Oxidative stress hypothesis in Alzheimer's disease (Q41482152)

1 October 2017

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title

Oxidative stress hypothesis in Alzheimer's disease (English)

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1 October 2017

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Markesbery WR

1

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1 October 2017

1 January 1997

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Free Radical Biology and Medicine

1 October 2017

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1 October 2017

23

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1 October 2017

134-147

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1 October 2017

1

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Editorial: The prevalence and malignancy of Alzheimer disease. A major killer

1 October 2017

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Diagnosis of Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

The cholinergic hypothesis of geriatric memory dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Presynaptic serotonergic dysfunction in patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

The epidemiology of Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

The prevalence of dementia and Alzheimer's disease in Shanghai, China: impact of age, gender, and education

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Oxidative stress, glutamate, and neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

A radical hypothesis for neurodegeneration

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Lipid peroxidation as cause of nigral cell death in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Iron, selenium and glutathione peroxidase activity are elevated in sporadic motor neuron disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Neutron Activation Analysis of Trace Elements in Motor Neuron Disease Spinal Cord

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Elemental imbalances in the olfactory pathway in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: a laser microprobe (LAMMA) study

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Ferritin: isolation of aluminum-ferritin complex from brain

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia.

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Serum levels of the iron binding protein p97 are elevated in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Effects of aluminum on brain lipid peroxidation

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

A mechanism for the stimulatory effect of aluminum on iron-induced lipid peroxidation

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Cellular toxicity and lipid peroxidation in response to mercury

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Ceruloplasmin levels in the human superior temporal gyrus in aging and Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Effects of ceruloplasmin on superoxide-dependent iron release from ferritin and lipid peroxidation

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Electron paramagnetic resonance investigations of free radical-induced alterations in neocortical synaptosomal membrane protein infrastructure

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Evidence of an oxidative challenge in the Alzheimer's brain

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Brain membrane fluidity and lipid peroxidation in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

The role of alterations in membrane lipid composition in enabling physiological adaptation of organisms to their physical environment

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Evidence for a membrane defect in Alzheimer disease brain

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II).

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

4-hydroxynonenal inhibits Na(+)-K(+)-ATPase

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Crosslinking of apolipoprotein E by products of lipid peroxidation.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Brain glutathione peroxidase in neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Decreased catalase activity but unchanged superoxide dismutase activity in brains of patients with dementia of Alzheimer type.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Concentrations of several proteins characteristic of nervous tissue in cerebral cortex of patients with alzheimer’s disease

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Free radicals in the genesis of Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Superoxide dismutase isoenzymes in normal brains and in brains from patients with dementia of Alzheimer type.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Nonenzymatic browning in vivo: possible process for aging of long-lived proteins

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https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Radical AGEing in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Oxidative glycation and free radical production: a causal mechanism of diabetic complications

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Advanced glycation end products contribute to amyloidosis in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Advanced Maillard reaction end products are associated with Alzheimer disease pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Oxidative damage in Alzheimer's.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Morphometric analysis of microglia in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Hydrogen peroxide mediates amyloid beta protein toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

beta-Amyloid-mediated vasoactivity and vascular endothelial damage.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Aging, energy, and oxidative stress in neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Brain oxidative energy and related metabolism, neuronal stress, and Alzheimer's disease: a speculative synthesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Diseases of the mitochondrial DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Age-dependent impairment of mitochondrial function in primate brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

The mitochondrial electron transfer alteration as a factor involved in the brain aging.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Electron transport chain defects in Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Brain Cytochrome Oxidase in Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Cortical cytochrome oxidase activity is reduced in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Functional alterations in Alzheimer's disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Cytochrome c oxidase in Alzheimer's disease brain: purification and characterization

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Spin trapping of azidyl and hydroxyl radicals in azide-inhibited rat brain submitochondrial particles.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Excitatory amino acids as a final common pathway for neurologic disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Current concepts of excitotoxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Mechanisms of phospholipase A2 activation and neuronal injury

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Oxygen-derived free radicals in postischemic tissue injury

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

B- Amyloid increases neuronal susceptibility to injufy by glucose deprivation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Mechanism of kainate toxicity to cerebellar neurons in vitro is analogous to reperfusion tissue injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Amyloid beta-peptide and oxidative cellular injury in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Role of nerve growth factor in oxidant-antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Role of nerve growth factor in oxidant homeostasis: glutathione metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

PDGFs protect hippocampal neurons against energy deprivation and oxidative injury: evidence for induction of antioxidant pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Nonsteroidal anti-inflammatory drugs in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

Intramuscular desferrioxamine in patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2896%2900629-6

7 January 2021

10.1016/S0891-5849(96)00629-6

Identifiers

DOI

1 reference

1 October 2017

1 reference

PubMed ID

9165306