Clinical and molecular aspects of motoneurone diseases: animal models, neurotrophic factors and Bcl-2 oncoprotein (Q41622539)

5 October 2017

1 reference

title

Clinical and molecular aspects of motoneurone diseases: animal models, neurotrophic factors and Bcl-2 oncoprotein (English)

1 reference

5 October 2017

Sagot Y

1

1 reference

5 October 2017

Vejsada R

series ordinal

2

1 reference

5 October 2017

Kato AC

series ordinal

3

1 reference

5 October 2017

publication date

1 September 1997

1 reference

Trends in Pharmacological Sciences

5 October 2017

published in

1 reference

5 October 2017

volume

18

1 reference

5 October 2017

issue

9

1 reference

5 October 2017

page(s)

330-337

1 reference

The mouse mutation progressive motor neuronopathy (pmn) maps to chromosome 13

5 October 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Superoxide dismutase in familial amyotrophic lateral sclerosis: models for gain of function

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Identification and characterization of a spinal muscular atrophy-determining gene

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Early detection of mouse wobbler mutation: a model of pathological motoneurone death

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

An hereditary motor neurone disease with progressive denervation of muscle in the mouse: the mutant 'wobbler'.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Spinal motor neurones in murine muscular dystrophy and spinal muscular atrophy: A quantitative histological study

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Motoneuron loss in the abducens nucleus of wobbler mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Impaired slow axonal transport in wobbler mouse motor neuron disease

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Beneficial effects of insulin-like growth factor-I on wobbler mouse motoneuron disease

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

The motoneuron degeneration in the wobbler mouse is independent of the overexpression of a Bcl2 transgene in neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Bcl-2 sensitivity differentiates two pathways for motoneuronal death in the wobbler mutant mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

A therapeutic trial of gangliosides and thymosin in the Wobbler mouse model of motor neuron disease

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

A new mouse mutant with progressive motor neuronopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Polymer Encapsulated Cell Lines Genetically Engineered to Release Ciliary Neurotrophic Factor Can Slow Down Progressive Motor Neuronopathy in the Mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Nerve and muscle development in paralysé mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

The paralysé mouse mutant: a new animal model of anterior horn motor neuron degeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Impairment of fast axonal transport in the proximal axons of anterior horn neurons in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Neuronal intermediate filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Neurotrophic factors: from molecule to man.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Neurotrophic factors for experimental treatment of motoneuron disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Neurotrophic survival molecules for motoneurons: an embarrassment of riches

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Muscle-derived neurotrophin-4 as an activity-dependent trophic signal for adult motor neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Neurotropic factors, retrograde axonal transport and cell signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Ciliary neurotrophic factor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

The GDNF receptor: recent progress and unanswered questions

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Transforming growth factor alpha (TGF alpha) expression in degenerating motoneurons of the murine mutant wobbler: a neuronal signal for astrogliosis?

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Inhibition of ICE slows ALS in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

The Trk family of neurotrophin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

The neurotrophins and CNTF: two families of collaborative neurotrophic factors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Intracellular signaling pathways activated by neurotrophic factors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

STATs: signal transducers and activators of transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Sensory but not motor neuron deficits in mice lacking NT4 and BDNF

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Reduction in the number of spinal motor neurons in neurotrophin-3-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Disruption of the CNTF gene results in motor neuron degeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIF

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Renal and neuronal abnormalities in mice lacking GDNF

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Essential function of LIF receptor in motor neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Neural Development: A ‘LIM code’ for motor neurons?

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Expression and regulation of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in distinct avian motoneuron subsets

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Brain-derived proteins that rescue spinal motoneurons from cell death in the chick embryo: comparisons with target-derived and recombinant factors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Differential vulnerability of two subsets of spinal motor neurons in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Differential abundance of glutamate transporter subtypes in amyotrophic lateral sclerosis (ALS)-vulnerable versus ALS-resistant brain stem motor cell groups

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Brainstem motoneuron pools that are selectively resistant in amyotrophic lateral sclerosis are preferentially enriched in parvalbumin: Evidence from monkey brainstem for a calcium-mediated mechanism in sporadic ALS

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Physiology of the neurotrophins

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Cardiotrophin-1, a cytokine present in embryonic muscle, supports long-term survival of spinal motoneurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Bcl-2 gene family in the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Very Slow Retrograde and Wallerian Degeneration in the CNS of C57BL/Ola Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Glial cells are increased proportionally in transgenic optic nerves with increased numbers of axons.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Bcl-2 promotes regeneration of severed axons in mammalian CNS

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

BDNF-mediated rescue of axotomized motor neurones decreases with increasing dose

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Differential Regulation of p21ras Activation in Neurons by Nerve Growth Factor and Brain-derived Neurotrophic Factor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Characteristics of BDNF-induced weight loss.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Induction of cell death by endogenous nerve growth factor through its p75 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Potentiated necrosis of cultured cortical neurons by neurotrophins

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

ALS claims another victim

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2897%2901094-8

7 January 2021

10.1016/S0165-6147(97)01094-8

Identifiers

DOI

1 reference

5 October 2017

1 reference