Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs. (Q41601675)

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18 March 2020

title

Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs (English)

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18 March 2020

7

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18 March 2020

author name string

Vikas Tyagi

1

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18 March 2020

Hanan Alwaseem

2

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18 March 2020

Kristen M O'Dwyer

3

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18 March 2020

Jessica Ponder

4

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18 March 2020

Qi Ying Li

5

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18 March 2020

Craig T Jordan

6

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18 March 2020

language of work or name

English

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publication date

16 June 2016

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Bioorganic & Medicinal Chemistry

18 March 2020

published in

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18 March 2020

volume

24

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18 March 2020

issue

17

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18 March 2020

page(s)

3876-3886

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Dimers of Melampomagnolide B Exhibit Potent Anticancer Activity against Hematological and Solid Tumor Cells

18 March 2020

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Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide

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A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside

6 June 2018

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6 June 2018

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Perspectives on sesquiterpene lactones in inflammation and cancer

6 June 2018

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What made sesquiterpene lactones reach cancer clinical trials?

6 June 2018

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Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1).

6 June 2018

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Modulation of DNA methylation by a sesquiterpene lactone parthenolide

6 June 2018

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6 June 2018

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Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)

6 June 2018

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Modeling the initiation and progression of human acute leukemia in mice

6 June 2018

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Synthesis of 13-amino costunolide derivatives as anticancer agents

6 June 2018

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6 June 2018

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The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells

6 June 2018

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Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase.

6 June 2018

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6 June 2018

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6 June 2018

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6 June 2018

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6 June 2018

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Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions.

19 August 2018

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19 August 2018

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Biotransformation of beta-ionone by engineered cytochrome P450 BM-3.

19 August 2018

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Biotransformation of the sesquiterpene (+)-valencene by cytochrome P450cam and P450BM-3.

19 August 2018

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Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity

19 August 2018

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19 August 2018

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Further improvement of phosphite dehydrogenase thermostability by saturation mutagenesis

4 November 2018

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Identification and characterization of two functional domains in cytochrome P-450BM-3, a catalytically self-sufficient monooxygenase induced by barbiturates in Bacillus megaterium

4 November 2018

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12 December 2020

Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta

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12 December 2020

Melampomagnolide B: a new antileukemic sesquiterpene

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12 December 2020

P450 fingerprinting method for rapid discovery of terpene hydroxylating P450 catalysts with diversified regioselectivity

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12 December 2020

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27396927%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

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18 March 2020

PubMed publication ID

27396927

1 reference