Proliferative lifespan checkpoints: cell-type specificity and influence on tumour biology (Q41583628)

4 October 2017

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title

Proliferative lifespan checkpoints: cell-type specificity and influence on tumour biology (English)

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4 October 2017

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Wynford-Thomas D

1

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4 October 2017

1 April 1997

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European Journal of Cancer

4 October 2017

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4 October 2017

33

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4 October 2017

5

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4 October 2017

716-726

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THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

4 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

The segregation of DNA in epithelial stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Replicative senescence: the human fibroblast comes of age.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Small peptides activate the latent sequence-specific DNA binding function of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Increased p53 protein associated with aging in human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Investigation of the role of G1/S cell cycle mediators in cellular senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Evidence for a p53‐independent pathway for upregulation of SDI1/CIP1/WAF1/P21 RNA in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Dependence of cyclin E-CDK2 kinase activity on cell anchorage.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

p53-dependent apoptosis suppresses tumor growth and progression in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

The retinoblastoma protein and cell cycle control

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Cell-cycle regulators and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Does telomere shortening drive selection for p53 mutation in human cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Sandwiching of a gene within 12 kb of a functional telomere and alpha satellite does not result in silencing

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

SV40-transformed human cells in crisis exhibit changes that occur in normal cellular senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Telomere elongation in immortal human cells without detectable telomerase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Finite life span of hybrids formed by fusion of different simian virus 40-immortalized human cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Studies demonstrating the complexity of regulation and action of the growth inhibitory gene SDI1

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Regulation of telomerase activity in immortal cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Immortalization of human mammary epithelial cells by SV40 large T-antigen involves a two step mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Spontaneous de-differentiation correlates with extended lifespan in transformed thyroid epithelial cells: an epigenetic mechanism of tumour progression?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Direct growth stimulation of normal human epithelial cells by mutant p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

A variant epithelial sub-population in normal thyroid with high proliferative capacity in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Elevated wild-type p53 protein levels in human epithelial cell lines immortalized by the human papillomavirus type 16 E7 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

Molecular genetics of thyroid cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2897%2900064-6

7 January 2021

10.1016/S0959-8049(97)00064-6

Identifiers

DOI

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4 October 2017

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PubMed ID

9282110