Membrane metalloendopeptidase (Q414232)

Neprilysin

1 reference

Peptidase M13, C-terminal domain, protein family

Enkephalinase (human)

0 references

1 reference

based on heuristic

inferred from protein domain or family

Peptidase M13, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

Hydrolysis of substance P and neurotensin by converting enzyme and neutral endopeptidase

exopeptidase activity

1 reference

8 April 2019

GOA

curator

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126)

endopeptidase activity

4 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

3 January 2017

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

3 January 2017

Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

3 January 2017

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

metalloendopeptidase activity

4 references

8 April 2019

Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

GOA

curator

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

metallopeptidase activity

phosphatidylserine binding

EXP

3 references

1 reference

8 April 2019

Localization of mature neprilysin in lipid rafts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126)

endopeptidase activity

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

protein homodimerization activity

1 reference

8 April 2019

Localization of mature neprilysin in lipid rafts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

oligopeptidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

1 reference

8 April 2019

Localization of mature neprilysin in lipid rafts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

1 reference

8 April 2019

CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

1 reference

3 January 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

integral component of plasma membrane

1 reference

8 April 2019

Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

NAS

extracellular exosome

3 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

3 January 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

3 January 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

2 references

secretory granule membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

1 reference

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

1 reference

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

1 reference

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

1 reference

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

1 reference

8 April 2019

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

IGI

biological process

angiotensin maturation

1 reference

8 April 2019

cellular response to UV-B

TAS

1 reference

8 April 2019

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

cellular response to cytokine stimulus

1 reference

8 April 2019

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

1 reference

3 January 2017

CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

IEP

replicative senescence

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

cellular response to UV-A

IEP

1 reference

8 April 2019

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

creatinine metabolic process

1 reference

8 April 2019

Genetic and functional effects of membrane metalloendopeptidase on diabetic nephropathy development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

6 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

3 January 2017

Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

3 January 2017

Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

3 January 2017

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08473

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

neutrophil degranulation

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

12 references

8 April 2019

Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

1 reference

8 April 2019

Neprylisin decreases uniformly in Alzheimer's disease and in normal aging.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

1 reference

8 April 2019

A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

positive regulation of neurogenesis

1 reference

8 April 2019

A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis

IGI

neuropeptide processing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

IGI

amyloid-beta clearance

5 references

8 April 2019

8 April 2019

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

amyloid-beta clearance by cellular catabolic process

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

8 April 2019

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

positive regulation of long-term synaptic potentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08473

http://purl.uniprot.org/uniprot/P08473

Gene Atlas image

PBB GE MME 203434 s at fs.png
732 × 530; 10 KB

0 references

exact match

1 reference

Peptidase M13, N-terminal domain

Identifiers.org

has part(s)

1 reference

Peptidase M13, C-terminal domain

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016