Regulation and function of the JNK subgroup of MAP kinases (Q41659032)

6 October 2017

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title

Regulation and function of the JNK subgroup of MAP kinases (English)

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6 October 2017

A Minden

1

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6 October 2017

M Karin

series ordinal

2

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6 October 2017

publication date

1 October 1997

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Biochimica et Biophysica Acta

6 October 2017

published in

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6 October 2017

volume

1333

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6 October 2017

issue

2

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6 October 2017

page(s)

F85-104

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MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

6 October 2017

cites work

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Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

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Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

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Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

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7 January 2021

Raf-1 activates MAP kinase-kinase

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Transformation of mammalian cells by constitutively active MAP kinase kinase

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Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro

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7 January 2021

The mitogen-activated protein kinase activator

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7 January 2021

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

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7 January 2021

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

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7 January 2021

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

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7 January 2021

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

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7 January 2021

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase

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7 January 2021

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases

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JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

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Signal transduction by tumor necrosis factor mediated by JNK protein kinases

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7 January 2021

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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7 January 2021

Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway

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7 January 2021

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

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7 January 2021

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

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7 January 2021

Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

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7 January 2021

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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7 January 2021

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

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7 January 2021

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

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7 January 2021

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

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7 January 2021

Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain

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7 January 2021

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

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7 January 2021

Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase

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7 January 2021

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

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Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

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Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases

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An osmosensing signal transduction pathway in mammalian cells

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

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Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family

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Identification and Molecular Cloning of a p21cdc42/rac1-activated Serine/Threonine Kinase That Is Rapidly Activated by Thrombin in Platelets

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Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

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Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase

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7 January 2021

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

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7 January 2021

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7 January 2021

GTPase-deficient G alpha 16 and G alpha q induce PC12 cell differentiation and persistent activation of cJun NH2-terminal kinases

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7 January 2021

Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13

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7 January 2021

Selective interaction of JNK protein kinase isoforms with transcription factors

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7 January 2021

Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association

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7 January 2021

UV irradiation and heat shock mediate JNK activation via alternate pathways.

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7 January 2021

Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes

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7 January 2021

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

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7 January 2021

Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors

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7 January 2021

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal.

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7 January 2021

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

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Three distinct signalling responses by murine fibroblasts to genotoxic stress

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7 January 2021

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

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7 January 2021

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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7 January 2021

Protein kinase cascades activated by stress and inflammatory cytokines

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7 January 2021

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

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7 January 2021

Characterization of the structure and function of a novel MAP kinase kinase (MKK6)

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7 January 2021

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

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7 January 2021

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun

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7 January 2021

A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture

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7 January 2021

c-Jun is essential for normal mouse development and hepatogenesis

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7 January 2021

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

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7 January 2021

The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

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7 January 2021

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

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7 January 2021

A new group of conserved coactivators that increase the specificity of AP-1 transcription factors

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7 January 2021

A gene activated by growth factors is related to the oncogene v-jun

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7 January 2021

jun-D: a third member of the jun gene family

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7 January 2021

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

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7 January 2021

Rapid and preferential activation of the c-jun gene during the mammalian UV response

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7 January 2021

Induction of proto-oncogene JUN/AP-1 by serum and TPA.

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7 January 2021

Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha

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7 January 2021

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

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7 January 2021

Phosphorylation of c-jun mediated by MAP kinases.

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7 January 2021

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73

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7 January 2021

Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases

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7 January 2021

Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity

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7 January 2021

c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions

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7 January 2021

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

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7 January 2021

Use of an oriented peptide library to determine the optimal substrates of protein kinases

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7 January 2021

Transcription factor ATF2 regulation by the JNK signal transduction pathway

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7 January 2021

ATF-2 contains a phosphorylation-dependent transcriptional activation domain

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7 January 2021

The serum response element

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7 January 2021

Ternary complex factors: growth factor regulated transcriptional activators

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7 January 2021

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7 January 2021

Functional analysis of a growth factor-responsive transcription factor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Integration of MAP kinase signal transduction pathways at the serum response element

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Different requirements for formation of Jun: Jun and Jun: Fos complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Regulatory role of MEF2D in serum induction of the c-jun promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Molecular mechanisms of developmental neuronal death

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Role of CSB/p38/RK stress response kinase in LPS and cytokine signaling mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Prostaglandin synthase 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

The DNA binding activity of C/EBP transcription factor is regulated in the G1 phase of the hepatocyte cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

An essential role for Rac in Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

A role for Rho in Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

A role for Rac in Tiam1-induced membrane ruffling and invasion

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Multiple Ras functions can contribute to mammalian cell transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

The gene lin-3 encodes an inductive signal for vulval development in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Ras pathways in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

The Ras signaling pathway in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Three paths to stress relief

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Mechanism of inhibition of Raf-1 by protein kinase A.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Acetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of Raf activity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Increasing cAMP attenuates activation of mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

PHAS-I as a link between mitogen-activated protein kinase and translation initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900018-8

7 January 2021

10.1016/S0304-419X(97)00018-8

Identifiers

DOI

1 reference

6 October 2017

1 reference