Immunobiology of interleukin-12. (Q41710832)

7 October 2017

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title

Immunobiology of interleukin-12. (English)

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7 October 2017

Trinchieri G

1

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7 October 2017

1 January 1998

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7 October 2017

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7 October 2017

17

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7 October 2017

1-2

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7 October 2017

269-278

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https://scigraph.springernature.com/pub.10.1007/bf02786451

7 October 2017

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cites work

Interleukin-12 treatment during immunization elicits a T helper cell type 1-like immune response in mice challenged with respiratory syncytial virus and improves vaccine immunogenicity

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02786451

Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production

21 January 2018

1 reference

12 December 2020

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts

1 reference

12 December 2020

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

1 reference

12 December 2020

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients

1 reference

12 December 2020

Infection with Leishmania major induces interleukin-12 production in vivo

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12 December 2020

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

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12 December 2020

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice

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12 December 2020

Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-1 beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cells

1 reference

12 December 2020

Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells

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12 December 2020

Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases

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12 December 2020

Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent

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12 December 2020

IL-12 synthesis by human Langerhans cells

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12 December 2020

In vitro maturation of human neonatal CD4 T lymphocytes. I. Induction of IL-4-producing cells after long-term culture in the presence of IL-4 plus either IL-2 or IL-12

1 reference

12 December 2020

IL-12 inhibits IL-4 synthesis in keyhole limpet hemocyanin-primed CD4+ T cells through an effect on antigen-presenting cells.

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12 December 2020

IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes.

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12 December 2020

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

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12 December 2020

Regulation of human cytolytic lymphocyte responses by interleukin-12

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12 December 2020

CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages

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12 December 2020

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

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12 December 2020

Nonviable bacterial antigens administered with IL-12 generate antigen-specific T cell responses and protective immunity against Listeria monocytogenes

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12 December 2020

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

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12 December 2020

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells

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12 December 2020

Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon

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12 December 2020

Expression of cytokine mRNA in murine splenic dendritic cells and better induction of T cell-derived cytokines by dendritic cells than by macrophages during in vitro costimulation assay using specific antigens

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12 December 2020

Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites

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12 December 2020

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones

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12 December 2020

Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells

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12 December 2020

Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor

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12 December 2020

Mechanism of suppression of cell-mediated immunity by measles virus

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12 December 2020

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

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12 December 2020

Induction of IL-12 and chemokines by hyaluronan requires adhesion-dependent priming of resident but not elicited macrophages.

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12 December 2020

IL-12 modulation of T helper responses to the filarial helminth, Brugia malayi.

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12 December 2020

Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells

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12 December 2020

CR3-dependent resistance to acute Toxoplasma gondii infection in mice.

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12 December 2020

Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction

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12 December 2020

Antitumor and antimetastatic activity of interleukin 12 against murine tumors

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12 December 2020

Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130

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12 December 2020

Role of interferon-gamma in interleukin 12-induced pathology in mice.

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12 December 2020

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

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12 December 2020

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist

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12 December 2020

Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T cell activity. Implications for the age-related decline in CTL

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12 December 2020

The role of IL-12 in the induction of organ-specific autoimmune diseases

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12 December 2020

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

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12 December 2020

Cloning and characterization of a mouse IL-12 receptor-beta component.

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12 December 2020

Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma

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12 December 2020

IL-12 protects bone marrow from and sensitizes intestinal tract to ionizing radiation

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12 December 2020

Interleukin-12 synergizes with interleukin-3 and steel factor to enhance recovery of murine hemopoietic stem cells in liquid culture

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12 December 2020

Interleukin-12 and its role in the generation of TH1 cells

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12 December 2020

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers

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12 December 2020

Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells.

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12 December 2020

Interleukin-12 production by human polymorphonuclear leukocytes

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12 December 2020

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells

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12 December 2020

Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2

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12 December 2020

Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.

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12 December 2020

B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions

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12 December 2020

Role of interferon-gamma in mediating the antitumor efficacy of interleukin-12

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12 December 2020

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

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12 December 2020

IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-gamma-receptor-deficient mice

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12 December 2020

Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

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12 December 2020

The adjuvant effect of interleukin-12 in a vaccine against Leishmania major.

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12 December 2020

B7-1 and interleukin 12 synergistically induce effective antitumor immunity

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12 December 2020

Inhibition of angiogenesis in vivo by interleukin 12.

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12 December 2020

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12 December 2020

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

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12 December 2020

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo

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12 December 2020

T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-gamma and is inhibited by transforming growth factor-beta

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12 December 2020

Dual stimulatory and inhibitory effect of NK cell stimulatory factor/IL-12 on human hematopoiesis

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12 December 2020

Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes

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12 December 2020

An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

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12 December 2020

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation

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12 December 2020

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells

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12 December 2020

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

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12 December 2020

Biological function and distribution of human interleukin-12 receptor beta chain

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12 December 2020

Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells

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12 December 2020

IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia.

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12 December 2020

Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation.

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12 December 2020

Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones.

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12 December 2020

Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice.

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12 December 2020

Acute induction and priming for cytokine production in lymphocytes

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12 December 2020

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells

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12 December 2020

Differential effects of interleukin-12 on the development of naive mouse CD4+ T cells.

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12 December 2020

Impaired interleukin 12 production in human immunodeficiency virus-infected patients

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12 December 2020

HIV infection suppresses type 1 lymphokine and IL-12 responses to Toxoplasma gondii but fails to inhibit the synthesis of other parasite-induced monokines

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12 December 2020

Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction

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12 December 2020

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

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12 December 2020

The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells

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12 December 2020

IL-12 receptor. II. Distribution and regulation of receptor expression

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12 December 2020

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells

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12 December 2020

IL-1 beta is required for IL-12 to induce production of IFN-gamma by NK cells. A role for IL-1 beta in the T cell-independent mechanism of resistance against intracellular pathogens.

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12 December 2020

Selective expression of an interleukin-12 receptor component by human T helper 1 cells

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12 December 2020

Identifiers

DOI

10.1007/BF02786451

1 reference

PubMed ID

9479588

Dimensions Publication ID

7 October 2017

0 references

1 reference

PubMed ID

9479588