells

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7 January 2021

Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling

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7 January 2021

Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn

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7 January 2021

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

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7 January 2021

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

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7 January 2021

Activation pathways and human immunodeficiency virus type 1 replication are not altered in CD4+ T cells expressing the nef protein.

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7 January 2021

Reduced cell surface expression of processed human immunodeficiency virus type 1 envelope glycoprotein in the presence of Nef.

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7 January 2021

Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo

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7 January 2021

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene

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7 January 2021

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

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7 January 2021

Transcription of the interleukin 4 gene is regulated by multiple promoter elements

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7 January 2021

10.1016/S0923-2516(97)81914-0

Identifiers

DOI

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31 October 2019

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