DNA-PK: at the cross-roads of biochemistry and genetics (Q41513507)

2 October 2017

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title

DNA-PK: at the cross-roads of biochemistry and genetics (English)

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2 October 2017

P A Jeggo

1

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2 October 2017

language of work or name

English

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publication date

1 June 1997

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2 October 2017

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2 October 2017

volume

384

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2 October 2017

issue

1

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2 October 2017

page(s)

1-14

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Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap

2 October 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Production and characterization of recombinant human Ku antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Analysis of the mechanism of interaction of simian Ku protein with DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

When is a lipid kinase not a lipid kinase? When it is a protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

The cellular responses to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

The ataxia-telangiectasia gene: a link between checkpoint controls, neurodegeneration and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Genetic analysis of ionising radiation sensitive mutants of cultured mammalian cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

The genetic basis of resistance to ionising radiation damage in cultured mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Nomenclature of human genes involved in ionizing radiation sensitivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Menage à trois: double strand break repair, V(D)J recombination and DNA-PK.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Mammalian mutants defective in the response to ionizing radiation-induced DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Impairment of V(D)J recombination in double-strand break repair mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Studies on mammalian mutants defective in rejoining double-strand breaks in DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Molecular and biochemical characterization of xrs mutants defective in Ku80.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the Ku80 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

A severe combined immunodeficiency mutation in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Dose-rate effect on induction and repair rate of radiation-induced DNA double-strand breaks in a normal and an ataxia telangiectasia human fibroblast cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Radiosensitivity in ataxia-telangiectasia: a new explanation

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

X-ray sensitive mutants of Chinese hamster ovary cell line: radio-sensitivity of DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

A DNA end-binding factor involved in double-strand break repair and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

DNA damage and the DNA-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Double-strand break repair and G2 block in Chinese hamster ovary cells and their radiosensitive mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

In vivo biochemistry: physical monitoring of recombination induced by site-specific endonucleases.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Intermolecular recombination between DNAs introduced into mouse L cells is mediated by a nonconservative pathway that leads to crossover products

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Two alternative pathways of double-strand break repair that are kinetically separable and independently modulated

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

RAD1 and RAD10, but not other excision repair genes, are required for double-strand break-induced recombination in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

ERCC4 (XPF) encodes a human nucleotide excision repair protein with eukaryotic recombination homologs

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Evidence that mammalian cells possess homologous recombinational repair pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Formation of large deletions by illegitimate recombination in the HPRT gene of primary human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Mechanisms of nonhomologous recombination in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Relative rates of homologous and nonhomologous recombination in transfected DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52-independent, nonhomologous recombination events

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Homologous, homeologous, and illegitimate repair of double-strand breaks during transformation of a wild-type strain and a rad52 mutant strain of Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Decreased stable transfection frequencies of six X-ray-sensitive CHO strains, all members of the xrs complementation group

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Gene recombination in X-ray-sensitive hamster cells

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Genotoxicity of gamma-irradiation in L5178Y mouse lymphoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Chromosomal double-strand break repair in Ku80-deficient cells

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Cell cycle-dependent repair of double-strand DNA breaks in a gamma-ray-sensitive Chinese hamster cell

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Cell cycle responses of two X-ray sensitive mutants defective in DNA repair

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

DNA double-strand break rejoining in xrs5 cells is more rapid in the G2 than in the G1 phase of the cell cycle.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Loss of S-phase-dependent radioresistance in irs-1 cells exposed to X-rays

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

A double-strand break within a yeast artificial chromosome (YAC) containing human DNA can result in YAC loss, deletion or cell lethality

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

The RAD52 gene is required for homothallic interconversion of mating types and spontaneous mitotic recombination in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

1 reference

7 January 2021

Molecular analysis of V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Initiation of V(D)J recombination in a cell-free system.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Biochemical and cytogenetical characterization of Chinese hamster ovary X-ray-sensitive mutant cells xrs 5 and xrs 6. V. The correlation of DNA strand breaks and base damage to chromosomal aberrations and sister-chromatid exchanges induced by X-irra

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

TFIIH: a key component in multiple DNA transactions

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Sequence-specific DNA binding by Ku autoantigen and its effects on transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Differential gene expression in wild-type and X-ray-sensitive mutants of Chinese hamster ovary cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Accelerated telomere shortening in ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Use of damaged plasmid to study DNA repair in X-ray sensitive (xrs) strains of Chinese hamster ovary (CHO) cells

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Ku is a general inhibitor of DNA-protein complex formation and transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Isolation of cell cycle-dependent gamma ray-sensitive Chinese hamster ovary cell

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

Isolation of mammalian cell mutants that are X-ray sensitive, impaired in DNA double-strand break repair and defective for V(D)J recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS0921-8777%2897%2900009-8

7 January 2021

10.1016/S0921-8777(97)00009-8

Identifiers

DOI

1 reference

2 October 2017

1 reference