Application of the in vitro rat hepatocyte micronucleus assay in genetic toxicology testing (Q41575648)

4 October 2017

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title

Application of the in vitro rat hepatocyte micronucleus assay in genetic toxicology testing (English)

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4 October 2017

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Müller-Tegethoff K

1

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4 October 2017

Kersten B

series ordinal

2

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4 October 2017

Kasper P

series ordinal

3

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4 October 2017

Müller L

series ordinal

4

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4 October 2017

language of work or name

English

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publication date

1 August 1997

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4 October 2017

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4 October 2017

392

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4 October 2017

1-2

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4 October 2017

125-138

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Mutagenicity testing with the Salmonella/hepatocyte and the Salmonella/microsome assays. A comparative study with some known genotoxic compounds.

4 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Induction of SCEs by some pyrrolizidine alkaloids in V79 Chinese hamster cells co-cultured with chick embryo hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Mutagenicity of 4-hydroxynonenal in V79 Chinese hamster cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Flow cytometric analysis of in vitro micronucleus induction in hepatocytes treated with carcinogens

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Collagenase perfusion of rat liver induces DNA damage and DNA repair in hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Occurrence and possible consequences of multipolar mitoses in primary cultures of adult rat hepatocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Genotoxic properties of 4-hydroxyalkenals and analogous aldehydes

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Induction of sister chromatid exchanges in cultured adult rat hepatocytes by directly and indirectly acting mutagens/carcinogens

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

The effects of a purified diet on sister chromatid exchange frequencies and mitotic activity in adult rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Effects of EGF and calcium on adult parenchymal hepatocyte proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Hydroxynonenal, a component of clastogenic factors?

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Possible mutagens derived from lipids and lipid precursors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Cyto- and genotoxic potential of the photosensitizer Photosan 3 in the absence of light

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: evaluations of 108 chemicals

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Induction of sister chromatid exchange and micronuclei in primary cultures of rat and human hepatocytes by the peroxisome proliferator, Wy-14,643

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

In vitro mutagenicity studies on cyproterone acetate using female rat hepatocytes for metabolic activation and as indicator cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Induction of SCE by indirect mutagens in cultured rat hepatoma cells and in Chinese hamster V79 cells co-cultivated with hepatocyte primary cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

The effectiveness of S9 and microsomal mix on activation of cyclophosphamide to induce genotoxicity in human lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Development of short-term mutagenicity test systems in vitro: metabolic activation of indirectly acting mutagens by three immortal rat hepatocyte lines

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Direct or proximate contact between cells and metabolic activation systems is required for mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Studies for a genotoxic potential of some endogenous and exogenous sex steroids. I. Communication: examination for the induction of gene mutations using the Ames Salmonella/microsome test and the HGPRT test in V79 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Evaluation of experimental parameters in an S9/human leukocyte SCE test with cyclophosphamide

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

DNA repair synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes exposed to cyproterone acetate

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Induction of micronuclei and initiation of enzyme-altered foci in the liver of female rats treated with cyproterone acetate, chlormadinone acetate, or megestrol acetate.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Pyruvate promotion of DNA synthesis in serum-free primary cultures of adult rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

DNA synthesis in primary cultures of adult rat hepatocytes in a defined medium: Effects of epidermal growth factor, insulin, glucagon, and cyclic-AMP

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Evaluation of the micronucleus test in vitro using Chinese hamster cells: results of four chemicals weakly positive in the in vivo micronucleus test

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Further mutagenicity studies on pesticides in bacterial reversion assay systems

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

An assessment of the in vitro hepatocyte micronucleus assay.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Lack of AFB(1)-induced mutagenicity in the in vitro hepatocyte micronucleus assay: Investigation of possible mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

The clastogenic potential in vitro of pyrrolizidine alkaloids employing hepatocyte metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Evaluation studies on the in vitro rat hepatocyte micronucleus assay.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Density-dependent growth control of adult rat hepatocytes in primary culture

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https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Cyproterone acetate induces DNA damage in cultured rat hepatocytes and preferentially stimulates DNA synthesis in gamma-glutamyltranspeptidase-positive cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Establishment of two rat hepatoma cell strains produced by a carcinogen initiation, phenobarbital promotion protocol

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Effect of inducers of cytochrome P-450 on the metabolism of [3-14C]coumarin by rat hepatic microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Increase of micronucleus frequency in cultured rat hepatocytes treated in vitro with benomyl and pirimiphos-methyl separately and in mixture.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Mutagenic properties of pirimiphos-methyl in male mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Postlabeling methods for carcinogen-DNA adduct analysis

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https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

32P-labeling test for DNA damage

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https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Oxidative DNA damage caused by persistent peroxisome proliferation: its role in hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Genotoxic effects of selected peroxisome proliferators.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Specificity of rat liver cytochrome P-450 isozymes in the mutagenic activation of benzo[a]pyrene, aromatic amines and aflatoxin B1

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Mutagenicity, clastogenicity and cytotoxicity of procarcinogens in a rat hepatoma cell line competent for xenobiotic metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

The polyploidizing growth pattern of normal rat liver is replaced by divisional, diploid growth in hepatocellular nodules and carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Temporal requirement for epidermal growth factor and insulin in the stimulation of hepatocyte DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Extracellular matrix components influence DNA synthesis of rat hepatocytes in primary culture

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Chromosome aberrations, micronuclei and sister-chromatid exchanges (SCEs) in rat liver induced in vivo by hepatocarcinogens including heterocyclic amines

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Adaptive responses of rat liver to the gestagen and anti-androgen cyproterone acetate and other inducers. II. Induction of growth

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Metabolism of carcinogenic amino derivatives in various species and DNA alkylation by their metabolites

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Further evaluation of a modified micronucleus assay with V79 cells for detection of aneugenic effects

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https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Chapter 4 Preparation of Isolated Rat Liver Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Evaluation of the alkaline elution/rat hepatocyte assay as a predictor of carcinogenic/mutagenic potential.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Differences in responses of 4 adult rat-liver epithelial cell lines to a spectrum of chemical mutagens

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Cyproterone acetate generates DNA adducts in rat liver and in primary rat hepatocyte cultures.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

An improved method of mouse liver micronucleus analysis: an application to age-related genetic alteration and polyploidy study.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

A 7-hydroxymethyl sulfate ester as an active metabolite of 7,12-dimethylbenz[alpha]anthracene.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

Carcinogen-induced dna repair in primary rat liver cell cultures; a possible screen for chemical carcinogens

1 reference

https://api.crossref.org/works/10.1016%2FS0165-1218%2897%2900051-7

7 January 2021

10.1016/S0165-1218(97)00051-7

Identifiers

DOI

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4 October 2017

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