Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression (Q41459186)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28821815%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

title

Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression (English)

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27 March 2020

6

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27 March 2020

Stein-Ove Døskeland

12

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27 March 2020

author name string

Gyrid Nygaard

1

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27 March 2020

Lars Herfindal

2

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27 March 2020

Kathrine S Asrud

3

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27 March 2020

Ronja Bjørnstad

4

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27 March 2020

Reidun K Kopperud

5

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27 March 2020

Frode S Berven

7

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27 March 2020

Lene Myhren

8

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27 March 2020

Erling A Hoivik

9

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27 March 2020

Turid Helen Felli Lunde

10

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27 March 2020

Marit Bakke

11

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27 March 2020

Frode Selheim

13

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27 March 2020

language of work or name

English

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publication date

18 August 2017

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27 March 2020

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27 March 2020

volume

7

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27 March 2020

page(s)

8725

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27 March 2020

issue

1

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Creative Commons Attribution 4.0 International

27 March 2020

copyright license

start time

18 August 2017

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5562764/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/s41598-017-08975-y

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11 June 2018

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11 June 2018

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11 June 2018

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Clinical and genetic aspects of Bernard-Soulier syndrome: searching for genotype/phenotype correlations

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Talin-dependent integrin activation is required for fibrin clot retraction by platelets

11 June 2018

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The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function

11 June 2018

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Platelet adhesion under flow

11 June 2018

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A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion

11 June 2018

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Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells

11 June 2018

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Template bleeding times of 240 neonates born at 24 to 41 weeks gestation

11 June 2018

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Activation of Epac stimulates integrin-dependent homing of progenitor cells

11 June 2018

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Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet

11 June 2018

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Epac1-Rap1 signaling regulates monocyte adhesion and chemotaxis

11 June 2018

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The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3

11 June 2018

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11 June 2018

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The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin

11 June 2018

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Different effects of abciximab and cytochalasin D on clot strength in thrombelastography

11 June 2018

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cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension

11 June 2018

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A novel missense mutation shows that GPIbbeta has a dual role in controlling the processing and stability of the platelet GPIb-IX adhesion receptor

11 June 2018

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Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor

11 June 2018

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11 June 2018

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A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

11 June 2018

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Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis

11 June 2018

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Increased thrombin responsiveness in platelets from mice lacking glycoprotein V

11 June 2018

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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

11 June 2018

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Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow.

11 June 2018

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The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration

11 June 2018

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Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation

11 June 2018

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Regulation of megakaryocyte ploidy in vivo in the rat.

11 June 2018

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Efficient plasma membrane expression of a functional platelet glycoprotein Ib-IX complex requires the presence of its three subunits

11 June 2018

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Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression.

11 June 2018

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Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets.

19 August 2018

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19 August 2018

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The platelet glycoprotein GPIbbeta intracellular domain participates in von Willebrand factor induced-filopodia formation independently of the Ser 166 phosphorylation site.

19 August 2018

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Timed feeding of mice modulates light-entrained circadian rhythms of reticulated platelet abundance and plasma thrombopoietin and affects gene expression in megakaryocytes.

19 August 2018

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Developmental differences in megakaryocyte maturation are determined by the microenvironment.

19 August 2018

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Protein kinase A mediates inhibition of the thrombin-induced platelet shape change by nitric oxide

19 August 2018

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Genetic deletion of mouse platelet glycoprotein Ibbeta produces a Bernard-Soulier phenotype with increased alpha-granule size.

19 August 2018

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19 August 2018

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Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide Recognition

19 August 2018

1 reference

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7 January 2021

Adrenaline potentiates PI 3-kinase in platelets stimulated with thrombin and SFRLLN: role of secreted ADP

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7 January 2021

VEGFR1 stimulates a CXCR4-dependent translocation of megakaryocytes to the vascular niche, enhancing platelet production in mice

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7 January 2021

Disseminated intravascular coagulation

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7 January 2021

Reductions in platelet contractile force correlate with duration of cardiopulmonary bypass and blood loss in patients undergoing cardiac surgery

1 reference

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7 January 2021

Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype

1 reference

12 December 2020

Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand

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12 December 2020

Bernard-Soulier syndrome

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12 December 2020

Mean platelet volume, an indicator of platelet activation, is increased in patients with mitral stenosis and sinus rhythm

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12 December 2020

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12 December 2020

10.1038/S41598-017-08975-Y

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28821815%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28821815%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

1 reference