Primary hepatocyte cultures as an in vitro experimental model for the evaluation of pharmacokinetic drug-drug interactions (Q41619430)

5 October 2017

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title

Primary hepatocyte cultures as an in vitro experimental model for the evaluation of pharmacokinetic drug-drug interactions (English)

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5 October 2017

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Li AP

1

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5 October 2017

publication date

1 January 1997

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5 October 2017

published in

Advances in Pharmacology

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5 October 2017

volume

43

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5 October 2017

page(s)

103-130

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Inducibility of ethoxyresorufin deethylase and UDP-glucuronosyltransferase activities in two human hepatocarcinoma cell lines KYN-2 and Mz-Hep-1.

5 October 2017

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Omeprazole, an inducer of human CYP1A1 and 1A2, is not a ligand for the Ah receptor

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Evaluation of cyclosporin-phenytoin interaction with observations on cyclosporin metabolites

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The increase in urinary excretion of 6 beta-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction

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Culture of human hepatocytes from small surgical liver biopsies. Biochemical characterization and comparison with in vivo

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Clinically significant drug interactions with antituberculosis agents

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Mixed function oxidase and UDP-glucuronyltransferase activities in the human Hep G2 hepatoma cell line

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7 January 2021

Metabolism of 17 alpha-ethynylestradiol in humans

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Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

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7 January 2021

Itraconazole affects single-dose terfenadine pharmacokinetics and cardiac repolarization pharmacodynamics

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7 January 2021

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Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

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Evaluation of the uptake of pravastatin by perfused rat liver and primary cultured rat hepatocytes

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7 January 2021

Evaluation of drug interactions in intact hepatocytes: Inhibitors of terfenadine metabolism

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7 January 2021

Sulfation and glucuronidation of acetaminophen by cultured hepatocytes reproducing in vivo sex-differences in conjugation on Matrigel and type 1 collagen

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Comparative effects of omeprazole on xenobiotic metabolizing enzymes in the rat and human

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Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes

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7 January 2021

Use of Aroclor 1254-induced rat liver homogenate in the assaying of promutagens in Chinese hamster ovary cells

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7 January 2021

Preclinical evaluation of drug-drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction.

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7 January 2021

Substrates of human hepatic cytochrome P450 3A4.

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7 January 2021

Promutagen activation by freshly isolated and cryopreserved rat hepatocytes

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7 January 2021

Optimization of cryopreservation procedures for rat and human hepatocytes

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7 January 2021

Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes

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7 January 2021

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7 January 2021

Expression of cytochrome P-450 enzymes in cultured human hepatocytes

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7 January 2021

Metabolism of the new immunosuppressor cyclosporin G by human liver cytochromes P450

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7 January 2021

Torsades de pointes after terfenadine-itraconazole interaction

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7 January 2021

HepG2 cells: an in vitro model for P450-dependent metabolism of acetaminophen

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7 January 2021

Induction of CYP1A and glutathione S-transferase activities by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatocyte cultures.

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7 January 2021

Induction and autoinduction properties of rifamycin derivatives: a review of animal and human studies

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7 January 2021

Induction of cytochrome P450 3A by metyrapone in human hepatocyte culture

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7 January 2021

Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics

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7 January 2021

Multiple drug interactions with cyclosporine in a heart transplant patient

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7 January 2021

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Identifiers

DOI

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