The P-glycoprotein multidrug transporter (Q41597554)

4 October 2017

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title

The P-glycoprotein multidrug transporter (English)

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4 October 2017

Fardel O

1

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PubMed ID

9304397

4 October 2017

Lecureur V

series ordinal

2

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PubMed ID

9304397

4 October 2017

Guillouzo A

series ordinal

3

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4 October 2017

1 December 1996

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4 October 2017

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4 October 2017

27

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4 October 2017

8

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4 October 2017

1283-1291

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Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus

4 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Expression of a drug resistance gene in human neuroblastoma cell lines: modulation by retinoic acid-induced differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Differential modulation of P-glycoprotein transport by protein kinase inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Correlation of MDR1 gene expression with chemotherapy in neuroblastoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Localization of the human multiple drug resistance gene, MDR1, to 7q21.1

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Expression of P-glycoprotein and glutathione-S-transferase in recurrent lymphomas: the possible role of Epstein-Barr virus, immunophenotypes, and other predisposing factors

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Structure and expression of the human MDR (P-glycoprotein) gene family

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Doxorubicin-loaded nanospheres bypass tumor cell multidrug resistance

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https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Low incidence of MDR1 expression in acute promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Detection of P glycoprotein activity on normal and leukemic CD34+ cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Modulation of P-glycoprotein-mediated multidrug resistance by monoclonal antibodies, immunotoxins or antisense oligodeoxynucleotides in kidney carcinoma and normal kidney cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

P-glycoprotein expression in human, mouse, hamster and rat hepatocytes in primary culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Regulation by dexamethasone of P-glycoprotein expression in cultured rat hepatocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Constitutive expression of functional P-glycoprotein in rat hepatoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Rifampicin enhances anti-cancer drug accumulation and activity in multidrug-resistant cells

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Regulation of 2-acetylaminofluorene-and 3-methylcholanthrene-mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Regulation of P-glycoprotein gene expression in hepatocyte cultures and liver cell lines by a trans-acting transcriptional repressor

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Expression of a multidrug resistance gene in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Isolation and expression of a complementary DNA that confers multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Multidrug resistance in B-cell chronic lymphocytic leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Rational design and pre-clinical pharmacology of drugs for reversing multidrug resistance

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https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Is the multidrug transporter a flippase?

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

The effect of MDR-1 gene expression on outcome in acute myeloblastic leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Overexpression of the MDR1 gene and P-glycoprotein in human hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Structural and functional analyses of the promoter of the murine multidrug resistance gene mdr3/mdr1a reveal a negative element containing the AP-1 binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Restoration of taxol sensitivity of multidrug-resistant cells by the cyclosporine SDZ PSC 833 and the cyclopeptolide SDZ 280-446

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Selective drug transport and P-glycoprotein activity in an in vitro blood-brain barrier model

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Ribozyme-mediated cleavage of the MDR-1 transcript restores chemosensitivity in previously resistant cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Heat-shock responsive elements in the induction of the multidrug resistance gene (MDR1).

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Constitutive expression of multidrug resistance in human colorectal tumours and cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Expression and function of multidrug resistance P-glycoprotein in a cultured natural killer cell-rich population revealed by MRK16 monoclonal antibody and AHC-52

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

The direct activation of human multidrug resistance gene (MDR1) by anticancer agents

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Expression of the multidrug transporter, P-glycoprotein, in chronic myelogenous leukaemia cells in blast crisis.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

MDR1 gene expression in lung cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

The antiprogestatin drug RU 486 potentiates doxorubicin cytotoxicity in multidrug resistant cells through inhibition of P-glycoprotein function.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Expression of the multidrug resistance gene product (P-glycoprotein) in myelodysplasia is associated with a stem cell phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Phosphorylation of the multidrug resistance associated glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Electrophoretic analysis of 248 clinical breast cancer specimens for P-glycoprotein overexpression or gene amplification.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Use of fluorescent dyes as molecular probes for the study of multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Multidrug resistance (mdr) genes in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Systemic toxic effects associated with high-dose verapamil infusion and chemotherapy administration

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

GST-pi and P-170 co-expression in multiple myeloma

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

MDR1 gene expression and treatment outcome in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Cell-specific activity of cis-acting regulatory elements in the promoter of the mouse multidrug resistance gene mdr1.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Multiple drug resistance gene expression in human renal cell cancer is associated with the histologic subtype

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Suppression of multi-drug resistance gene expression in the mouse liver by 1,4-bis[2,(3,5-dichloropyridyloxy)]benzene.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Monoclonal antibody JSB-1 detects a highly conserved epitope on the P-glycoprotein associated with multi-drug-resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

P-glycoprotein expression in treated and untreated human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Metabolic activation of 2-acetylaminofluorene is required for induction of multidrug resistance gene expression in rat liver cells

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Reconstitution of drug transport by purified P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Modulation of multidrug resistance: at the threshold

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Characterization of the basal and carcinogen regulatory elements of the rat mdr1b promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Modulation of doxorubicin resistance in multidrug-resistant cells by liposomes

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Cortisol is transported by the multidrug resistance gene product P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Resistance to cytostatic drugs at the cellular level

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Low external pH and osmotic shock increase the expression of human MDR protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Multidrug resistance in lymphomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0306-3623%2896%2900081-X

7 January 2021

10.1016/S0306-3623(96)00081-X

Identifiers

DOI

1 reference

4 October 2017

1 reference

PubMed ID

9304397