Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome (Q41575247)

4 October 2017

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title

Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome (English)

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4 October 2017

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Hinnebusch AG

1

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PubMed ID

9268289

4 October 2017

language of work or name

English

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publication date

1 August 1997

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Journal of Biological Chemistry

4 October 2017

4

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based on heuristic

inferred from page(s)

published in

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4 October 2017

272

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4 October 2017

21661-21664

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4 October 2017

35

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Translational control in mammalian cells

4 October 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Multiple upstream AUG codons mediate translational control of GCN4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Requirements for intercistronic distance and level of eukaryotic initiation factor 2 activity in reinitiation on GCN4 mRNA vary with the downstream cistron

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Sequences that surround the stop codons of upstream open reading frames in GCN4 mRNA determine their distinct functions in translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

The first and fourth upstream open reading frames in GCN4 mRNA have similar initiation efficiencies but respond differently in translational control to change in length and sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

The positive regulatory function of the 5'-proximal open reading frames in GCN4 mRNA can be mimicked by heterologous, short coding sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Sequences 5' of the first upstream open reading frame in GCN4 mRNA are required for efficient translational reinitiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Mutations at a Zn(II) finger motif in the yeast eIF-2 beta gene alter ribosomal start-site selection during the scanning process.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

GCD11, a negative regulator of GCN4 expression, encodes the gamma subunit of eIF-2 in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Multiple GCD genes required for repression of GCN4, a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

A segment of GCN4 mRNA containing the upstream AUG codons confers translational control upon a heterologous yeast transcript

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Mutations in the structural genes for eukaryotic initiation factors 2 alpha and 2 beta of Saccharomyces cerevisiae disrupt translational control of GCN4 mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Molecular characterization of GCD1, a yeast gene required for general control of amino acid biosynthesis and cell-cycle initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Negative regulatory gene for general control of amino acid biosynthesis in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Identification and characterization of four new GCD genes in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Complex formation by positive and negative translational regulators of GCN4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Translational control of GCN4: an in vivo barometer of initiation-factor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA(Asp)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Genetic evidence for functional specificity of the yeast GCN2 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Cloning and characterization of a cDNA encoding a protein synthesis initiation factor-2alpha (eIF-2alpha) kinase from Drosophila melanogaster. Homology To yeast GCN2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21661

21 January 2018

Identifiers

DOI

10.1074/JBC.272.35.21661

1 reference

release_yk4ma46dazcclhae6zke53kmpi

4 October 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yk4ma46dazcclhae6zke53kmpi

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24 November 2022

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PubMed ID

9268289

1 reference

PubMed ID

9268289