The proto-oncogene Bcl-2 and its role in regulating apoptosis (Q41492030)

1 October 2017

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title

The proto-oncogene Bcl-2 and its role in regulating apoptosis (English)

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1 October 2017

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1

Kroemer G

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PubMed ID

9176486

1 October 2017

language of work or name

English

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publication date

1 June 1997

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1 October 2017

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1 October 2017

3

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1 October 2017

614-620

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1 October 2017

6

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https://scigraph.springernature.com/pub.10.1038/nm0697-614

1 October 2017

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cites work

Apoptosis in the pathogenesis and treatment of disease

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

The biochemistry of programmed cell death

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Bcl-2 and the regulation of programmed cell death

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

The mitochondrial permeability transition.

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Mitochondrial control of apoptosis

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Bcl-2 targets the protein kinase Raf-1 to mitochondria

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Interaction and regulation of subcellular localization of CED-4 by CED-9

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Bax-independent inhibition of apoptosis by Bcl-XL.

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

A peptide sequence from Bax that converts Bcl-2 into an activator of apoptosis

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

BID: a novel BH3 domain-only death agonist

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax.

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Functional dissection of the human Bc12 protein: sequence requirements for inhibition of apoptosis

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Bcl-x(L) forms an ion channel in synthetic lipid membranes.

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Intracellular calcium stores are not required for Bcl-2-mediated protection from apoptosis.

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Mitochondrial control of nuclear apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Release of cytochrome c from liver mitochondria during permeability transition.

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL.

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Constitutive expression of the machinery for programmed cell death

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Bcl-2 promotes regeneration of severed axons in mammalian CNS

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53.

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Microtubule-active drugs suppress the closure of the permeability transition pore in tumour mitochondria

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1 reference

https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2.

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

BCL-2 and MCL-1 expression in Chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine

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https://api.crossref.org/works/10.1038%2FNM0697-614

7 January 2021

Identifiers

DOI

10.1038/NM0697-614

1 reference

1 October 2017

1 reference

PubMed ID

9176486