Leydig cell hyperplasia and adenoma formation: mechanisms and relevance to humans (Q41460883)

1 October 2017

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title

Leydig cell hyperplasia and adenoma formation: mechanisms and relevance to humans (English)

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1 October 2017

3

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1 October 2017

E D Clegg

1

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1 October 2017

J C Cook

series ordinal

2

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1 October 2017

P M Foster

series ordinal

4

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1 October 2017

G P Daston

series ordinal

5

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1 October 2017

1 January 1997

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1 October 2017

Reproductive Toxicology

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1 October 2017

11

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1 October 2017

107-121

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1 October 2017

1

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https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

1 October 2017

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

1 reference

7 January 2021

Mechanism for species-specific induction of Leydig cell tumors in rats by lansoprazole

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Differentiation of adult Leydig cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Increase in Leydig cell number in testes of adult rats treated chronically with an excess of human chorionic gonadotropin

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Leydig cell hyperplasia and adenomas in mice treated with finasteride, a 5 alpha-reductase inhibitor: a possible mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Cell-cell interactions in the testis

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Growth factors as mediators of testicular cell-cell interactions

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https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Evidence for leydig cell dysfunction in rats with seminiferous tubule damage

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

A Sertoli cell-secreted paracrine factor(s) stimulates proliferation and inhibits steroidogenesis of rat Leydig cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Regeneration of Leydig cells in unilaterally cryptorchid rats: evidence for stimulation by local testicular factors

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Selective depletion of testicular macrophages and prevention of Leydig cell repopulation after treatment with ethylene dimethane sulfonate in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Leydig cell mitoses in human testes bearing early germ cell tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Novel expression of luteinizing hormone subunit genes in the rat testis

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Constitutive steroidogenesis in the R2C Leydig tumor cell line is maintained by the adenosine 3',5'-cyclic monophosphate-independent production of a cycloheximide-sensitive factor that enhances mitochondrial pregnenolone biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

A review of drug-induced Leydig cell hyperplasia and neoplasia in the rat and some comparisons with man.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Effect of polybrominated biphenyls on hepatic microsomal metabolism of estrogens and uterotropic action of administered estrogen in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Hyperprolactinemia inhibits development of Leydig cell tumors in aging Fischer rats

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Early indicators for carcinogenesis in sex-hormone-sensitive organs

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Endocrinological and histological changes induced by flutamide treatment on the hypothalamo-hypophyseal testicular axis of the adult male rat and their incidences on fertility

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Effect of a non-steroidal antiandrogen, flutamide, on the hypothalamo-pituitary axis, genital tract and testis in growing male rats: endocrinological and histological data.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

A two-year study with cimetidine in the rat: Assessment for chronic toxicity and carcinogenicity

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

The effects of histamine H2 receptor antagonists on androgen action in vivo and dihydrotestosterone binding to the rat prostate androgen receptor in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

The affinity of procymidone to androgen receptor in rats and mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Effects of procymidone on reproductive organs and serum gonadotropins in male rats

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Species-specific mechanism in rat Leydig cell tumorigenesis by procymidone

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Ketoconazole and other imidazole derivatives as inhibitors of steroidogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Changes induced by treatment with aromatase inhibitors in testicular Leydig cells of rats and dogs

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Mesulergine induced Leydig cell tumours, a syndrome involving the pituitary-testicular axis of the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Carcinogenicity studies of oxolinic acid in rats and mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

The correlation of serum luteinizing hormone levels with the induction of Leydig cell tumors in rats by oxolinic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

A possible mechanism for the increase in serum luteinizing hormone levels in male rats by oxolinic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Investigations of the carcinogenicity of the LH-RH analog buserelin (HOE 766) in rats using the subcutaneous route of administration

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Stimulation and inhibition by LHRH analogues of cultured rat Leydig cell function and lack of effect on mouse Leydig cells

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Lack of Influence of Hypophysectomy on Estrogen-Induced DNA Synthesis in Leydig Cells of BALB/c Mice2

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Leydig cell hyperplasia in fetal mice treated transplacentally with ethinyl estradiol

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Long-term effects on male reproductive organs of prenatal exposure to ethinyl estradiol

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Autocrine regulation of cell proliferation by estradiol and hydroxytamoxifen of transformed mouse Leydig cells in serum-free culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Effects of Chronic Hyperprolactinemia in Mice on Plasma Gonadotropin Concentrations and Testicular Human Chorionic Gonadotropin Binding Sites*

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Interactions of human growth hormone and prolactin on pituitary and Leydig cell function in adult transgenic mice expressing the human growth hormone gene

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Hepatic peroxisome proliferation in rodents and its significance for humans

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Chemically induced proliferation of peroxisomes: implications for risk assessment

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Two-year inhalation toxicity study in rats with hydrochlorofluorocarbon 123.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Comparison of the effects of Wyeth-14,643 in Crl:CD BR and Fisher-344 rats

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Induction of Leydig cell adenomas by ammonium perfluorooctanoate: a possible endocrine-related mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Effects of Ammonium Perfluorooctanoate on Leydig-Cell Function: In Vitro, in Vivo, and ex Vivo Studies

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

The direct effect of hepatic peroxisome proliferators on rat Leydig cell function in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Gonadotrophin receptors: correlates with normal and pathological functions of the human ovary and testis

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

The mechanisms of LHRH agonist action in gonadal tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Absence of gonadotropin-releasing hormone receptors in human gonadal tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Evaluation of the possible direct effects of gonadotrophin-releasing hormone analogues on the monkey (Macaca mulatta) testis

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Mice Are Insensitive to the Antitesticular Effects of Luteinizing Hormone-Releasing Hormone Agonists*

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Quantification of Leydig cells and measurement of Leydig-cell size following administration of human chorionic gonadotrophin to normal men

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Luteinizing hormone secretory pattern before and after removal of Leydig cell tumor of the testis.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Immunohistological determination of oestrogen receptor, progesterone receptor, and intermediate filaments in Leydig cell tumours, Leydig cell hyperplasia, and normal Leydig cells of the human testis

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Monoclonality and abnormal parathyroid hormone genes in parathyroid adenomas

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Non-germ cell tumors of testis

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Gonadal stromal tumors: a report of the Prepubertal Testicular Tumor Registry

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Metastatic Leydig cell tumor of the testis. Report of three cases and review of the literature

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Metachronous germ cell and Leydig cell tumors of the testis. Do testicular germ cell tumors and Leydig cell tumors share common etiologic factors?

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Intraoperative ultrasound in the conservative resection of testicular neoplasms

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Management of testicular masses incidentally discovered by ultrasound.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Interstitial cell tumours of the testis; two cases and survey

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Chronic toxicity and carcinogenicity evaluation of fenvalerate in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

The binding properties of pyrethroids to human skin fibroblast androgen receptors and to sex hormone binding globulin

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

The Effect of the Steroidal Androgen Receptor Antagonist, Win 49,596, on the Prostate and Testis of Beagle Dogs

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

The effect of a 5 alpha-reductase inhibitor on androgen physiology in the immature male rat

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Inhibition of testosterone biosynthesis in testicular microsomes by various imidazole drugs. Comparative study with ketoconazole

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Ethylene dichloride: the influence of disulfiram or ethanol on oncogenicity, metabolism, and DNA covalent binding in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Inhibition of testosterone synthesis by ethanol: role of luteinizing hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Experimental Induction of Hepatomas, Mammary Tumors, and Other Tumors With Metronidazole in Noninbred Sas:MRC(WI)BR Rats2

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Induction, suppression and inhibition of multiple hepatic cytochrome P450 isozymes in the male rat and bobwhite quail (Colinus virginianus) by ergosterol biosynthesis inhibiting fungicides (EBIFs).

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Testicular Leydig cell tumourigenesis by diethylstilbestrol in the BALB/c mouse. Histologic and histochemical study

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Interstitial cell carcinomas of the testis in Balb/C male mice ingesting methoxychlor

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Evaluation of the carcinogenic potential of pesticides. 4. Chloroalkylthiodicarboximide compounds with fungicidal activity

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Effects of neonatal administration of the reversible goitrogen propylthiouracil on the testis interstitium in adult rats

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Genotoxicity and carcinogenicity of fluorocarbons: assessment by short-term in vitro tests and chronic exposure in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

1,1,1,2-Tetrafluoroethane: repeat exposure inhalation toxicity in the rat, developmental toxicity in the rabbit, and genotoxicity in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Safety assessment of HCFC-141b: use as a blowing agent for insulation in building construction and refrigeration

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Subacute and chronic toxicity studies of trinitroglycerin in dogs, rats, and mice

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Chronic effects of agar, guar gum, gum arabic, locust-bean gum, or tara gum in F344 rats and B6C3F1 mice

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Chronic oral toxicity and oncogenicity studies of flecainide, an antiarrhythmic, in rats and mice

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Long term tumorigenicity of a single application of indomethacin or Amuno in adolescent and in adult male Sprague Dawley rats

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

The toxicologic and oncogenic potential of JP-4 jet fuel vapors in rats and mice: 12-month intermittent inhalation exposures.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Methyl-tertiary-butyl ether (MTBE)--a gasoline additive--causes testicular and lymphohaematopoietic cancers in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Effects of chronic nicotine administration and age in male Fischer-344 rats

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Comparative carcinogenicity of N-nitrosobis(2-oxopropyl)-amine and N-nitrosomethyl(2-oxopropyl)amine following subcutaneous or oral administration to rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Inhalation toxicity studies with 1,3-butadiene. 3. Two year toxicity/carcinogenicity study in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Carcinogenesis induced by combined neonatal exposure to 5-bromo-2'-deoxyuridine and subsequent total-body X-ray irradiation in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Carcinogenicity of nitrosamines and methanesulphonate esters given intraperitoneally, in RF mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

A synergistic effect of nitrosodimethylamine on sterigmatocystin carcinogenesis in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Neoplastic Lesions in Streptozotocin-treated Rats

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

The tumorigenicity of 5-azacytidine in the male Fischer rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Carcinogenicity and haemoglobin synthesis induction by cytidine analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Chronic effects on single and multiple oral and subcutaneous cadmium administrations on the testes of Wistar rats

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

Carcinogenicity of oral cadmium in the male Wistar (WF/NCr) rat: effect of chronic dietary zinc deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0890-6238%2896%2900203-1

7 January 2021

10.1016/S0890-6238(96)00203-1

Identifiers

DOI

1 reference

1 October 2017

1 reference