p53--an acrobat in tumorigenesis (Q41715281)

7 October 2017

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title

p53--an acrobat in tumorigenesis (English)

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7 October 2017

Moll UM

1

1 reference

PubMed ID

9488246

7 October 2017

Schramm LM

series ordinal

2

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PubMed ID

9488246

7 October 2017

language of work or name

English

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publication date

1 January 1998

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Journal of Dental Research

7 October 2017

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7 October 2017

9

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7 October 2017

1

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7 October 2017

23-37

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p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

7 October 2017

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Both viral (adenovirus E1B) and cellular (hsp 70, p53) components interact with centrosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Radiation-induced cell cycle arrest compromised by p21 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Induction of the growth inhibitor IGF-binding protein 3 by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Bcl-2 blocks p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Thymocyte apoptosis induced by p53-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

The mutational spectrum of single base-pair substitutions causing human genetic disease: patterns and predictions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

A p53-dependent mouse spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Inhibition of DNA replication factor RPA by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Wild-type p53 can inhibit oncogene-mediated focus formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

The p53 proto-oncogene can act as a suppressor of transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

A DNA binding domain is contained in the C-terminus of wild type p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Abnormal centrosome amplification in the absence of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Clinical implications of the p53 tumor-suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Mediation of c-Myc-induced apoptosis by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Small peptides activate the latent sequence-specific DNA binding function of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Inhibition of replicon initiation in human cells following stabilization of topoisomerase-DNA cleavable complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

p53 mutations increase resistance to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Systemic gene therapy with p53 reduces growth and metastases of a malignant human breast cancer in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Who is susceptible to cancers of the breast, colon, and prostate?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Human TAFII31 protein is a transcriptional coactivator of the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

DNA damage, p53 and anticancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Essential role for p53-mediated transcription in E1A-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Gene-targeting and the p53 tumor-suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Wild-type p53 binds to the TATA-binding protein and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Interference with p53 protein inhibits hematopoietic and muscle differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Functional inactivation but not structural mutation of p53 causes liver cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Characterization of RAD9 of Saccharomyces cerevisiae and evidence that its function acts posttranslationally in cell cycle arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

p21 is a universal inhibitor of cyclin kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

Sunburn and p53 in the onset of skin cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F10454411980090010101

10.1177/10454411980090010101

21 January 2018

Identifiers

DOI

1 reference

7 October 2017

1 reference

PubMed ID

9488246