Matrix metalloproteinases. Novel targets for directed cancer therapy (Q41597461)

4 October 2017

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title

Matrix metalloproteinases. Novel targets for directed cancer therapy (English)

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4 October 2017

Yu AE

1

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4 October 2017

Hewitt RE

series ordinal

2

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4 October 2017

Connor EW

series ordinal

3

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4 October 2017

Stetler-Stevenson WG

series ordinal

4

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4 October 2017

publication date

1 September 1997

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4 October 2017

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4 October 2017

volume

11

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4 October 2017

issue

3

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4 October 2017

page(s)

229-244

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Regulation of matrix metalloproteinases during extracellular matrix turnover.

4 October 2017

cites work

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12 December 2020

Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells.

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12 December 2020

Structure of human neutrophil collagenase reveals large S1′ specificity pocket

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12 December 2020

Growth factors in the regulation of pericellular proteolysis: a review

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12 December 2020

Tumor cell-derived collagenase-stimulatory factor increases expression of interstitial collagenase, stromelysin, and 72-kDa gelatinase

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12 December 2020

Gelatinase A expression and localization in human breast cancers. An in situ hybridization study and immunohistochemical detection using confocal microscopy

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12 December 2020

Inhibition of angiogenesis by tissue inhibitor of metalloproteinase

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12 December 2020

A synthetic peptide metalloproteinase inhibitor, but not TIMP, prevents the breakdown of proteoglycan within articular cartilage in vitro

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12 December 2020

Expression of metalloproteinase genes in human prostate cancer

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12 December 2020

Different mechanisms of extracellular matrix remodeling by fibroblasts in response to human mammary neoplastic cells

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12 December 2020

Induction of angiogenesis during the transition from hyperplasia to neoplasia

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12 December 2020

Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor

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12 December 2020

Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2.

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12 December 2020

Expression of activated gelatinase in human invasive breast carcinoma

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12 December 2020

Expression of 72 kilodalton type IV collagenase (gelatinase A) in benign and malignant ovarian tumors

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12 December 2020

Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment

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12 December 2020

Circulating levels of soluble CD23 reflect clinical and biological features of leukemic B-cell chronic lymphoproliferative disorders

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12 December 2020

Inhibition of collagenolytic activity and metastasis of tumor cells by a recombinant human tissue inhibitor of metalloproteinases

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12 December 2020

Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis

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12 December 2020

Therapeutic effect of the matrix metalloproteinase inhibitor, batimastat, in a human colorectal cancer ascites model

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12 December 2020

Galectin-3 is a novel substrate for human matrix metalloproteinases-2 and -9.

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12 December 2020

Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family

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12 December 2020

Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas

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12 December 2020

The activation of human type IV collagenase proenzyme. Sequence identification of the major conversion product following organomercurial activation

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12 December 2020

Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma

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12 December 2020

Messenger RNA for two type IV collagenases is located in stromal cells in human colon cancer.

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12 December 2020

Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion.

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12 December 2020

Expression of metalloproteinases and their inhibitors in primary pulmonary carcinomas

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12 December 2020

Evaluation of hepatocellular carcinoma aggressiveness by a panel of extracellular matrix antigens

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12 December 2020

Inhibition of interleukin 1 beta induced rat and human cartilage degradation in vitro by the metalloproteinase inhibitor U27391.

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12 December 2020

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

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12 December 2020

Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization

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12 December 2020

Correlation between collagenolytic activity and grade of histological differentiation in colorectal tumors

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12 December 2020

The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A.

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12 December 2020

Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.

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12 December 2020

Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples.

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12 December 2020

Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor

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12 December 2020

Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.

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12 December 2020

Tumor Cell Invasion Inhibited by TIMP-2

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12 December 2020

Crystal structures, spectroscopic features, and catalytic properties of cobalt(II), copper(II), nickel(II), and mercury(II) derivatives of the zinc endopeptidase astacin. A correlation of structure and proteolytic activity

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12 December 2020

Interstitial collagenase gene expression in colonic neoplasia

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12 December 2020

Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models

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12 December 2020

Interstitial collagenase gene expression in oral squamous cell carcinoma

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12 December 2020

Inhibition of human type IV collagenase by a highly conserved peptide sequence derived from its prosegment

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12 December 2020

Expression of membrane-type matrix metalloproteinase in human gastric carcinomas

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12 December 2020

Effect of natural protease inhibitors and a chemoattractant on tumor cell invasion in vitro.

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12 December 2020

A matrix metalloproteinase expressed on the surface of invasive tumour cells

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12 December 2020

Inhibition of tumor invasion of smooth muscle cell layers by recombinant human metalloproteinase inhibitor.

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12 December 2020

P53 gene alterations in human tumors: perspectives for cancer control.

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12 December 2020

Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor

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12 December 2020

Extracellular matrices expression in invasion area of adenoid cystic carcinoma of salivary glands

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12 December 2020

X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily

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12 December 2020

Higher-order complex formation between the 72-kilodalton type IV collagenase and tissue inhibitor of metalloproteinases-2

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12 December 2020

Progelatinase A activation during tumor cell invasion.

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12 December 2020

The role of the C-terminal domain in collagenase and stromelysin specificity

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12 December 2020

Extracellular matrix and beta 1 integrin expression in nodal and extranodal T-cell lymphomas

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12 December 2020

Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, sporadic colorectal neoplasia, pulmonary carcinomas and malignant non-Hodgkin's lymphomas in humans

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12 December 2020

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

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12 December 2020

Pharmacological inhibition of gelatinase B induction and tumor cell invasion

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12 December 2020

Thiol-based inhibitors of mammalian collagenase. Substituted amide and peptide derivatives of the leucine analogue, 2-[(R,S)-mercaptomethyl]-4-methylpentanoic acid

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12 December 2020

The role of matrix metalloproteases and their inhibitors in tumour invasion, metastasis and angiogenesis.

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12 December 2020

Expression and in-situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer.

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12 December 2020

Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1

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12 December 2020

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family

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12 December 2020

Dual over-expression pattern of membrane-type metalloproteinase-1 in cancer and stromal cells in human gastrointestinal carcinoma revealed by in situ hybridization and immunoelectron microscopy

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12 December 2020

Potent collagenase inhibitors prevent interleukin-1-induced cartilage degradation in vitro

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12 December 2020

Detection of mRNAs encoding collagenase I and stromelysin 2 in carcinomas of the head and neck by in situ hybridization

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12 December 2020

Clinical trials of a low molecular weight matrix metalloproteinase inhibitor in cancer

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12 December 2020

The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily

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12 December 2020

Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4

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12 December 2020

Solution structure of the catalytic domain of human stromelysin complexed with a hydrophobic inhibitor.

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12 December 2020

Competitive inhibition of human skin collagenase by N-benzyloxycarbonyl-L-prolyl-L-alanyl-3-amino-2-oxopropyl-L-leucyl-L- alanylglycine ethyl ester

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12 December 2020

Over-expression of tissue inhibitor of matrix metalloproteinases (TIMP1 and TIMP2) suppresses extravasation of pulmonary metastasis of a rat bladder carcinoma

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12 December 2020

Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia

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12 December 2020

Collagenase inhibitors: their design and potential therapeutic use.

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12 December 2020

Breast-cancer-associated stromelysin-3 gene is expressed in basal cell carcinoma and during cutaneous wound healing

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12 December 2020

Cell surface binding of TIMP-2 and pro-MMP-2/TIMP-2 complex

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12 December 2020

Tumor cell interactions with the extracellular matrix during invasion and metastasis

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12 December 2020

Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage

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12 December 2020

Laminin receptors, collagenase IV and prognosis in node-negative breast cancers

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12 December 2020

Clinical implications of serum levels of soluble CD23 and tumor necrosis factor alpha in low-grade non-Hodgkin's lymphoma

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12 December 2020

Inhibition of AIDS-Kaposi's sarcoma cell induced endothelial cell invasion by TIMP-2 and a synthetic peptide from the metalloproteinase propeptide: implications for an anti-angiogenic therapy

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12 December 2020

A helping hand for collagenases: the haemopexin-like domain

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12 December 2020

Assessment of the role of the fibronectin-like domain of gelatinase A by analysis of a deletion mutant.

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12 December 2020

Expression and localization of the matrix metalloproteinase pump-1 (MMP-7) in human gastric and colon carcinomas

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12 December 2020

Stromelysin-3 gene expression in human cancer: an overview

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12 December 2020

Using inhibitors of metalloproteinases to treat arthritis. Easier said than done?

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12 December 2020

The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity

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12 December 2020

92 kDa type IV collagenase (MMP-9) is expressed in neutrophils and macrophages but not in malignant epithelial cells in human colon cancer

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12 December 2020

The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases

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12 December 2020

Expression of immunoreactive matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human normal livers and primary liver tumors

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12 December 2020

High levels of tissue inhibitor of metalloproteinase-2 (TIMP-2) expression are associated with poor outcome in invasive bladder cancer.

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12 December 2020

Collagenase stimulation in cocultures of human fibroblasts and human tumor cells

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12 December 2020

Processing of a precursor of 72-kilodalton type IV collagenase/gelatinase A by a recombinant membrane-type 1 matrix metalloproteinase.

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12 December 2020

Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues

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12 December 2020

Combination therapy including a gelatinase inhibitor and cytotoxic agent reduces local invasion and metastasis of murine Lewis lung carcinoma

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12 December 2020

Crystal structure of the haemopexin-like C-terminal domain of gelatinase A

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12 December 2020

Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro.

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12 December 2020

Membrane type-matrix metalloproteinase and tumor invasion

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12 December 2020

Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94)

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12 December 2020

Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer

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12 December 2020

Tissue inhibitor of metalloproteinase 1 is a negative regulator of the metastatic ability of a human gastric cancer cell line, KKLS, in the chick embryo.

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12 December 2020

Coordinate enhancement of gelatinase A mRNA and activity levels in human fibroblasts in response to breast-adenocarcinoma cells.

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12 December 2020

Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells

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12 December 2020

Gelatinase A (MMP-2) and its mRNA detected in both neoplastic and stromal cells of tumors with different invasive and metastatic properties

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12 December 2020

Human 92kDa type IV collagenase: Functional analysis of fibronectin and carboxyl-end domains

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12 December 2020

Inhibition of collagenase by aranciamycin and aranciamycin derivatives

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12 December 2020

Metalloproteinase-dependent neurite outgrowth within a synthetic extracellular matrix is induced by nerve growth factor

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12 December 2020

Activity of some lysosomal hydrolases in the homogenates of transplantable melanotic and amelanotic melanoma in golden hamster (Mesocricetus auratus, Waterhouse)

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12 December 2020

Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy

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12 December 2020

In vivo model of cartilage degradation--effects of a matrix metalloproteinase inhibitor

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12 December 2020

The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family

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12 December 2020

Quantitative zymography: detection of picogram quantities of gelatinases

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12 December 2020

Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor

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12 December 2020

Inhibition of matrix metalloproteinases by peptidyl hydroxamic acids

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12 December 2020

Activity of type IV collagenases in benign and malignant breast disease

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12 December 2020

The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function

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12 December 2020

Increased expression of the 72-kd type IV collagenase in prostatic adenocarcinoma. Demonstration by immunohistochemistry and in situ hybridization

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12 December 2020

A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity

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12 December 2020

Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas

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12 December 2020

Tumor invasion and metastasis: an imbalance of positive and negative regulation.

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12 December 2020

Gelatinase A expression in human malignant gliomas.

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12 December 2020

Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas

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12 December 2020

Cancer invasion and metastasis: positive and negative regulatory elements

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12 December 2020

Localization of the 92 kd gelatinase mRNA in squamous cell and adenocarcinomas of the lung using in situ hybridization.

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12 December 2020

Expression of bcl-2 oncoprotein and p53 protein accumulation in bone marrow metastases of androgen independent prostate cancer

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12 December 2020

Inhibition of Angiogenesis and Murine Hemangioma Growth by Batimastat, a Synthetic Inhibitor of Matrix Metalloproteinases

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12 December 2020

Studies on collagenase inhibitors. II. Inhibitory effects of anthraquinones on bacterial collagenase

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12 December 2020

Gene expression of interstitial collagenase (matrix metalloproteinase 1) in gastrointestinal tract cancers

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12 December 2020

Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.

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12 December 2020

Purification of rabbit bone inhibitor of collagenase

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12 December 2020

Cell surface-mediated activation of progelatinase A: demonstration of the involvement of the C-terminal domain of progelatinase A in cell surface binding and activation of progelatinase A by primary fibroblasts

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12 December 2020

Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia

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12 December 2020

10.2165/00002512-199711030-00006

Identifiers

DOI

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Dimensions Publication ID

4 October 2017

1013611449

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